Rating: 0 out of 5 stars
0 ratings
Ebook600 pages21 hours
Transcription Factors: Normal and Malignant Development of Blood Cells
Rating: 0 out of 5 stars
()
About this ebook
Transcription Factors
Normal and Malignant Development of Blood Cells
Katya Ravid and Jonathan Licht
The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias.
This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as:
* Transcription factors and the megakaryocytic, myeloid, and erythroid lineages
* Leukemias due to chromosomal translocations involving gene encoding transcription factors
* Oncogenesis and hematopoiesis
* In vivo studies of transcription factors implicated in hematopoiesis
* And much more
Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Normal and Malignant Development of Blood Cells
Katya Ravid and Jonathan Licht
The role of transcription factors in activating specific genes in blood cells is an important facet of hematopoiesis. Equally important, however, is the pursuit of genes rearranged and aberrantly activated in leukemias (blood malignancies). Transcription Factors: Normal and Malignant Development of Blood Cells focuses on those major transcription factors involved in activation of lineage-specific gene expression during normal versus malignant development of specific blood lineages, as revealed from gene promoter studies, knockout of transcription factors in mice models, and the identification and characterization of chromosomal rearrangement in human blood leukemias.
This complete digest of current transcription factor data offers comprehensive coverage of the myriad of transcription factors in blood cell development, composed by established experts in the field. In addition to updating the reader on the connection between chromosomal translocations involving transcription factors and cellular transformation leading to leukemia, Transcription Factors also reviews such subjects as:
* Transcription factors and the megakaryocytic, myeloid, and erythroid lineages
* Leukemias due to chromosomal translocations involving gene encoding transcription factors
* Oncogenesis and hematopoiesis
* In vivo studies of transcription factors implicated in hematopoiesis
* And much more
Appealing to both the researcher and the clinician in the field of hematology, Transcription Factors is a timely presentation of cell lineage development and sheds light on the processes involved in the development of specific leukemias. Providing insight into the study of transcription factors, readers will gain an understanding of mechanisms that lead to normal lineage commitment and terminal differentiation.
Related to Transcription Factors
Related ebooks
Molecular Hematology Molecular Mechanisms In Cellular Growth and Differentiation Rating: 0 out of 5 stars0 ratingsProgress in Immunology VI: Sixth International Congress of Immunology Rating: 0 out of 5 stars0 ratingsBiochemical and Clinical Aspects of Hemoglobin Abnormalities Rating: 0 out of 5 stars0 ratingsPNH and the GPI-Linked Proteins Rating: 0 out of 5 stars0 ratingsAnimal Virus Genetics Rating: 0 out of 5 stars0 ratingsAntibody Production in Man: In Vitro Synthesis and Clinical Implications Rating: 0 out of 5 stars0 ratingsInterferons Rating: 0 out of 5 stars0 ratingsIntercellular Signaling in Development and Disease: Cell Signaling Collection Rating: 0 out of 5 stars0 ratingsMolecular Mechanisms in the Control of Gene Expression Rating: 0 out of 5 stars0 ratingsInteraction of Translational and Transcriptional Controls in the Regulation of Gene Expression Rating: 0 out of 5 stars0 ratingsExtracellular Matrix Influences on Gene Expression Rating: 0 out of 5 stars0 ratingsNatural Cell-Mediated Immunity Against Tumors Rating: 0 out of 5 stars0 ratingsBacillus Molecular Genetics and Biotechnology Applications Rating: 0 out of 5 stars0 ratingsGenetic Recombination in Cancer Rating: 0 out of 5 stars0 ratingsExtracellular Matrix Rating: 0 out of 5 stars0 ratingsThe Molecular Basis of Mutant Hemoglobin Dysfunction Rating: 0 out of 5 stars0 ratingsAnimal Virology V4 Rating: 0 out of 5 stars0 ratingsDevelopmental Biology Using Purified Genes Rating: 0 out of 5 stars0 ratingsImmune Regulators In Transfer Factor Rating: 0 out of 5 stars0 ratingsMechanisms of Cytotoxicity by NK Cells Rating: 0 out of 5 stars0 ratingsPhagocytosis—past and future Rating: 0 out of 5 stars0 ratingsCell Death Rating: 0 out of 5 stars0 ratingsNonsegmented Negative Strand Viruses: Paramyxoviruses and Rhabdoviruses Rating: 0 out of 5 stars0 ratingsMolecular Cloning and Gene Regulation in Bacilli Rating: 0 out of 5 stars0 ratingsGenetics and Biotechnology of Bacilli Rating: 0 out of 5 stars0 ratingsSignal Transduction and Human Disease Rating: 0 out of 5 stars0 ratingsIons, Cell Proliferation, and Cancer Rating: 0 out of 5 stars0 ratingsModulation of Protein Function Rating: 0 out of 5 stars0 ratingsImmune Recognition Rating: 0 out of 5 stars0 ratings
Biology For You
Lifespan: Why We Age—and Why We Don't Have To Rating: 4 out of 5 stars4/5Why We Sleep: Unlocking the Power of Sleep and Dreams Rating: 4 out of 5 stars4/5Sapiens: A Brief History of Humankind Rating: 4 out of 5 stars4/5Gut: The Inside Story of Our Body's Most Underrated Organ (Revised Edition) Rating: 4 out of 5 stars4/5The Winner Effect: The Neuroscience of Success and Failure Rating: 5 out of 5 stars5/5The Sixth Extinction: An Unnatural History Rating: 4 out of 5 stars4/5Lies My Gov't Told Me: And the Better Future Coming Rating: 4 out of 5 stars4/5Ultralearning: Master Hard Skills, Outsmart the Competition, and Accelerate Your Career Rating: 4 out of 5 stars4/5The Soul of an Octopus: A Surprising Exploration into the Wonder of Consciousness Rating: 4 out of 5 stars4/5Dopamine Detox: Biohacking Your Way To Better Focus, Greater Happiness, and Peak Performance Rating: 3 out of 5 stars3/5Woman: An Intimate Geography Rating: 4 out of 5 stars4/5Fantastic Fungi: How Mushrooms Can Heal, Shift Consciousness, and Save the Planet Rating: 5 out of 5 stars5/5"Cause Unknown": The Epidemic of Sudden Deaths in 2021 & 2022 Rating: 5 out of 5 stars5/5The Grieving Brain: The Surprising Science of How We Learn from Love and Loss Rating: 4 out of 5 stars4/5The Obesity Code: the bestselling guide to unlocking the secrets of weight loss Rating: 4 out of 5 stars4/5All That Remains: A Renowned Forensic Scientist on Death, Mortality, and Solving Crimes Rating: 4 out of 5 stars4/5Peptide Protocols: Volume One Rating: 4 out of 5 stars4/5Anatomy 101: From Muscles and Bones to Organs and Systems, Your Guide to How the Human Body Works Rating: 4 out of 5 stars4/5A Crack In Creation: Gene Editing and the Unthinkable Power to Control Evolution Rating: 4 out of 5 stars4/5Homo Deus: A Brief History of Tomorrow Rating: 4 out of 5 stars4/5The Blood of Emmett Till Rating: 4 out of 5 stars4/5The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race Rating: 4 out of 5 stars4/5How Emotions Are Made: The Secret Life of the Brain Rating: 4 out of 5 stars4/5A Letter to Liberals: Censorship and COVID: An Attack on Science and American Ideals Rating: 3 out of 5 stars3/5Mother of God: An Extraordinary Journey into the Uncharted Tributaries of the Western Amazon Rating: 4 out of 5 stars4/5This Will Make You Smarter: 150 New Scientific Concepts to Improve Your Thinking Rating: 4 out of 5 stars4/5Fatal Invention: How Science, Politics, and Big Business Re-create Race in the Twenty-First Century Rating: 4 out of 5 stars4/5Suicidal: Why We Kill Ourselves Rating: 4 out of 5 stars4/5Other Minds: The Octopus, the Sea, and the Deep Origins of Consciousness Rating: 4 out of 5 stars4/5
Related podcast episodes
Megakaryocyte maturation involves activation of the IRE1α-dependent adaptive unfolded protein response 0% found this document usefulNuclear Myosin 1 regulates platelet activation and immune response in mice 0% found this document usefulFK506 binding protein 5 regulates cell quiescence-proliferation decision in zebrafish epithelium 0% found this document usefulDynamics and Plasticity of Immune Cells within Tumor Microenvironment 0% found this document usefulInhibition of MLKL impairs abdominal aortic aneurysm development by attenuating smooth muscle cell necroptosis 0% found this document usefulThe Sin3B chromatin modifier restricts cell cycle progression to dictate hematopoietic stem cell differentiation 0% found this document usefulP bodies coat germ granules to promote transgenerational gene silencing in C. elegans 0% found this document usefulIdentifying transcriptomic downstream targets of genes commonly mutated in Hereditary Hemorrhagic Telangiectasia 0% found this document usefulTranscriptional Regulation of the P-bodies Associated Psoriasis Candidate Gene CCHCR1 0% found this document usefulmiR-324 mediates bone homeostasis through the regulation of osteoblast and osteoclast differentiation and activity 0% found this document usefulDNA damage-induced lncRNA MEG9 impacts angiogenesis 0% found this document usefulSingle-cell mRNA-regulation analysis reveals cell type-specific mechanisms of type 2 diabetes 0% found this document usefulHistone variant H2B.Z acetylation is necessary for maintenance of Toxoplasma gondii biological fitness 0% found this document usefulMitochondrial defects leading to arrested spermatogenesis and ferroptosis in a mouse model of Leigh Syndrome 0% found this document usefulRedefining hematopoietic progenitors cells and reaffirming lineage commitment by transcriptional atlas 0% found this document usefulBiopharma Regulatory Requirements with bluebird bio's Scott Cleve 0% found this document usefulDissecting the cell of origin of aberrant SALL4 expression in myelodysplastic syndrome 0% found this document usefulMerTK mediates the immunologically silent uptake of alpha-synuclein fibrils by human microglia 0% found this document usefulTomatoes, Lycopene & Cancer: The Juicy Research on this Pantry Essential 0% found this document usefulIdentifying human islet microRNAs associated with donor sex, age and body mass index 0% found this document usefulEssential role of the CCL2-CCR2 axis in Mayaro virus-induced disease 0% found this document usefulDifferential roles of CTP synthetases CTPS1 and CTPS2 in cell proliferation 0% found this document useful
Related articles
Could Squishy Cells Improve Bone Marrow Transplants? FuturityArticle
Could Squishy Cells Improve Bone Marrow Transplants?
Mar 28, 2019
2 min readA Mutation That Resists HIV Has Other Harmful Consequences The AtlanticArticle
A Mutation That Resists HIV Has Other Harmful Consequences
Jun 3, 2019
3 min readThe Disappearing Y Chromosome The AtlanticArticle
The Disappearing Y Chromosome
Dec 6, 2019
3 min readThrombotic Thrombocytopenic Purpura (TTP) – a Rare Presentation with COVID-19 Aster Medical Journal (AMJ)Article
Thrombotic Thrombocytopenic Purpura (TTP) – a Rare Presentation with COVID-19
Sep 1, 2022
1 Department of General Medicine, Aster MIMS Hospital, Kozhikode, Kerala, India 2 Department of Nephrology, Aster MIMS Hospital, Kozhikode, Kerala, India Dr. Jabir M P, Consultant, Department of General Medicine, Aster MIMS, Kozhikode-673016 Email: j
5 min readIn A CRISPR First, Therapy Intended To Cure HIV Patient Appears Safe — Though Ineffective STATArticle
In A CRISPR First, Therapy Intended To Cure HIV Patient Appears Safe — Though Ineffective
Sep 11, 2019
5 min readOne Protein Eases Problems When Cancer Cells Divide FuturityArticle
One Protein Eases Problems When Cancer Cells Divide
May 12, 2020
2 min readTrump Tweeted About a Dying Boy. Here’s What You Need to Know About His Rare Disease STATArticle
Trump Tweeted About a Dying Boy. Here’s What You Need to Know About His Rare Disease
Jul 3, 2017
3 min readCystic Fibrosis Drugs May Hold Key To Other Diseases FuturityArticle
Cystic Fibrosis Drugs May Hold Key To Other Diseases
Jan 25, 2022
2 min readHow a ‘Stuck’ Genetic Switch Makes Leukemia Worse FuturityArticle
How a ‘Stuck’ Genetic Switch Makes Leukemia Worse
May 23, 2017
Researchers have found new ways to block a protein responsible for halting the production of red and white blood cells in leukemia patients, potentially making way for new treatments for the deadly cancer. In a particularly aggressive form of leukemi
3 min readIn Rare Case, Patient Developed Resistance To CAR-T After Cancer Cell Began Hiding In ‘Plain Sight’ STATArticle
In Rare Case, Patient Developed Resistance To CAR-T After Cancer Cell Began Hiding In ‘Plain Sight’
Oct 1, 2018
In a rare case, a patient developed resistance to CAR-T therapy after his cancer cell began hiding in "plain sight."
3 min readEarly Trauma Leads To Changes In The Blood FuturityArticle
Early Trauma Leads To Changes In The Blood
Oct 21, 2020
3 min readAging Is a Communication Breakdown NautilusArticle
Aging Is a Communication Breakdown
Mar 21, 2019
Johann Wolfgang von Goethe, the 18th-century poet and philosopher, believed life was hardwired with archetypes, or models, which instructed its development. Yet he was fascinated with how life could, at the same time, be so malleable. One day, while
6 min readTests Suggest Potential Therapy For A Childhood Leukemia FuturityArticle
Tests Suggest Potential Therapy For A Childhood Leukemia
Nov 26, 2019
2 min readJust 1 Gene May Be To Blame For This Deadly Leukemia FuturityArticle
Just 1 Gene May Be To Blame For This Deadly Leukemia
Oct 16, 2018
A new study shows how a single gene could be at fault in acute myeloid leukemia (AML), one of the deadliest cancers. Researchers say the breakthrough could eventually lead to gene-targeted therapy that could improve AML survival rates, which have not
2 min readThe Genome in Turmoil: Hope your week went well. It might have changed your genetics. NautilusArticle
The Genome in Turmoil: Hope your week went well. It might have changed your genetics.
Jun 6, 2013
When President Obama delivered a speech at MIT in 2009, he used a common science metaphor: “We have always been about innovation,” he said. “We have always been about discovery. That’s in our DNA.” Deoxyribonucleic acid, the chemical into which our g
6 min readLoxo Oncology Shows High Tumor Response Rates With Second Genetically Targeted Cancer Drug STATArticle
Loxo Oncology Shows High Tumor Response Rates With Second Genetically Targeted Cancer Drug
Jun 2, 2018
Loxo Oncology has earned considerable buzz and a hefty stock market valuation for bringing a genomic-based approach to cancer drug development. The Connecticut biotech’s drugs target highly specific genetic mutations found in cancer cells, regardless
2 min readWith a Rapper’s Death, Harsh Spotlight Falls on Slow Progress Against Sickle Cell STATArticle
With a Rapper’s Death, Harsh Spotlight Falls on Slow Progress Against Sickle Cell
Jun 21, 2017
4 min readCan Parasite ‘Birth Control’ Fight Malaria’s Spread? FuturityArticle
Can Parasite ‘Birth Control’ Fight Malaria’s Spread?
Jan 31, 2019
2 min readCan Cancer Be Treated by Changing Its Cells? NautilusArticle
Can Cancer Be Treated by Changing Its Cells?
Mar 26, 2022
6 min readMicroRNA Snippets May Warn Of Alzheimer’s Down The Road FuturityArticle
MicroRNA Snippets May Warn Of Alzheimer’s Down The Road
Jun 29, 2018
Tiny snippets of genetic material called microRNA may offer a way to detect conditions such as Alzheimer’s disease earlier, according to a new study. Researchers have discovered that changes in microRNA are detectable in mice long before they start t
2 min readJust 1 Missing Atom May Lead To Colon Cancer FuturityArticle
Just 1 Missing Atom May Lead To Colon Cancer
Jun 20, 2018
The development of an aggressive, early-onset form of colon cancer may come down to a single missing iron atom in a key DNA repair protein, according to new research. The findings, which will appear in Nature Chemistry, reveal how a mutation in the M
2 min read‘Silent’ Gene Mutations May Be Harmful, Not Neutral FuturityArticle
‘Silent’ Gene Mutations May Be Harmful, Not Neutral
Jun 10, 2022
2 min readFDA Approves 2 Gene Therapies For Sickle Cell. One Is The First To Use The Editing Tool CRISPR AppleMagazineArticle
FDA Approves 2 Gene Therapies For Sickle Cell. One Is The First To Use The Editing Tool CRISPR
Dec 15, 2023
3 min readFDA Approves 2 Gene Therapies For Sickle Cell. One Is The First To Use The Editing Tool CRISPR TechLife NewsArticle
FDA Approves 2 Gene Therapies For Sickle Cell. One Is The First To Use The Editing Tool CRISPR
Dec 16, 2023
3 min readThis Gene Could Be The Link Between Iron And Prostate Cancer FuturityArticle
This Gene Could Be The Link Between Iron And Prostate Cancer
Jun 1, 2018
New research may explain the link between a high level of iron in the body and prostate cancer. The researchers uncovered the role of the iron storage gene FTH1 and its pseudogenes in regulating iron levels in cells and slowing down prostate cancer g
2 min readThe Science – And Mutations – Behind The Emerging Coronavirus Variants The IndependentArticle
The Science – And Mutations – Behind The Emerging Coronavirus Variants
Jan 15, 2021
Genetic mutation is an evolutionary fact of life. From humans to insects, and from bacteria to viruses, these coding corruptions can pop up anywhere and bring about a series of changes to an organism. Cancer is one of the more better known outcomes o
5 min read3 Drugs Could Reduce Mortality In Patients With Severe COVID FuturityArticle
3 Drugs Could Reduce Mortality In Patients With Severe COVID
Jun 8, 2022
3 min readThese Immune Cells Are Likely Key To Multiple Sclerosis FuturityArticle
These Immune Cells Are Likely Key To Multiple Sclerosis
Jul 23, 2019
2 min readFirst CRISPR Treatment For Blood Diseases Shows Early Benefits In Two Patients STATArticle
First CRISPR Treatment For Blood Diseases Shows Early Benefits In Two Patients
Nov 19, 2019
The first two patients to receive a CRISPR-based treatment for inherited blood disorders have benefited from the experimental therapy, said the companies developing the therapy.
5 min readMap Of Kidney Disease Genes Could Lead To New Treatments FuturityArticle
Map Of Kidney Disease Genes Could Lead To New Treatments
Aug 16, 2021
2 min read
Reviews for Transcription Factors
Rating: 0 out of 5 stars
0 ratings
0 ratings0 reviews
Book preview
Transcription Factors - Katya Ravid
Enjoying the preview?
Page 1 of 1