Fast Facts: Perioperative Pain: Effective management has numerous benefits
By M. Brown and K. Peperzak
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About this ebook
M. Brown
Martyn Brown was formerly a Senior Microbiologist at Unilever Savoury Global Supply Chain and Technology Group, UK. Now a consultant, he is an internationally-known authority on the management of food safety.
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Fast Facts - M. Brown
Introduction
The importance of effective and safe pain management in the perioperative period has never been greater. The populations we serve as clinicians are rapidly changing, with increases in age, frailty and complexity of comorbidities. When these factors are considered in combination with socioeconomic issues, such as the ‘opioid crisis’ and budgetary constraint, it is clear that the challenges of providing a high-quality perioperative experience are extensive.
Attention has recently focused on the benefits of ensuring that pain in surgical patients is managed in an effective and compassionate fashion. From reduced postsurgical complications and minimization of hospital length of stay to improved patient satisfaction, these benefits are numerous and multidimensional. There have also been huge advances in the way in which we manage the perioperative pathway, both technical and organizational, as well as greater understanding of the underlying pathophysiology of pain states. Innovation in point-of-care imaging techniques, drug delivery, data science and patient engagement have all incrementally expanded the repertoire of the pain specialist.
Fast Facts: Perioperative Pain provides a succinct and accessible guide to the practice of perioperative pain management, covering the complete surgical journey from the preoperative assessment phase through to postoperative management. Consideration is given to our underlying understanding of the science of acute pain and how to assess it, as well as detailing the approaches –medical and nonmedical – to managing acute pain and the evidence available to support these interventions. In addition, the phenomenon of persistent postsurgical pain is addressed, with an outline of its features, risk factors and potential preventive measures.
We trust that our book will prove a valuable resource for all multidisciplinary team members who encounter surgical patients in pain during the course of their work.
The International Association for the Study of Pain (IASP) defines pain as ‘An unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage.’¹ Acute pain as it relates to postoperative care is pain that is temporally related to a specific procedure and expected to reduce during an appropriate period of healing.²,³ Social, cultural and personality factors may affect a patient’s perception and response to pain, but generally acute pain responds well to treatment with analgesics and treatments targeted to the precipitating cause.
Pain can be classified in many different ways based on time course, mechanism or etiology (Table 1.1). One common categorization is to differentiate between nociceptive and non-nociceptive pain.⁴
Nociceptive pain
Somatic nociceptive pain is typically described as sharp, dull or aching. It is often worsened with movement and improved with rest. It tends to be localized and associated with an underlying lesion.
Specific examples of nociceptive pain include postsurgical pain, musculoskeletal pain and arthritic pain. Visceral nociceptive pain is less well localized and may be described as deep cramping or squeezing pain. It may be associated with autonomic sensations such as nausea, vomiting and diaphoresis. Patterns of pain referral exist, such as shoulder pain produced by diaphragmatic irritation following laparoscopic surgery.⁵
Mechanistically, nociceptive pain begins with a noxious stimulus (mechanical, thermal or chemical) that activates peripheral nociceptors and sends impulses along myelinated Aδ and unmyelinated C fibers to the spinal cord. These fibers synapse in the dorsal horn of the spinal cord before ascending to the thalamus, hypothalamus, reticular system and cortex of the brain, where the emotional and stress responses to pain are regulated (Figure 1.1).
TABLE 1.1
Potential ways of classifying pain
Time course
Acute (<3 months)
Subacute (≥6 weeks,<3 months)
Chronic (≥3 months)
Episodic
Etiology
Cancerous
Ischemic
Postoperative
Injury
‘Cross-talk’ between sympathetic and sensory neurons
Type of injured tissue
Nociceptive
Neuropathic
Visceral
Somatic
Intensity
Mild
Moderate
Severe
Inferred mechanism
Tissue damage
Inflammation
Central sensitization of nociceptors
Nerve-damage-triggered neuroplasticity changes
Brain neuroplasticity changes
Loss of inhibition
Glia-derived neural sensitization
In general, postoperative pain includes at least some component of nociceptive pain, as the nervous system is perceiving tissue damage from the procedure itself or an injury prompting a procedure to be performed.⁶,⁷
Potentiation. Following tissue or nerve damage, central potentiation occurs when peripheral nociceptors become sensitized in response to the accumulation of various endogenous chemicals and inflammatory mediators, such as bradykinin, prostaglandins, histamine and interleukins (Figure 1.2). As pain persists, this sensitization and heightened afferent activity leads to chemical and anatomic reorganization in the spinal cord itself. In turn, this may lead to long-term central potentiation characterized by exaggerated responses to afferent impulses and an increased perception of pain (also known as nociplastic pain or pain that arises from altered nociception despite no actual or potential tissue damage).
Figure 1.1 Nociceptive pathways. Nociceptive pain does not rely solely on passive transduction of pain signals; it also involves complex processing resulting in amplification and inhibition of noxious input.
Figure 1.2 Central sensitization/potentiation involves the release of excitatory mediators such as substance P and glutamate by spinal afferent nociceptive neurons in the dorsal horn of the spinal cord. These bind to neurokinin-1 (NK1) and N-methyl-D-aspartate (NMDA) receptors, respectively, prompting a massive influx of calcium in the second-order neuron and activating calcium-dependent intracellular enzymes such as protein kinase C, increasing the production of nitric oxide (NO) and prostaglandins. COX, cyclo-oxygenase.
Clinically, this may present as a progressively exaggerated response to stimuli in an area associated with a specific tissue injury; over time, the sensation encompasses the response to stimuli in the surrounding uninjured tissue as well.
Inhibition. Nociceptive signals also travel through the midbrain and brainstem, where descending inhibitory pathways are activated to dampen pain transmission. These inhibitory pathways are stimulated by endogenous opioids, as well as norepinephrine (noradrenaline) and serotonin; these all modulate the release of inhibitory transmitters such as γ-aminobutyric acid (GABA), glycine, adenosine and additional endogenous opioids at the spinal level. In addition, pain elicits a stress hormone response that promotes the secretion of endogenous opioids from the anterior pituitary and adrenal medulla.
Non-nociceptive pain
Non-nociceptive pain may be divided into neuropathic and psychogenic, with neuropathic pain being further categorized as peripheral or central, depending on the pathogenic mechanism. Psychogenic pain should be considered as a diagnosis of exclusion, when no other nociceptive or neuropathic mechanism can be identified and there are sufficient psychological symptoms to meet the criteria for a somatoform or other defined psychological disorder.
Neuropathic pain is frequently described as burning, tingling, electrical or