Hey Folks! You asked for it, and we delivered. We're back with a Q&A episode! If you have a question for a future episode, submit them here https://robbwolf.com/contact/submit-a-question-for-the-podcast/   Show notes: 1. (4:41) Ketosis and Carbohydrate timing Ryan says: Hi Robb. I don't know if this will reach you, but while listening to your podcast and reading your first book, a hundred questions pop into my head. This is one of them. I thought about asking my doctor, but I knew a blank stare and a sweaty forehead would be his answer. So here goes: Does frequency of carb intake play a role in disrupting ketosis? For example, if I am going to eat 150 grams in total of carbohydrates today, will eating all 150 grams of carbs at the same meal knock me out of ketosis for an EQUAL amount of time as eating 15 grams every hour for 10 hours?* My theory is eating 15 grams of carbs an hour for 10 hours will be just enough to keep a person out of ketosis for a longer period of time than eating all 150 grams in one meal while carb-fasting for the rest of the day. I could be wrong, but that's why I'm asking the master. Thank you in advance for any time you can dedicate to the this question. Have a great day. *Lets assume we are talking about starchy carbohydrates (rice, potatoes, etc.), not leafy green vegetables or other low glycemic vegetables. ------------ Links: Meal frequency and timing in health and disease-PNAS https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4250148/   2. (9:34) Genetics and Keto Charles says: Robb mentioned in the Paleo(f)x keto interview that he had some genetics (SNPs) that perhaps made Keto not a great diet for him, yet he gets around it somewhat with some supplementation including with Carnitine. I dabble in Keto and have made lots of progress with my health as a result. I plan to sign up for the Master Class too. I have done genetic testing already with 23 and me. I wonder if Robb could tell me the SNPs to look for to see what kind of genetic fit Keto is for me. I have a feeling I will find out in the Master Class, but would love to hear what Robb has to say or perhaps there is a link to an article or podcast that would do the trick. ------------ Found my fitness genetic interpretation: https://www.foundmyfitness.com/genetics FTO gene is called fat mass and obesity-associated protein because it is the gene that is the major genetic risk factor for obesity. This particular genotype, rs17817449(G;T), is associated with a 1.3-fold increased obesity risk. Saturated fat may have a negative effect on blood glucose and insulin levels and increases type 2 diabetes risk in individuals with this genotype. All sat’d fats the same?? NO. No one asks why this is: Sat’d fats increase endotoxemia to some degree: Dietary oil composition differentially modulates intestinal endotoxin transport and postprandial endotoxemia-Nutrition and metabolism https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-10-6 Sat’d fats also tend to increase Lipoproteins and cholesterol, at least in some people. Is that bad? Maybe, maybe not, #context: https://www.google.com/search?q=LPS+clearance+lipoproteins&oq=LPS+clearance+lipoproteins&aqs=chrome..69i57.6086j0j4&sourceid=chrome&ie=UTF-8 Multiple mechanisms: 1-LPS binding protein 2-Multiple hepatic cells and receptors, including LDL-receptor 3-Small, dense lipoproteins work better for this!! In total, this FTO mutation is overall beneficial in dealing with endotoxemia dn infection. Consistent with other SNP’s I have (celiac potential, mild iron accretion). Shows direct influence of adaptations to agriculture. DAIRY really increases this for me.   3. (16:51) Familial history of cancer and the Ketogenic diet for prevention Clint says: Hey Robb- When I look back into my family history, a boatload of people have had various forms of cancer. We've run the gamut of colon cancer, breast cancer, cervical cancer, etc... I've listened to quite a few podcasts with Dominic D'Agostino i