Discover millions of ebooks, audiobooks, and so much more with a free trial

Only $11.99/month after trial. Cancel anytime.

Leukodystrophies
Leukodystrophies
Leukodystrophies
Ebook518 pages4 hours

Leukodystrophies

Rating: 0 out of 5 stars

()

Read preview

About this ebook

The leukodystrophies are serious, progressive disorders of demyelination, manifesting themselves in infancy or early childhood and progressing rapidly, leading to loss of sight, hearing, speech, and ambulation, and early death. A comprehensive guide to the genetics and pathogenesis of these disorders, as well as their clinical features, diagnosis and therapy, is needed, particularly as their early identification can allow more effective treatment.

This book is the only up-to-date, comprehensive text on leukodystrophies. Its purpose is to summarize for the reader all aspects of the inherited disorders of myelin in children and adults. After a comprehensive overview of myelin and the role of oligodendrocytes, astrocytes and microglia in white matter disease, chapters are then devoted to individual disorders, covering their biochemical and molecular basis, genetics, pathophysiology, clinical features, diagnosis, treatment and screening. The final chapters address therapeutic approaches in leukodystrophies and present a clinical approach to diagnosing leukoencephalopathies in children and adults. The book was conceived by Hugo Moser, whose research led to major developments in the treatment of adrenoleukodystrophy, and is dedicated to him by his colleagues.

LanguageEnglish
Release dateMar 2, 2011
ISBN9781907655456
Leukodystrophies

Related to Leukodystrophies

Related ebooks

Medical For You

View More

Related articles

Reviews for Leukodystrophies

Rating: 0 out of 5 stars
0 ratings

0 ratings0 reviews

What did you think?

Tap to rate

Review must be at least 10 words

    Book preview

    Leukodystrophies - Gerald V Raymond

    I]2^book_preview_excerpt.html}YrHV~JcN]VfJI9tjV0Hb~==<qW{ jL"<|<>Oe*~\cTeGi>?~.Xtq/g}9:3_|?EikͪOk>sAYI-]匥l1.j,mc5fqyVoZ6K3[frۼw ݈.UY7)zMv7k2[]`7[ﭫl涢%eaZ6y<^R .˰yv{ ]<*Zcͺ|r}bmE5ilE(k~UViQV+gMF 0a+.}hEo&=tߍY1SG-~1{d3u)g(>ptqSqy;f|k>qd6:JZݳ󣛪uk[7|Yee^.h~IEvO% G]璭9}ͣ6fA[ǥbv̙C tu-5Uc;Ҕܵ|_/ 8-Hd%-GgzY9h/6DL[l@K4'ʕ)o3#d|x,sz+:]:œdE9aMsl<BltG] ?q|bmC7'* `MZWmܮp.d򼠳L&pIYrEa157Du#g6k+uw6a]8QDѢq,%]Bh*50+H94=1s[la M_Wv,dŢaK\3fӬ-݊kWeΰ0Eٮۊ(tO'aTHۑ6qX +'C4o8:ٗ!SBV+IrgbzH0:`|/ ߒV1ETy"Ԕ\^ϖS~rEĮfx|.<9D *v%%i?&hۚ9`BZ |F,[Dѡ\*#'->ij'9^%?DXʌNnrdN:9aё<izjjhc7 H7seȜoB@ȝ]a]JҒ"Y{,$oyNK$ mWLv6WĢ ϪrD)5V6ĞGIqZ!zHBl'DwEȊgk3z&\>׹@e{[ݬdjZ\%b3|9"?|lgd*lFRr:WEnO5g%7KZd̨&Y;yqE1L%ce(1Lے9s%eu]-) hKm>whO&g֖Lܠ\ۆu}<} f ⶝Z^_:qm qh3R9nLxr&D$4X2sƥ{hޓ/I[NUsKJ1ɪN/wOeƕfħΣ."Y[t?w+%dr*stвU\o9@Q:Ίɲ#H*߉6W*=jUeNۊQ";$KlX qf4 IH私CN;̖60~8ergsKzWjJ1y3D֘ڊݎaEDgdnWT.ɷ%R}iߥi1prx~SU6g޵ ,IaHC›CQǕj-QidxPdoՅe>k' _NTs<ᅪ".IcqZ hZm[cDO+z@K}#OVGnJd잍B (+#^75B@}I# 0vOE>Wſt5"]gǔh-G]$#,ǡ lnʦ4 g /#`v#,8F:̊'Җ `T)=eUM 4g/ߌ~=@ A2Ot i6KO b0D'c_;%_bzzn?g O|o{b'[B듺Z %^5ʺEvIU=Qgz<Ǵf$"ؐ?7 6)p:th@goPCb{,rCSj$26"w%Af. Cb@~k+kb4ɳE9w0| ,%B|)qw{:#9-ix 5ڍG#C$v"a*p^ECl$:C Q΂I$K9=b"؂rv_ru{9`CG8Ôl'>0à#V|;.mu4>@'g'/̈pl۔dm׊I!3YYĐk؈p`#PU`]֒I8>&~1@Yb\ܓ ^;xk as3Lnjܢ F]F[nom%4!-_״נ'k џw% pEP%Z`D(``X]Ӊw0DU;+I ydrK|sщ̓T 53}E0]> ,7,ѝ]s㪥]Zh^-)4LqBX;͂4-N"Vuzm`[oᐺGʠR?yY`vBvW49ꐋ&Cnd,J@z*uκ%dSvF7nB1Չ4X's%z DSy=x<䅅' Åֳ+v 8TnUw/,`ZH024Ch%@ni˕P!ΑSxX]LYۊDq(YZ+CTri'DḂ2XEE\W=)@t*z@şέ5Yղg<`RBC2 um moSNn h'9{8/$?|_9{S A8to۰6M8~0HPlM28%оrpfen.iin[$I9|լ> ȑf}`ΙEG8w)Bγԁ%wsSo蹹ķ9cml_37a9١9 9jv䄙ӛ-2\t;1@r^1ENYg٪UI t LSHn+]ߙGoho!hzSj|Zٲ1?n^K_n!F gJCe h:"3#'\2dbN˒L:`(\"nR=whr#@nVC1B"FcXd)&v,[8:~gK_ \lނ gSRw's's Q#Ҋ8M:)ȅKJf g7oorHϓ fc~:1ۆJy=ksĊDl+'$$GL{tH]܁$^`$#9~v=zEL3»v";\o1d+9K{g' 5Ky^\~89rcQYr ֻիCZ{a٬ى_ k?pRml윑#6<\3_pYCg>ćy&y^$@1 2]uʶ$yGWoeY{[=,I!-V6S y'5\t;sp|@k>8kՀT&_'w+}=?=Ԃ}R%yMvJߑK>7 䢠= {1tMs1vLjtEޘ WmF7g#:% ``K x@i3g1a{Nk)Q8 [כqHRZLBE</(=?S(4wP,z kHr.B+$hcyFkSjD\wr" с<Ļs[r!dBF\Y+(c [vGou0j%dWrVt E@kO7 HGb [y`ν'"bql(&Y=@N뎾W)09Y2 -9J _]tdҮ ]#p #TMB5M b]\@ADVch-fM E'[đf.\7$2pbH)0^v ڢ%Js|*Kbۂ7A=;avao&G5tp޵}#V0F&"M iKW )a@b۱oɩ;HUF^p1Д_:$QXH9KkVO(Y_HdIcDR!rR)89jɖm%Twn;p +}%db87&zuug+Izp NpL}8+δ©V#r6fW Z`'O8W;npasFT!3<ٹ(8\2\$8'jLv Vj1CA3(bw*xG$p'hx 2Yt(k4[ΖO@X:HKiy X|b`poSegrMbնN'0TIq'ՂE3nVY?('$u+d)=Uu|IL- 1PqvRgnHo& N+O0'~v(+dPZ3"q^GIu%e\E/q^rR25죒kB '%IH6s(^,vf?`Rp/ STwL=qơ@՟#Ij[A}1>4$zP> Ѓ˶g6d۠QZ(1*Z8Ƹr\)Ȑ/@ n+5z$' ΋o~ńՙ`_xi^dPE .D-NU6Cx ~tEA?Z|J0  oҋ1wD;ds SUq>oRmAgpʯ&r$"oZaoHl W#~@|MC7iJfJdս24r HCrmEXuUYVA b Sh@ۂS#f뾑7zR(U5D|si"ds;'<4 +\K% bXVw"B#/u~LZ Gke{ #oO̧,#5!f%}gΚUD=!,'PQm$ TO>2Z-$mFq1wRzh?#Z3lZiMAS%Xd "vxu.aCm(wTE+8+R%ls)̪S }&f_X KfM^|]@kĈ0dj}tI'4X,t04RIPV 8z\X|åSdZ6n}rCBziS=*$1jvnec6_s,y|\nJ a \^g%W,a~7|}4Ne._z\rv}VK0U?x~Vs;<} 4톋-'nx:JYf|iOǝLU"pIAeEAIW~L㽿HRwߦ62M>~9]uhFl^6MF`aP$b$|7|7S%z`뉾 lo`>~!c&5}ǡNcZk7&%8.er}Uc#n0x*XH Oa4`ݮh@D(*롊%Q/.Ֆ+1nr T„~`DVB]#3-v+caQFGl:wYܝʠ1Yˠ%&ự0 C[6S+r >AcNIg#rҕJM>s("E.e!vDyTw2CT M&''Ί V˩j/ )PZg9%%*['={_t1"us$6kFmss=ᅺJE; „͵J;R̠I;O$G-Œ1m$a0g2?99'Qx\0w߯oo^ߝ M8ma"G@&9̎7c}Suktl,E'ElF's <$B9[ PzF17/gUᕛT2|sA:Z))V!ډIb6Wr7.ULhkx{rQv.ʊQ^O̗gKT( *7{ij>w`83W9B]s9Kl0Q%HZRh:WQ5_ q*7Ux0&9o 6H^I=n9,A:U!AH|)<@ڄa`QWMY[D (3'f+Kr{uB beCܸzf/Gcb(] >cA>ծoWN4±sD o>kDF9Ŵ UY4Aac!5siwpAϻ{D6;7[D|>I2ɴ@Ȥ3l5&3&mC{Lkcl*7?V+0T 8yWH|5:2IszS\HUaT$L /;쒔OmQxi.Y/{ø|e;*0,>#}/ sx o 3Hg3GHry3@E+[.t{ڢѥߜ8er*HEP,J:U4N1jNnAe֔ɢOyVyvoo%@ñsrk_\m0 88  ;њϗ@xޭ>a| aR0g]/@$YT{媬 dR^h]<0kS wAܘeMBpY5t0A-lJ >$sqZ$4G?_wwي8Q :}i6cS!!C6ƫc:>_?xv2f%oe+5{AKL\Og $&Ǵq2JYqܛ4$=Ӽ A[Q1mY]nìzu\EYe:ǣ"3s]RAM|`˿ErIowV׼ҳQWճQR=8aשּׂRklu'dBD$kLp՗}I/9>"lv[Qɞwɍ&@77JEI'yg\E_@ =l)Ct xb7Y>/7Dž\ܗ~.̫o, @f?D CQ]YSp"mkNV)/!x%av) IN=/)жn_)ֵuim.!I㬗>&<! sjU( 61kz<\Rʭs  `ZL ā q3zO Vܹk2Ht8G#]xj;OP Ve(.4&t6:W Eb'PsϯW]?{JDDe*67l%T caEs⣛*{KmR/Ea+]4C+I5ZCH0ƃɘ6aJXX7J[P2 \b4Xl!cqׇw (By)Dl.}8*k̳HHU+땬Һ0cdU6}P>w"JNES2c/Rs|e'L6SOhe\aԥ- >Gtm<Ҡe? 2(͒ckL2. Ɨⱛ#ғ[? v)s^ !56曱^(JՏ$sUa踭7B<٪7ocQi֡oK#Uæ:خm3z̓`d ]1ծz[:Kdё{~9y 1p D:пsh_ېmrQV`I%Ez>>GL새ylZ5#p7~QtB=4"AgnaJ.M77SlXAa4 Ãd'wA3c9p_@ V. xX\{ʴYYOYYw뱞Œq=I#ĥd~`*8=Zkzc \ jI-Bv~4n=D#3$JZ z*V;2z( @.Lx\)#p(6Lꄼ:_ɅA2Oˇ}+ vQ󬁼,C]x^r ,"/TMS~6x1NC #]yInNlڟ-2kӭ ^D Z\ӎROB o] QB!g3W Bnʽ?w>u2 [DB<6`z"$b6Ciy.w>*(Rj K27sN ɤi]PV6z!- xߛ̏,#`$푎f05Y/l?J ^ b1vf{l2 gq@kv.Yk'&92m@*qF=7 ӳ]oōv/}[D|/y\n7&} ΐEp?(XGs[HΊEy-'&Ax^a~6aMxԆ.zI%Hp؈ݲ4ЪTdLl(.=:'H E<>MKvn j`4rI#)5JVR>1׷7Uh.u6FRgWvA)u(G98ݛ$Lf{]֭P[W;R3m/,c.\Yr~vAT^S)Z(5=TĀM7kf&~*N}Ne~^vsc.|4H=xP,զ][έW[J'5W9,z#;APE5?ӫ^P5̦6 h-MYm=Jh]F-}FOLX(BJ*5Q(Q Ub>ՀBcM m:Tmeu[#s\(-&[F1oE$dOS10[Sh*&?FBåT>Vsi'cbZgf3x?fP2 ^{$.8]t&#J1ˏ) "嵂 v*0a ;x b.}zUy|vלnWi_2.EYCu|wV2%=;iRM|G/] Mwį}=ʄ3)$j~To=21LX^ /$U -p|4J%L{Ӡ7 V)<2>iH 6$LP[?r2K oX;.ÄThٌ1/4ˠtdB•G/X)KQcl\7,q1 kg|t+ݎfkޭaQJp Oc<'7uڢby0Vny&V?gx n $wO:rʶoڠ$BX6f]6~~n ˲jfmӁ;(wƋTW^)9d-um N C|IYE?-e9 yoDkmK\FQy`:vkrԍIqWӸwh5+`y>x:s F\h8,}rι}N+)jTIPoVS~-bNAF/C>玉g ?֥
    Enjoying the preview?
    Page 1 of 1