In rare case, patient developed resistance to CAR-T after cancer cell began hiding in ‘plain sight’
In a rare case, a patient developed resistance to CAR-T therapy after his cancer cell began hiding in "plain sight."
To make CAR-T therapies, the pioneering cancer treatments, scientists introduce a gene into the body’s immune cells that turns them into cancer-homing attackers. But in one case described by scientists Monday, the gene was inadvertently delivered to a cancer cell instead, camouflaging it from the therapy and allowing the cancer to develop resistance to treatment.
The patient ultimately died.
The case, in the journal Nature Medicine, appears to have been exceedingly rare — one occurrence among of CAR-T treatment that have been examined.
