Hypertrichosis, (Werewolf syndrome) A Simple Guide To The Condition, Diagnosis, Treatment And Related Conditions

By Kenneth Kee

This book describes Hypertrichosis (Werewolf syndrome), Diagnosis and Treatment and Related Diseases

While reading about genetic diseases, I came across this disease called hypertrichosis (which means excessive hairs on the body)
There was also a story in the Middle Ages of a family originally from Canary Islands with a father Petros Gonzales who look like a wolf man and his normal wife and 2 daughters who were as hairy as the father.
It reminded me of the story Beauty and the Beast.

Hypertrichosis, also called werewolf syndrome, is a disorder featured by excessive hair growth anywhere on a person’s body
Hypertrichosis can be congenital (present at birth) or acquired (arises later in life).
The unusual hair growth may cover the face and body or happen in small patches.
Congenital hypertrichosis
This is a genetic disease that is be inherited in an autosomal dominant manner.
Using fluorescence in situ hybridization (FISH), doctors identified a pericentric inversion of chromosome 8, inv (8) (p11.2q22) with an insertion of the q23-24 region into a more proximal region of the long arm of chromosome 8, most probably at the q13 band, and a complex deletion in 8q23 encompassing four separate chromosomal breakpoints
A mutation in MAP2K6 is believed to cause Terminal Hypertrichosis.

Acquired hypertrichosis
Unlike congenital hypertrichosis, the acquired form of the disease is likely to form later in life.
It causes 2 types of hair other than lanugo: vellus hair or terminal hair.
Excessive hair may form in small patches or on all hair-growing regions of a person’s body.
Acquired hypertrichosi depicts excess hair growth that forms in a person after birth.
The hair is normally un-pigmented vellus hair or may have pigmented terminal hair.
Excess hair growth may be localized to a particular region or generalized and spreading over all hair-bearing areas of the body.
Drugs most often produce acquired generalized hypertrichosis:
1. Antibiotics such as streptomycin
2. Anti-inflammatory drugs such as benoxaprofen and corticosteroids
3. Vasodilators (diazoxide, minoxidil, prostaglandin E1)
4. Diuretics (acetazolamide)
5. Anticonvulsants (phenytoin)
6. Immunosuppressives (cyclosporine, mycophenolate mofetil)
7. Psoralens (methoxypsoralen, trimethylpsoralen)
8. Antiseptic agents (hexachlorobenzene)
9. Chelators (penicillamine)
10. Interferon-alpha
11. Fenoterol
12. EGFR inhibitors (cetuximab, panitumumab, erlotinib, gefitinib)
While drugs are normally the cause, acquired generalized hypertrichosis can also be observed in:
1. Traumatic brain injuries,
2. Juvenile hypothyroidism,
3. Juvenile dermatomyositis,
4. Acromegaly,
5. Malnutrition, and
6. Advanced HIV infection.
The diagnosis of hypertrichosis is made on medical and histological findings of the hair
Lanugo hairs are likely to be non-pigmented.
Vellus hair can be pigmented or non-pigmented
Treatment
The medical treatment of eflornithine (Vaniqa cream) 13.9% or the hair removal by methods of repeated shaving, depilatory methods (e.g., chemical, electric methods), or bleaching can cause an improvement in the hypertrichosis patient's appearance.
Antidepressant medicines may be required in patients with psychological depression.
Laser hair removal has been indicated as a treatment method but there are conflicting reports about the efficacy of lasers in eliminating the vellus hairs in congenital hypertrichosis lanuginosa.
40-80% reduction in unwanted hair is obtained using the Q-switched Nd:YAG laser after the application of a topical carbon-based solution.
This therapy is a well-tolerated method of hair removal in children since the lower fluencies required led to reduced pain during treatment

TABLE OF CONTENT
Introduction
Chapter 1 Hypertrichosis (Werewolf syndrome)
Chapter 2 Causes
Cha

• Language: English
• Publisher: Kenneth Kee
• Release date: Dec 7, 2019
• ISBN: 9780463346020

Kenneth Kee

Medical doctor since 1972.Started Kee Clinic in 1974 at 15 Holland Dr #03-102, relocated to 36 Holland Dr #01-10 in 2009.Did my M.Sc (Health Management ) in 1991 and Ph.D (Healthcare Administration) in 1993.Dr Kenneth Kee is still working as a family doctor at the age of 74However he has reduced his consultation hours to 3 hours in the morning and 2 hours inthe afternoon.He first started writing free blogs on medical disorders seen in the clinic in 2007 on http://kennethkee.blogspot.com.His purpose in writing these simple guides was for the health education of his patients which is also his dissertation for his Ph.D (Healthcare Administration). He then wrote an autobiography account of his journey as a medical student to family doctor on his other blog http://afamilydoctorstale.blogspot.comThis autobiography account “A Family Doctor’s Tale” was combined with his early “A Simple Guide to Medical Disorders” into a new Wordpress Blog “A Family Doctor’s Tale” on http://ken-med.com.From which many free articles from the blog was taken and put together into 1000 eBooks.He apologized for typos and spelling mistakes in his earlier books.He will endeavor to improve the writing in futures.Some people have complained that the simple guides are too simple.For their information they are made simple in order to educate the patients.The later books go into more details of medical disorders.He has published 1000 eBooks on various subjects on health, 1 autobiography of his medical journey, another on the autobiography of a Cancer survivor, 2 children stories and one how to study for his nephew and grand-daughter.The purpose of these simple guides is to educate patient on health disorders and not meant as textbooks.He does not do any night duty since 2000 ever since Dr Tan had his second stroke.His clinic is now relocated to the Buona Vista Community Centre.The 2 units of his original clinic are being demolished to make way for a new Shopping Mall.He is now doing some blogging and internet surfing (bulletin boards since the 1980's) startingwith the Apple computer and going to PC.The entire PC is upgraded by himself from XT to the present Pentium duo core.The present Intel i7 CPU is out of reach at the moment because the CPU is still expensive.He is also into DIY changing his own toilet cistern and other electric appliance.His hunger for knowledge has not abated and he is a lifelong learner.The children have all grown up and there are 2 grandchildren who are even more technically advanced than the grandfather where mobile phones are concerned.This book is taken from some of the many articles in his blog (now with 740 posts) A Family Doctor’s Tale.Dr Kee is the author of:"A Family Doctor's Tale""Life Lessons Learned From The Study And Practice Of Medicine""Case Notes From A Family Doctor"

Book preview

Hypertrichosis,

(Werewolf syndrome)

A

Simple

Guide

To

The Condition,

Diagnosis,

Treatment

And

Related Conditions

By

Dr Kenneth Kee

M.B.,B.S. (Singapore)

Ph.D (Healthcare Administration)

Copyright Kenneth Kee 2019 Smashwords Edition,

Published by Kenneth Kee at Smashwords.com

Dedication

This book is dedicated

To my wife Dorothy

And my children

Carolyn, Grace

And Kelvin

This book describes Hypertrichosis (Werewolf syndrome), Diagnosis and Treatment and Related Diseases which is seen in some of my patients in my Family Clinic.

(What You Need to Treat Hypertrichosis (Werewolf syndrome)

This e-Book is licensed for your personal enjoyment only. This eBook may not be re-sold or given away to other people. If you would like to share this book with another person, please purchase an additional copy for each reader.

If you’re reading this book and did not purchase it, or it was not purchased for your use only, then please return to Smashwords.com and purchase your own copy.

Thank you for respecting the hard work of this author.

Introduction

I have been writing medical articles for my blog: http://kennethkee.blogspot.com (A Simple Guide to Medical Disorder) for the benefit of my patients since 2007.

My purpose in writing these simple guides was for the health education of my patients.

Health Education was also my dissertation for my Ph.D (Healthcare Administration).

I then wrote an autobiography account of my journey as a medical student to family doctor on my other blog: http://afamilydoctorstale.blogspot.com.

This autobiography account A Family Doctor’s Tale was combined with my early A Simple Guide to Medical Disorders into a new Wordpress Blog A Family Doctor’s Tale on http://kenkee481.wordpress.com.

From which many free articles from the blog was taken and put together into 800 eBooks.

Some people have complained that the simple guides are too simple.

For their information they are made simple in order to educate the patients.

The later books go into more details of medical disorders.

The first chapter is always from my earlier blogs which unfortunately tends to have typos and spelling mistakes.

Since 2013, I have tried to improve my spelling and writing.

As I tried to bring the patient the latest information about a disorder or illness by reading the latest journals both online and offline, I find that I am learning more and improving on my own medical knowledge in diagnosis and treatment for my patients.

Just by writing all these simple guides I find that I have learned a lot from your reviews (good or bad), criticism and advice.

I am sorry for the repetitions in these simple guides as the second chapters onwards have new information as compared to my first chapter taken from my blog.

I also find repetition definitely help me and maybe some readers to remember the facts in the books more easily.

I apologize if these repetitions are irritating to some readers.

Chapter 1

Hypertrichosis

What is Hypertrichosis?

Hypertrichosis, also called werewolf syndrome, is a disorder featured by excessive hair growth anywhere on a person’s body.

Hypertrichosis is excessive hair growth over and above the standard range for the age, sex and race of a person.

It is important to differentiate hypertrichosis from hirsutism, which is a term used for females who grow an excessive quantity of terminal hairs in androgen-dependent sites.

It can involve both women and men, but it is very rare.

Hypertrichosis can be congenital (present at birth) or acquired (arises later in life).

The unusual hair growth may cover the face and body or happen in small patches.

What are the causes of Hypertrichosis?

Cause

The cause of hypertrichosis is not known.

The causes of hypertrichosis are not clear though there is a form of the disease that is likely to run in families.

Congenital hypertrichosis may be produced by reactivation of genes that cause hair