Fluoroquinolone-Associated Disability (FQAD) - Pathogenesis, Diagnostics, Therapy and Diagnostic Criteria: Side-effects of Fluoroquinolones
()
About this ebook
In this book, Stefan Pieper supports doctors and therapists in easily diagnosing FQAD and in better and more adequately dealing with FQAD patients.
Fluoroquinolones, as one of the most common and effective groups of antibiotics, are known to have a distinct spectrum of side effects. These adverse effects are rare in percentage terms, but frequent in absolute numbers due to the enormous quantities of prescriptions. Because they are usually quite severe and wide-ranging, they tend to run like a syndrome and have been classified by the FDA as a separate condition, the FQAD, because of their frequency, severity and risk of disability.
This book presents for the first time a comprehensive description and classification of the clinical picture and a proposal for a clinical diagnostic tool based on diagnostic criteria.
Related to Fluoroquinolone-Associated Disability (FQAD) - Pathogenesis, Diagnostics, Therapy and Diagnostic Criteria
Related ebooks
COVID-19 in Clinical Practice: Lessons Learned and Future Perspectives Rating: 0 out of 5 stars0 ratingsDrug Interactions in Infectious Diseases: Mechanisms and Models of Drug Interactions Rating: 0 out of 5 stars0 ratingsImmunological and Blood Products: Pharmaceutical Monographs Rating: 0 out of 5 stars0 ratingsPharmaceutical Toxicology in Practice: A Guide to Non-clinical Development Rating: 0 out of 5 stars0 ratingsInfection Control in Primary Dental Care Rating: 0 out of 5 stars0 ratingsSurviving Coronavirus Rating: 0 out of 5 stars0 ratingsThe dark sides of the false coronavirus pandemic: facts and data hidden from the public: Based on 700+ scientific publications Rating: 0 out of 5 stars0 ratingsGene Therapy: Prospective Technology assessment in its societal context Rating: 0 out of 5 stars0 ratingsThe Vaccine Handbook: A Practical Guide for Clinicians, Twelfth Edition Rating: 0 out of 5 stars0 ratingsPharmaceutical Biotechnology: Fundamentals and Applications Rating: 5 out of 5 stars5/5Neuro-oncology Rating: 0 out of 5 stars0 ratingsPsycho-Oncology for the Clinician: The Patient Behind the Disease Rating: 0 out of 5 stars0 ratingsClinical Use of Immunoglobulins Rating: 0 out of 5 stars0 ratingsRapid Virus Diagnosis: Application of Immunofluorescence Rating: 0 out of 5 stars0 ratingsVaccines and CMV Reactivation Rating: 0 out of 5 stars0 ratingsVaccines: Making the Right Choice for Your Child Rating: 5 out of 5 stars5/5Perspectives in Medical Virology, vol. 1 Rating: 0 out of 5 stars0 ratingsHuman Fertility Control: Theory and Practice Rating: 0 out of 5 stars0 ratingsSmall Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration Rating: 0 out of 5 stars0 ratingsClinically Relevant Mycoses: A Practical Approach Rating: 0 out of 5 stars0 ratingsBiofilm, Pilonidal Cysts and Sinuses Rating: 0 out of 5 stars0 ratingsTreatment–Refractory Schizophrenia: A Clinical Conundrum Rating: 0 out of 5 stars0 ratingsLast Help: Phage Therapy?: For 100 Years, a Successful Alternative to Conventional Antibiotic Treatments Rating: 0 out of 5 stars0 ratingsNuclear Medicine in Infectious Diseases Rating: 0 out of 5 stars0 ratingsThe COVID-19 Pandemic: A Global High-Tech Challenge at the Interface of Science, Politics, and Illusions Rating: 0 out of 5 stars0 ratingsGenomic Biomarkers for Pharmaceutical Development: Advancing Personalized Health Care Rating: 0 out of 5 stars0 ratings
Medical For You
The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally Rating: 4 out of 5 stars4/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Mediterranean Diet Meal Prep Cookbook: Easy And Healthy Recipes You Can Meal Prep For The Week Rating: 5 out of 5 stars5/5The Lost Book of Simple Herbal Remedies: Discover over 100 herbal Medicine for all kinds of Ailment Inspired By Barbara O'Neill Rating: 0 out of 5 stars0 ratingsMating in Captivity: Unlocking Erotic Intelligence Rating: 4 out of 5 stars4/5Holistic Herbal: A Safe and Practical Guide to Making and Using Herbal Remedies Rating: 4 out of 5 stars4/5The Hormone Reset Diet: Heal Your Metabolism to Lose Up to 15 Pounds in 21 Days Rating: 4 out of 5 stars4/5ATOMIC HABITS:: How to Disagree With Your Brain so You Can Break Bad Habits and End Negative Thinking Rating: 5 out of 5 stars5/5Adult ADHD: How to Succeed as a Hunter in a Farmer's World Rating: 4 out of 5 stars4/5The Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Rating: 5 out of 5 stars5/5The 40 Day Dopamine Fast Rating: 4 out of 5 stars4/5Tight Hip Twisted Core: The Key To Unresolved Pain Rating: 4 out of 5 stars4/5Herbal Healing for Women Rating: 4 out of 5 stars4/5What Happened to You?: Conversations on Trauma, Resilience, and Healing Rating: 4 out of 5 stars4/5The Amazing Liver and Gallbladder Flush Rating: 5 out of 5 stars5/5Woman: An Intimate Geography Rating: 4 out of 5 stars4/5The White Coat Investor: A Doctor's Guide to Personal Finance and Investing Rating: 4 out of 5 stars4/5Women With Attention Deficit Disorder: Embrace Your Differences and Transform Your Life Rating: 5 out of 5 stars5/5The Gene: An Intimate History Rating: 4 out of 5 stars4/5David D. Burns’ Feeling Good: The New Mood Therapy | Summary Rating: 4 out of 5 stars4/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5Summary of Dr. Gundry's Diet Evolution: Turn off the Genes That Are Killing You and Your Waistline Rating: 3 out of 5 stars3/5Working Stiff: Two Years, 262 Bodies, and the Making of a Medical Examiner Rating: 4 out of 5 stars4/5Lifting the Fog: A specific guide to inattentive ADHD in adults Rating: 4 out of 5 stars4/5
Reviews for Fluoroquinolone-Associated Disability (FQAD) - Pathogenesis, Diagnostics, Therapy and Diagnostic Criteria
0 ratings0 reviews
Book preview
Fluoroquinolone-Associated Disability (FQAD) - Pathogenesis, Diagnostics, Therapy and Diagnostic Criteria - Stefan Pieper
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021
S. PieperFluoroquinolone-Associated Disability (FQAD) - Pathogenesis, Diagnostics, Therapy and Diagnostic Criteria https://doi.org/10.1007/978-3-030-74173-0_1
1. Introduction to FQAD
Stefan Pieper¹
(1)
Konstanz, Baden-Württemberg, Germany
Stefan Pieper
Email: kontakt@praxisdrpieper.de
Keywords
FluoroquinolonesFQADDisseminationAntibiotics
Since the exponential increase of new antibiotics in the second half of last century through focused research apart from the positive, life-saving effects, the uncritical and improper use has also increased enormously. Recent studies show that only 12.8% of prescriptions are indicated [1].
This circumstance is particularly problematic in the case of the so-called reserve antibiotics above all the fluoroquinolones (hereinafter FQs, for brevity) which are highly efficient to multi-resistant germs.
The medical newspaper Deutsches Ärzteblatt writes in 2019: ‘This substance group is a good example of how antibiotics can be burned
by an unselected and often not indicated use. Increasing resistances in the range of 20-30 % make the use in hospital urinary tract infections a lottery game’ [2].
Canadian research shows that almost every second patient has been treated with an FQ at least once in his lifetime [3].
An unimaginably large amount.
This figure is all the more credible when you consider that ciprofloxacin became the most frequently prescribed antibiotic in the USA between 1997 and 2002, with 22 million visits [4].
FQs are the first fully synthetic antibiotic group ever. They were discovered accidentally in the 1960s through contamination during the production of the malaria drug chloroquine.
Their main representatives, ciprofloxacin, ofloxacin, norfloxacin, levofloxacin, gemifloxacin and moxifloxacin, were developed into the most effective but also the most toxic antibiotics of all, but their risks and adverse effects (AEs) were long downplayed in science and by the regulatory authorities.
For this reason, warnings were issued by the American regulatory authority FDA only after decades, and even much later by European and German authorities. It would go too far to explain the rocky road from petitions, hearings, threats of legal action, etc. to recognition of the problem and further to the hesitant action of the supervisory authorities.
Since 2016, FQs in the USA have only a very narrow range of indications, for example for the most severe bacterial infections such as anthrax and plague as well as pneumonia that cannot be treated in any other way [5].
Unfortunately, these reasonable restrictions as a reserve antibiotic were not followed so consistently at the European level.
In 2015, the FDA, in its Antimicrobial Drugs Advisory Committee, determined that of 14 antibiotics investigated, FQs have by far the highest risk of disability [6].
The FQ-AEs sometimes cause severe long-term damage and reach a previously unknown extent. Such serious, diverse, resistance to therapy and disabling are these side effects that the umbrella term of fluoroquinolone-associated disability, which is now also recognized by the FDA, has become established in Anglo-American studies.
Based on the cases reported to the FDA, Charles Bennett, Center for Medication Safety and Efficacy, University of South Carolina, calculated that between Nov. 1997 and Feb. 2011, the number of cases of FQ in the USA ranged from two million to over 21 million and between 29,000 and over 299,000 deaths [7].
By German standards, this amounts to about 40,000 to 400,000 affected persons and 150 to 1500 deaths per year. (These figures are surprisingly well in line with the very conservative calculations of the AOK Scientific Institute ‘Wido’ in 2019, using a completely different calculation approach [8].)
Extrapolated over the last 30 years, this leads to at least 1.2 million victims only in Germany, most of whom are still alive due to their age distribution (83% under 60 years). Added to this are thousands, if not tens of thousands, of deaths since the introduction of the FQ in the 1980s.
With an invalidity rate of 15% [9], this means at least 180,000 severely disabled persons due to FQAD exist in Germany, and 6000 cases are added annually.
This corresponds roughly to the frequency of multiple sclerosis. Direct and indirect costs of MS patients in Germany amount to about 40,000 € per patient and year, a total of 8 billion € [10].
FQAD patients, whose disease is usually not diagnosed, not named and if so, not recognized but ignored, have nothing to expect from our health care system today. The majority of the costs spent on them concern unnecessary diagnostics, where no groundbreaking findings are made and which even ensures that these patients are at best misdiagnosed as psychosomatic or psychiatric, but are often stigmatized as