The Atlantic

T Cells Might Be Our Bodies’ Best Shot Against Omicron

The new variant may undermine some vaccine-derived defenses. But the immune system’s best assassins are likely to hold the line.
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Killer T cells, as their name might imply, are not known for their mercy. When these immunological assassins happen upon a cell that’s been hijacked by a virus, their first instinct is to butcher. The killer T punches holes in the compromised cell and pumps in toxins to destroy it from the inside out. The cell shrinks and collapses; its perforated surface erupts in bubbles and boils, which slough away until little is left but fragmentary mush. The cell dies spectacularly, horrifically—but so, too, do the virus particles inside, and the killer T moves on, eager to murder again.

It’s all a bit ruthless, but the killer T does not care. It is merely adhering to its creed: Virus-infected cells must die so that the rest have a better shot at living. The cold-blooded slaughter can “ between someone having a mild infection and a severe one,” Azza Gadir, an immunologist and scientific advisor at the microbial sciences company Seed Health, told me. And that’s exactly what experts, and offer a safety net that could spare us some of the coronavirus’s worst effects.

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