Hey Folks! We're back with another Q&A episode! If you have a question for a future episode, especially questions for Tyler and Luis of KetoGains on the next Q&A, submit them here https://robbwolf.com/contact/submit-a-question-for-the-podcast/   Show Notes: (2:49) 23 and Me Kristin says: Robb and Nicki! Loved the first q&a back! I wanted to ask an expansion on the FTO gene Polymorphism question. I my self also ran my 23andme data through FoundMYFitness as a Rhonda Patrick follower and I have the similar FTO well several FTO genes came up but also the PPAR alpha gene came up that I know is a big part of ketosis. My question is can I attempt and Keto diet and Ketosis with using mainly PUFA and MUFA and still achieve ketosis with this polymorphism or am I better off to not focus on achieving ketosis?Thank you for all that you put in the world I just received you Wired to Eat book and started reading it! Love it so far!Kristin NOTES: FTO: https://academic.oup.com/jn/article/142/5/824/4630756 Fat Mass and Obesity–Associated Gene Evolutionary Advantage-STRONG tendency toward obesity. Powerful adaptation in ancestral environment. Evolutionary advantage not specific to Thrifty gene hypothesis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4031802/pdf/yjbm_87_2_99.pdf Susceptibility to obesity (and inflammation) https://www.diva-portal.org/smash/get/diva2:406173/FULLTEXT01.pdf Drivers towards energy efficiency...back side of this is constrained Energy Hypothesis: https://journals.lww.com/acsm-essr/Fulltext/2015/07000/Constrained_Total_Energy_Expenditure_and_the.3.aspx Game theory and energy balance: http://journals.sagepub.com/doi/full/10.1177/1550147717720792 PPAR Alpha: https://onlinelibrary.wiley.com/doi/epdf/10.1111/j.1528-1167.2008.01840.x Peroxisome proliferator-activated receptor alpha is a drug/fatty acid-activated transcription factor involved in the starvation response, Other SNP’s like CPT-1   (16:45) Ketone IVs / Ketone Ringer Stijn says: Dear Robb, Dear Robb Wolf team,For years I've wondered about using ketone bodies in IVs at intensive care, in the same way that glucose solutions are used. I imagine there being less inflammation versus the glucose, and thus better recovery. Though the effect might be minimal in a non-keto-adapted person. Then I am skipping over the entire blue light issue from all the fluorescents at a hospital. I recently watched your talk at Paleo FX, "Ketogenic Diets for Traumatic Brain Injury Keeping the Baby with the Bathwater". In brief you mention ketone ringers in an acute setting, traumatic brain injury and research in Japan. Why not use ketone bodies at intensive care, or even other settings? Have you seen research on this? Here's how I thought about it: my dad was at the ICU after cardiac arrest, and I saw the glucose syringes. Then I thought about inflammation and ketones. And I remembered reading that heart muscle likes ketones. Maybe we can save more people with ketone IVs...Please share your thoughts. I'm also interested in the Japanese research on ketone ringers, if you can link that.Thank you very much.Be well, Stijn De Puydt   NOTES: Ketone ringer solution- https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/152165401753311780 MCT Keto diet: https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/152165401753311780 High glucose load negated benefits!!   (20:54) Monkfruit G says: Hi. Can you briefly give me the straight dope on Monkfruit? I heard it doesn't spike your blood glucose levels making it a good alternative to sugar. I'm also guessing it still triggers pleasure centers in your brain which can lead to craving sweets. My girl wanted to know how does Monkfruit Maple Syrup differ from 100% Pure Maple Syrup? Thank you for your time, g Notes: https://www.nature.com/articles/ijo2016225 Generally not a huge effect: https://www.nature.com/articles/ijo2016225   (24:07) Alternatives to the classic Norcal Marg Colin says: Hey Rob, I like that you are back to doing some Q&A's and