The Chemokine Factsbook: Ligands and Receptors
()
About this ebook
How do you keep track of basic information on the proteins you work with? Where do you find details of their physicochemical properties, amino acid sequences, gene organization? Are you tired of scanning review articles, primary papers and databases to locate that elusive fact?
The Academic Press FactsBook series will satisfy scientists and clinical researchers suffering from information overload. Each volume provides a catalog of the essential properties of families of molecules. Gene organization, amino acid sequences, physicochemical properties, and biological activity are presented using a common, easy-to-follow format. Taken together they compile everything you want to know about proteins but are too busy to look for. The Chemokine FactsBook contains more than 40 entries on chemokines, and chemokine receptors from human or other origin, including IL-8, MCP-1, C5-a, RANTES, Lymphotactin, and CC CKR-1.
The text provides information on tissue sources, target cells, physicochemical properties, transcription factors, regulation of expression in disease, receptor-binding characteristics, gene structure and location, amino acid sequences, and accession numbers and references.
- Contains over 40 entries on chemokines and chemokine receptors from human or other origin, including:
- IL-8
- MCP-1
- C5-a
- RANTES
- Lymphotactin
- CC CKR-1
- Entries provide information on:
- Tissue sources
- Target cells
- Physicochemical properties
- Transcription factors
- Regulation of expression
- Expression in disease
- Receptor-binding characteristics
- Gene structure and location
- Amino acid sequences
- Database accession numbers
- References
Related to The Chemokine Factsbook
Titles in the series (17)
Ion Channel Factsbook: Extracellular Ligand-Gated Channels Rating: 0 out of 5 stars0 ratingsIon Channel Factsbook: Voltage-Gated Channels Rating: 0 out of 5 stars0 ratingsThe Gene Knockout Factsbook, Two-Volume Set Rating: 0 out of 5 stars0 ratingsThe HLA FactsBook Rating: 0 out of 5 stars0 ratingsThe Adhesion Molecule FactsBook Rating: 0 out of 5 stars0 ratingsThe Cytokine Factsbook and Webfacts Rating: 0 out of 5 stars0 ratingsThe Chemokine Factsbook: Ligands and Receptors Rating: 0 out of 5 stars0 ratingsThe Leucocyte Antigen Factsbook Rating: 0 out of 5 stars0 ratingsThe Extracellular Matrix Factsbook Rating: 0 out of 5 stars0 ratingsThe Oncogene and Tumour Suppressor Gene Factsbook Rating: 0 out of 5 stars0 ratingsThe T Cell Receptor FactsBook Rating: 0 out of 5 stars0 ratingsThe Leukemia-Lymphoma Cell Line Factsbook Rating: 0 out of 5 stars0 ratingsThe Blood Group Antigen FactsBook Rating: 4 out of 5 stars4/5The Nuclear Receptor FactsBook Rating: 0 out of 5 stars0 ratingsThe Transporter Factsbook Rating: 0 out of 5 stars0 ratingsThe Immunoglobulin FactsBook Rating: 0 out of 5 stars0 ratingsThe Complement FactsBook Rating: 0 out of 5 stars0 ratings
Related ebooks
The Cytokine Factsbook and Webfacts Rating: 0 out of 5 stars0 ratingsImmunogenetics: A Molecular and Clinical Overview: A Molecular Approach to Immunogenetics Rating: 0 out of 5 stars0 ratingsImmunogenetics: A Molecular and Clinical Overview: Clinical Applications of Immunogenetics Rating: 0 out of 5 stars0 ratingsGrowth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy Rating: 0 out of 5 stars0 ratingsUnderstanding Cancer: From Basics to Therapeutics Rating: 5 out of 5 stars5/5Lymphocyte Differentiation, Recognition, and Regulation Rating: 0 out of 5 stars0 ratingsFast Facts: Immuno-Oncology Rating: 0 out of 5 stars0 ratingsMechanisms of Chemical Carcinogenesis Rating: 0 out of 5 stars0 ratingsProtein Kinase Inhibitors as Sensitizing Agents for Chemotherapy Rating: 0 out of 5 stars0 ratingsStem Cell Epigenetics Rating: 0 out of 5 stars0 ratingsSignal Transduction Rating: 5 out of 5 stars5/5Antibody Fc: Linking Adaptive and Innate Immunity Rating: 0 out of 5 stars0 ratingsCell Culture for Biochemists Rating: 0 out of 5 stars0 ratingsCancer Cytogenetics: Chromosomal and Molecular Genetic Aberrations of Tumor Cells Rating: 0 out of 5 stars0 ratingsThe Immunoglobulin FactsBook Rating: 0 out of 5 stars0 ratingsThe Leucocyte Antigen Factsbook Rating: 0 out of 5 stars0 ratingsAntigens, Lymphoid Cells and the Immune Response Rating: 0 out of 5 stars0 ratingsFrontiers in Clinical Drug Research - Hematology: Volume 4 Rating: 0 out of 5 stars0 ratingsEmery and Rimoin’s Principles and Practice of Medical Genetics and Genomics: Perinatal and Reproductive Genetics Rating: 0 out of 5 stars0 ratingsThe T Cell Receptor FactsBook Rating: 0 out of 5 stars0 ratingsMolecular Biology of B Cells Rating: 0 out of 5 stars0 ratingsThe End of the Beginning Rating: 0 out of 5 stars0 ratingsThe HLA FactsBook Rating: 0 out of 5 stars0 ratingsMolecular Protocols in Transfusion Medicine Rating: 0 out of 5 stars0 ratingsImmune Biology of Allogeneic Hematopoietic Stem Cell Transplantation: Models in Discovery and Translation Rating: 0 out of 5 stars0 ratingsInflammasome Biology: Fundamentals, Role in Disease States, and Therapeutic Opportunities Rating: 0 out of 5 stars0 ratingsThe Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology Rating: 0 out of 5 stars0 ratingsVaccines for Cancer Immunotherapy: An Evidence-Based Review on Current Status and Future Perspectives Rating: 0 out of 5 stars0 ratingsAACR 2016: Abstracts 1-2696 Rating: 0 out of 5 stars0 ratingsCell Press Reviews: Core Concepts in Cell Biology Rating: 0 out of 5 stars0 ratings
Medical For You
Mating in Captivity: Unlocking Erotic Intelligence Rating: 4 out of 5 stars4/5The 40 Day Dopamine Fast Rating: 4 out of 5 stars4/5The Lost Book of Simple Herbal Remedies: Discover over 100 herbal Medicine for all kinds of Ailment Inspired By Barbara O'Neill Rating: 0 out of 5 stars0 ratingsMediterranean Diet Meal Prep Cookbook: Easy And Healthy Recipes You Can Meal Prep For The Week Rating: 5 out of 5 stars5/5Tight Hip Twisted Core: The Key To Unresolved Pain Rating: 4 out of 5 stars4/5Holistic Herbal: A Safe and Practical Guide to Making and Using Herbal Remedies Rating: 4 out of 5 stars4/5Adult ADHD: How to Succeed as a Hunter in a Farmer's World Rating: 4 out of 5 stars4/5The Vagina Bible: The Vulva and the Vagina: Separating the Myth from the Medicine Rating: 5 out of 5 stars5/5The Amazing Liver and Gallbladder Flush Rating: 5 out of 5 stars5/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Living Daily With Adult ADD or ADHD: 365 Tips o the Day Rating: 5 out of 5 stars5/5What Happened to You?: Conversations on Trauma, Resilience, and Healing Rating: 4 out of 5 stars4/5The Diabetes Code: Prevent and Reverse Type 2 Diabetes Naturally Rating: 4 out of 5 stars4/5ATOMIC HABITS:: How to Disagree With Your Brain so You Can Break Bad Habits and End Negative Thinking Rating: 5 out of 5 stars5/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5The Hormone Reset Diet: Heal Your Metabolism to Lose Up to 15 Pounds in 21 Days Rating: 4 out of 5 stars4/5David D. Burns’ Feeling Good: The New Mood Therapy | Summary Rating: 4 out of 5 stars4/5Lifting the Fog: A specific guide to inattentive ADHD in adults Rating: 4 out of 5 stars4/5The Butchering Art: Joseph Lister's Quest to Transform the Grisly World of Victorian Medicine Rating: 4 out of 5 stars4/5The White Coat Investor: A Doctor's Guide to Personal Finance and Investing Rating: 4 out of 5 stars4/5The Song of the Cell: An Exploration of Medicine and the New Human Rating: 4 out of 5 stars4/5Herbal Healing for Women Rating: 4 out of 5 stars4/5Women With Attention Deficit Disorder: Embrace Your Differences and Transform Your Life Rating: 5 out of 5 stars5/5The Gene: An Intimate History Rating: 4 out of 5 stars4/5
Related categories
Reviews for The Chemokine Factsbook
0 ratings0 reviews
Book preview
The Chemokine Factsbook - Krishna Vaddi
acetate
1
Introduction
AIM OF THE BOOK
The primary goal of this book is to provide researchers with a source of comprehensive information on the rapidly evolving family of intercellular mediators known as ‘chemokines’. As new proteins of biological importance are being identified almost every day, it is nearly impossible to keep up with their functions and other facts that make them useful tools in our daily research. These proteins are exquisitely specific in their effects on cell types and the responses they elicit. We often find ourselves digging through the literature to find what they do, how they are regulated and how they could be mediating the effects we find in our own research. The authors of the previously published Cytokine FactsBook did a phenomenal job of putting together most of the facts on cytokines and included extensive information on chemokines as well. We have tried to make the present book complementary to the Cytokine FactsBook by providing more detailed information on the biological effects, regulation of expression, expression in different disease states (both human diseases and animal models), in addition to the basic facts that readers have come to expect from a book in this series.
HOW DO CHEMOKINES DIFFER FROM CYTOKINES?
Although still considered as members of the cytokine superfamily, chemokines are rapidly establishing their own identity as a class of molecules with very distinct effects. The name chemokine comes from a combination of chemotactic and cytokines and chemotaxis or signaling for directed migration has been the central concept, besides the structural similarities, that distinguishes this class of proteins as a family. It is clearly established that many pathological as well as physiological processes are closely regulated by a given cell type, and scientists have long wondered about the signals that could specifically draw a given cell into a given tissue. As Schall aptly put it ‘Like the physicists’ dark matter, the existence of chemokines had been long suspected, but their nature in the immunological cosmos was undefined until recently’¹.
With the identification of IL-8, which is chemotactic to granulocytes but not monocytes, it appeared clearly possible to have a protein that could specifically deliver a migratory signal to a specific cell type. This finding was in sharp contrast to those that show lack of cell specificity such as formyl peptides, C5a, and LTB4. Discovery of MCP-1 represents another important milestone in the evolution of the chemokine family. MCP-1 is primarily chemotactic to mononuclear leukocytes but not polymorphs, and hence seen to play an important role in chronic inflammatory diseases. Identification of IL-8 and MCP-1 marks a new era in chemotaxis biology, and serious efforts have begun to explore other proteins such as those that could be chemotactic to other cell types.
Another important turning point for the chemokine field came about with the identification of heptahelical receptors for IL-8. Subsequently several chemokine receptors have been identified, and as far as we know today, chemokines are the only members of the cytokine superfamily that bind to receptors that are seven-transmembrane and G-protein coupled in nature; another feature that makes the chemokines distinct. These findings also opened up a whole new area of research exploring new chemokine receptors and how each of the chemokines interacts with their receptors. Intense research is currently focused on understanding the specificity of chemokines and their receptors utilizing structural and functional studies with the goal of identifying of molecules that could specifically modulate receptor–ligand interactions.
However, as of today, we are not really sure if the most important physiological function of chemokines is chemotaxis alone. Recent findings² on the molecular basis of the angiogenic and the angiostatic effects of chemokines have sparked a great interest in their role in physiological and pathological conditions that require neovascularization. Even more recently, the discovery of a relationship between β-chemokines and the resistance to human immunodeficiency virus infection³ has created newer avenues of scientific exploration of the real biological role of chemokines. Other novel biological effects of chemokines such as T-cell costimulatory effects are also beginning to