Ebook290 pages5 hours
Cellular Organelles and the Extracellular Matrix
Rating: 0 out of 5 stars
()
About this ebook
This volume is in two parts. The first contains the remaining chapters on cellular organelles and several chapters relating to organelle disorders. An account of mitochondriopathis is given in the chapter on the mitochondrion rather than in a separate one. The subject matter of this part of the volume shows quite clearly that the interdisciplinary approach to the study of organelles has shed considerable light on the nature of the mechanisms underlying the etiology and pathobiology of many of these disorders. As an example, mutations in the genes encoding integral membrane proteins are found to lead to disturbances in peroxisome assembly. It is also interesting and significant that mistargeting of protein is now thought to be another cause. It will be revealing to see whether mistargeting is the result of mutations in the genes encoding chaperones.
The second part of the volume is concerned with the extracellular matrix. It sets out to show that a vast body of new knowledge of the extracellular matrix is available to us. Take for example the integrin family of cell adhesion receptors. It turns out that integrins play a key role not only in adhesion but also in coupling signals to the nucleus via the cytoskeleton. As for fibronectins, they seem to link the matrix with the cytoskeleton by interacting with integrins.
Collagen molecules are dealt with in the last two chapters. The boundaries of collagen in disease are defined by drawing a clear line of demarcation between systemic connective tissue disorders (e.g., scleroderma), better known as autoimmune diseases, and the heritable, and the heritable diseases such as osteogenesis imperfect and the Marfan syndrome. This classification takes into account a second group of acquired disorders of collagen forming tissues in which regional fibrosis is the hallmark. Liver cirrhosis and pulmonary fibrosis are prime examples.
The decision to place Volumes 2 and 3 before those dealing with cell chemistry was not easily made. It was based on the view that most students will have had an undergraduate course in biochemistry of cell biology or both courses, and that they could go to Volumes 4-7 in which the subject of cell chemistry is covered, and then return to Volumes 2 and 3.
The second part of the volume is concerned with the extracellular matrix. It sets out to show that a vast body of new knowledge of the extracellular matrix is available to us. Take for example the integrin family of cell adhesion receptors. It turns out that integrins play a key role not only in adhesion but also in coupling signals to the nucleus via the cytoskeleton. As for fibronectins, they seem to link the matrix with the cytoskeleton by interacting with integrins.
Collagen molecules are dealt with in the last two chapters. The boundaries of collagen in disease are defined by drawing a clear line of demarcation between systemic connective tissue disorders (e.g., scleroderma), better known as autoimmune diseases, and the heritable, and the heritable diseases such as osteogenesis imperfect and the Marfan syndrome. This classification takes into account a second group of acquired disorders of collagen forming tissues in which regional fibrosis is the hallmark. Liver cirrhosis and pulmonary fibrosis are prime examples.
The decision to place Volumes 2 and 3 before those dealing with cell chemistry was not easily made. It was based on the view that most students will have had an undergraduate course in biochemistry of cell biology or both courses, and that they could go to Volumes 4-7 in which the subject of cell chemistry is covered, and then return to Volumes 2 and 3.
Related to Cellular Organelles and the Extracellular Matrix
Titles in the series (12)
Cell Chemistry and Physiology: Part III Rating: 0 out of 5 stars0 ratingsCellular Organelles Rating: 0 out of 5 stars0 ratingsCellular Organelles and the Extracellular Matrix Rating: 0 out of 5 stars0 ratingsCell Chemistry and Physiology: Part II Rating: 0 out of 5 stars0 ratingsCell Chemistry and Physiology: Part IV Rating: 0 out of 5 stars0 ratingsCell Chemistry and Physiology: Part I Rating: 5 out of 5 stars5/5Microbiology Rating: 4 out of 5 stars4/5Membranes and Cell Signaling Rating: 0 out of 5 stars0 ratingsImmunobiology Rating: 2 out of 5 stars2/5Development Biology Rating: 5 out of 5 stars5/5Biological Psychiatry Rating: 5 out of 5 stars5/5Reproductive Endocrinology and Biology Rating: 0 out of 5 stars0 ratings
Related ebooks
Receptors For Extracellular Matrix Rating: 0 out of 5 stars0 ratingsChemistry of Metalloproteins: Problems and Solutions in Bioinorganic Chemistry Rating: 0 out of 5 stars0 ratingsThe Mechanism of Life Rating: 0 out of 5 stars0 ratingsA New Look at Mechanisms in Bioenergetics Rating: 0 out of 5 stars0 ratingsHuman Liver: Pathophysiology Rating: 0 out of 5 stars0 ratingsMetabolic Syndrome and Cardiovascular Disease Rating: 0 out of 5 stars0 ratingsCell Chemistry and Physiology: Part III Rating: 0 out of 5 stars0 ratingsCell Chemistry and Physiology: Part IV Rating: 0 out of 5 stars0 ratingsCellular Organelles Rating: 0 out of 5 stars0 ratingsCell Chemistry and Physiology: Part I Rating: 5 out of 5 stars5/5Development Biology Rating: 5 out of 5 stars5/5Immunobiology Rating: 2 out of 5 stars2/5Reproductive Endocrinology and Biology Rating: 0 out of 5 stars0 ratingsMembranes and Cell Signaling Rating: 0 out of 5 stars0 ratingsTransmembrane Receptors and Channels Rating: 0 out of 5 stars0 ratingsRetinoids: Their Physiological Function and Therapeutic Potential Rating: 0 out of 5 stars0 ratingsMicrobiology Rating: 4 out of 5 stars4/5The Adhesive Interaction of Cells Rating: 0 out of 5 stars0 ratingsProtein Structural Biology in Biomedical Research, Part A Rating: 4 out of 5 stars4/5Protein Targeting to Mitochondria Rating: 0 out of 5 stars0 ratingsMyocardial Preservation and Cellular Adaptation Rating: 5 out of 5 stars5/5Vectors: A Survey of Molecular Cloning Vectors and Their Uses Rating: 0 out of 5 stars0 ratingsGenetics and Biochemistry of Antibiotic Production Rating: 0 out of 5 stars0 ratingsCell Cycle Rating: 5 out of 5 stars5/5Advances in Structural Biology Rating: 0 out of 5 stars0 ratingsEndocytosis and Exocytosis Rating: 0 out of 5 stars0 ratingsPhagocytosis: The Host Rating: 0 out of 5 stars0 ratingsAdvances in Molecular and Cellular Endocrinology Rating: 0 out of 5 stars0 ratingsBiology of Methylotrophs Rating: 0 out of 5 stars0 ratingsVaccines: New Approaches to Immunological Problems Rating: 5 out of 5 stars5/5
Biology For You
Dopamine Detox: Biohacking Your Way To Better Focus, Greater Happiness, and Peak Performance Rating: 3 out of 5 stars3/5Your Brain: A User's Guide: 100 Things You Never Knew Rating: 4 out of 5 stars4/5Sapiens: A Brief History of Humankind Rating: 4 out of 5 stars4/5Anatomy and Physiology For Dummies Rating: 4 out of 5 stars4/5Fantastic Fungi: How Mushrooms Can Heal, Shift Consciousness, and Save the Planet Rating: 5 out of 5 stars5/5Nursing Anatomy & Physiology Rating: 4 out of 5 stars4/5Ultralearning: Master Hard Skills, Outsmart the Competition, and Accelerate Your Career Rating: 4 out of 5 stars4/5This Will Make You Smarter: 150 New Scientific Concepts to Improve Your Thinking Rating: 4 out of 5 stars4/5Anatomy 101: From Muscles and Bones to Organs and Systems, Your Guide to How the Human Body Works Rating: 4 out of 5 stars4/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Why We Sleep: Unlocking the Power of Sleep and Dreams Rating: 4 out of 5 stars4/5How Emotions Are Made: The Secret Life of the Brain Rating: 4 out of 5 stars4/5All That Remains: A Renowned Forensic Scientist on Death, Mortality, and Solving Crimes Rating: 4 out of 5 stars4/5The Obesity Code: the bestselling guide to unlocking the secrets of weight loss Rating: 4 out of 5 stars4/5The Grieving Brain: The Surprising Science of How We Learn from Love and Loss Rating: 4 out of 5 stars4/5Genius Kitchen: Over 100 Easy and Delicious Recipes to Make Your Brain Sharp, Body Strong, and Taste Buds Happy Rating: 0 out of 5 stars0 ratingsThe Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race Rating: 4 out of 5 stars4/5The Soul of an Octopus: A Surprising Exploration into the Wonder of Consciousness Rating: 4 out of 5 stars4/5Homo Deus: A Brief History of Tomorrow Rating: 4 out of 5 stars4/5Mother of God: An Extraordinary Journey into the Uncharted Tributaries of the Western Amazon Rating: 4 out of 5 stars4/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5A Crack In Creation: Gene Editing and the Unthinkable Power to Control Evolution Rating: 4 out of 5 stars4/5Written in Bone: Hidden Stories in What We Leave Behind Rating: 4 out of 5 stars4/5Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness Rating: 4 out of 5 stars4/5The Blood of Emmett Till Rating: 4 out of 5 stars4/5Lifespan: Why We Age—and Why We Don't Have To Rating: 4 out of 5 stars4/5The Winner Effect: The Neuroscience of Success and Failure Rating: 5 out of 5 stars5/5Woman: An Intimate Geography Rating: 4 out of 5 stars4/5The Coming Plague: Newly Emerging Diseases in a World Out of Balance Rating: 4 out of 5 stars4/5
Reviews for Cellular Organelles and the Extracellular Matrix
Rating: 0 out of 5 stars
0 ratings
0 ratings0 reviews
Book preview
Cellular Organelles and the Extracellular Matrix - Elsevier Science
Enjoying the preview?
Page 1 of 1