THE GREAT BATTLE: COVID-2 versus ACE-2

By Ed Rychkun

This single volume containing 6 stories unfolds the great battle between the ACE2 Cell Receptor and his gang of Immune System Good Guys with the COVID-2 Bad Guys gang of invaders. As the microscopic battle escalates to a darker agenda of global depopulation, the epic clash reveals the greater narratives of Dark and Light prophesy.

• Language: English
• Publisher: Lulu.com
• Release date: Jan 31, 2022
• ISBN: 9781678132361

Book preview

Preface

I am going to tell you a fictional story that you will find hard to believe. But that is the beauty of fiction — to stretch your belief system. After all, fiction has been known to become nonfiction.

This story is about the greatest hoax ever perpetrated on humanity. The setting for the story is of course Planet Earth in our present time of 2020. From a greater perspective, this is an important time of prophesy as global consciousness shifts into a new Age of Aquarius that lasts 2160 years in the great Zodiac precession of 25,920 years. This time in our story that has been referred to as End Times has been suggested as being the time chosen to complete the ongoing narrative on Earth in the final epic clash between good and evil forces of consciousness that have dominated civilizations for thousands of years.

Pertinent to our story is a fundamental process of design in living things in that the energetic expression operates in a collective consciousness to create its reality… sort of like a hive mind creating its environment. Of particular interest in our story, and this setting, is that the great hoax changed civilization to a degree of epic proportions. The story I will tell you about stems from a very small set of key players who influence this expression of reality. In our story, we unfold how a very tiny group of human and nonhuman players were effective in creating a destructive global reality by manipulation of a central group of microscopic players.

Without question most humans are deeply aware of good and evil, and how historically what is perceived as Light and Dark have jockeyed for dominion over individual and group consciousness. So yes, this is a story that is centered on this process of Light and Dark consciousness being expressed into reality. Our kernel of good and bad characters are used to show how they infect and affect the greater picture. Now although I have attempted to follow as much historical and scientific truth as possible in presenting these player’s behaviors and their interplay of purposes, the story begins with microscopic characters that dwell in our human bodies called viruses. But for all intents and purposes, this is a fictional account of how these characters that I refer to as the Good, the Bad, the Ugly and the Evil unfold a chronology of events on planet Earth that changed humanity in an epic way forever.

So let me introduce these characters. In our story, it begins in the microscopic living world of human epithelial cells and their enemies called virions. These virions are our Bad Guys. These cells, through their inherently designed processes of insuring human wellness are in a constant battle with trillions of these virions many of whom have deceptive and destructive tactics to survive and to destroy the human host cell they choose to use as their replication vehicles. So here is our first Bad Guy.

As a virion, he operates with other virions through a collective knowing of RNA to infect host cells to become a virus. Quite simply he cannot survive long by himself as a virion so he must find a host to live and reproduce his kind. These Bad Guys are at war with our Good Guys that are part of the defense system of the human cells. In our story, our Good Guys exist at different levels of strength depending on the human immune system and just how intrusive the enemy is. Now understand these guys do not always win the battle and a virus when well entrenched can destroy tissues and even kill the human host. But nevertheless, here are the key Good Guy players that are in the battle to begin our story.

So these are our main microscopic Good Guys always on alert to threats and intrusion like viruses and bacteria, ready to seek out and destroy Bad Guys like COVID-2. As the story progresses, you will get to meet other good, bad, even Ugly players that start out good but can also get deceived into foul play like the ACE-2 Gang.

Now, as the story unfolds new players come in that are downright evil. We have met the Ugly ECV-1 who has been deceived to carry and spread cancer but these real Evil guys are purposely designed to do Ugly stuff directly.

Now we also have some human heroes who are dedicated to understanding these Good, Bad, Ugly and Evil players to combat their plans to infect all humans. And they are the ones that come forward to help the Good Guys. Thus, we meet some human characters that are dedicated to stopping the war. As the plot thickens, we see how this simple local battle escalates to a much greater scale of conflict between the Dark and Light, extending into a global meltdown of Armageddon. These are our key players we meet as the Good human Gang dedicated to combating the Ugly, Bad and Evil guys and aiding the Good Guys.

Our story unfolds with a central bad guy character we call COVID-2. He represents a collective mind of a virus that wants to live inside everyone on the planet. As you will come to understand these microscopic little guys changed the planet in ways that were inconceivable. Now they are not characters in the sense like you and I but these guys know what their purpose is; to live, thrive and replicate just like you and me. And they have built-in smarts like RNA to use. So COVID-2 as a virion is always evolving by mutating and fooling cells to take over and reproduce his species. He is very clever at adapting through mutations and being able to ingest mRNA of other virus abilities for his own good.

Although he is really nothing more deadly than a flu or cold, sometimes depending on the health of the host, he can be destructive. He uses a process called a spike protein to deceive the cell receptors (ACE-2) and enter his preferred cell hosts that happen to be epithelial, like those on the nasal, mouth, bronchial and lung surfaces. The group he represents has been given a name of the SARS Covid-19 virus. In this story even though he represents a virus nothing more than a common cold or flu, we call this bad guy COVID-2 a virion particle who has gotten into a particular body to infect the cells of an older guy named George. And because George’s immune system is not in good shape, COVID-2 has found a good home where the Good Guys are not very effective.

Now COVID-2 is not anybody’s fool and he has developed several key methods to deceive cell Receptors like ACE2 into allowing entry by a process called binding of his special spike protein. And with his own RNA, he has learned to evolve better ways to deceive and reprogram DNA to support his purpose. And he does not forget what his function and design are for. Once in, after he has deceived a cell, he has the smarts to reprogram the human DNA inside to do his bidding which is to spread and replicate.

Once he attempts this if he is not successful in deceiving and controlling a cell, the human immune system and human inflammation processes send out reactions and chemicals like warnings to trigger the Good Guys. Of course the body reacts if he is able to enter and infect, like showing the symptoms of the common cold telling humans things are not right. Then the immune system can work at getting rid of this intrusion and forming an antibody against it in case it happens again. This all goes into memory of cell DNA when this happens.

When COVID-2 is successful, it is because the cell’s entry and detection mechanism on the cell surface has been fooled. These are receptors and sensors that also have specific designs and purposes so hence we now encounter the other players, in particular the one who allowed this to happen, namely the ACE2 Cell Receptor, (the Good Guy) who is supposed to protect the cells from this kind of character. And the other good guys that are supposed to help get rid of these intruders and bad guys make up the gang including, a CD8+ Serial Killer T-Cell (CD-8) who waits on command along with CD4 Helper cells (CD-4) and their process of bad guy annihilation through an MHC Class I molecule on cell surfaces (MHC). They are all supposed to deal with these bad guys by getting their gang mobilized, preventing the deception, stopping the intrusions, and presenting an antibody to remember and destroy them.

So this is the initial setting for our story. George is infected and dying. As it turns out there are others like George having difficulties as well. But because of the underlying manipulations following a greater narrative, these characters have been used to create a story unlike anything else on Earth. So I have given these characters names of COVID-2, ACE-2, CD-4 and CD-8 to relate how these characters representing their types of staggering trillions of microscopic particles, have changed everyone’s world. They set the initial scene for the conflict of deception and intrusion that escalates into deception and intrusion of humanity at a greater scale.

Now although I present them as characters who communicate and think, this may be rather inconceivable to believe anything, but understand that they carry DNA and RNA just like you and me but theirs goes beyond anything you have imagined. These viruses and cells can think, sense, and take logical and instinctual actions of survival way beyond what you may believe. It’s simply a natural intelligence of adaptive evolution that is inherent in DNA and RNA.

Now although I have selected a central set of characters, understand that they represent a collective family of billions of others. But they still function as one mind.

As you engage in the ACE-2, the Good Guy and the COVID-2 Bad Guy remember, it is just a fiction. If there is any resemblance to the truth of nonfiction, it is because I have taken the liberty to use both truth and untruth as a basis to the story. But remember truth is very fickle to the believer, for the real truth is that if you repeat a lie enough times, it becomes the truth to your subconscious. Complicate this with the fact that science is most times fiction until it becomes nonfiction, opposite in the time of perception.

We all have a choice of discernment of our truth — or do we? Are we told the truth or is it changed to influence choices towards lies? Certainly, we know the victors create history as we see media paint history.

Much of the information in this series comes from the most current research on the topics, but even that does not make it true. What is important to note is that this research has not yet been accepted as fact so it can be truth or lie. The victors, that appear to be the media kings in this story appear to be writing their version of truth. So it is with science. It may be bought or controlled to serve the agenda under which it was financed.

So although this book and this story falls under a fictional category, you may find it closer to the truth than you care to believe.

So I will spin a yarn for you that may test your imagination as these characters play out their stories of survival and duty. It will certainly give you an opportunity to know them better.

Enjoy.

Ed Rychkun

BOOK ONE:

ACE-2 Meets the COVID-2 Zombie

ACE2 COVID2 Front Cover

The world of ACE-2

ACE-2 lived in an incredible microscopic world of biology inside a man named George. This was a magical world made up of cells. George himself was made of 30 trillion cells and he housed 100 trillion microbes that used him as a host. ACE-2 was one of some 200 families of cells that made George function as a human. And within that about 20 different types of structures created different major functions supporting George’s existence. And all these families of cells had an outer membrane containing a nucleus that was the brain of the whole operation called DNA and RNA. And they all knew their responsibilities to keep George alive and well.

In this world, everybody knew what their job was. And they all went about their duties in a total instinctual way. No one had to tell them what to do and together they formed a collective mind always in touch with each other and always sensing their environments in chemical and energetic ways. Some were able to sense and analyze the outside environment, while others were designed to sense George’s internal environment. But they were always focused on sensing and correcting things for the greater good of George.

Always on the lookout for information to process so as to stay alive and keep George alive, they had uncanny adaptive intelligence that allowed them to do their jobs the best way. They were always on the lookout for foreign things that could damage George or themselves. Always remembering a solution, always developing signals, and always able to access and call on information from the nucleus DNA, they were on call 24/7 to make things better. Although they were always on the lookout to fix things, they were always sensitive to intruders like bacteria and virus; working together to detect, eliminate and remember those that were a threat. And it was their duty to seek out solutions if one was not at hand.

So although they had a collective mind to keep them all informed as to the activities and responsibilities, they also had access to the central repository of the greater mind of DNA. They communicated by simply knowing and sending signals or creating proteins or molecule like exosomes to deal with problems. They could read and analyze all sorts of information and read frequencies, and biology and know what to do. And they were highly adaptive like when a virus or bacteria threatened, they would summon programs from DNA or send signals to get help from the immune system to detect the threat and create a means of protection. And of course, there were many ways that cells had to help their purposes.

Because they were one mind of the collective, the greater mind was always available, but most of the time, they were only concerned with their own area of responsibility that they expressed like instinct. Everybody was there to express their function in some way.

Within this world, cells lived a certain period of time as they could replicate themselves. This would vary from family to family anywhere from days to months. And they could die of natural causes or be killed. In George, as with humans, cell replication was 1 million per second. In so doing, they would create an identical version of themselves and each would inherit that which it had learned and each automatically knew their responsibilities since they continued to house the central DNA. 

The different types of cells in George’s body had different, specialized jobs to do. The specialization and shape of cells depended almost always on the areas of responsibility. For example, cells that lined the intestine had extended cell membranes. This increased the amount of surface area that was available to absorb George’s food. Nerve cells could be very long, which made them efficient in sending signals from the brain to the rest of his body. Cells in his heart muscle processed a lot of energy, so they had a large number of mitochondrion, the part of the cells where energy is made.

Like all living things, George’s cells would die. The number of cells that he could lose per minute was roughly 100 million. Fortunately, in that same minute, about the same amount would divide, replacing those that died. Just as George would shed dead skin cells, dead cells from internal organs pass through and out of the body with waste products. The length of a cell’s life could vary. For example, his white blood cells lived for about thirteen days, cells in the top layer of his skin lived about 30 days, red blood cells lived for about 120 days, and liver cells lived about 18 months.

In order to protect the nucleus each cell had a 3-part membrane that contained it. So not just anyone could get inside to create damage or interfere with its natural design. To be able to control this, sense and allow the right messages to get into the cell, a channel called a receptor-effector was like a doorway through the cell wall. On the outside the receptor of which there were many types numbered in the 10-20,000 on any cell and these would sense the information or threat, then send a signal through to effect a response.

All cells have a membrane. Cell membranes are the outer layers that hold the cell together. They let nutrients pass into the cell and waste products pass out. Not everything can pass through a cell membrane. What gets through and what doesn’t depends on both the size of the particle trying to get in and the size of the opening in the membrane.

Cells also have a nucleus. This is the cell’s control center. Cells continually divide to make more cells for growth and repair in the body. The nucleus contains the information that allows cells to reproduce or make more cells. Another important part of a cell is the mitochondrion. This is the part of the cell where food and oxygen combine to make energy.

On the surface of George’s cells were receptors and many sensing devices. Sometimes their response would be to send a signal to DNA to fix a problem in their area. Sometimes it would be to send cargo or messages through exosomes or launch antibodies or even T-cells or something to address the issue to protect, repair or even destroy something. And of course the receptor being highly adaptive would store the information for the good of the collective, and the DNA.

Typically there are channels linked, protein and enzyme receptors. 

ACE-2 was an enzyme receptor and he lived on the surface of a cell in George’s lung. This was his nickname as it stood for a big long name angiotensin-converting enzyme or ACE. It was a pretty big family that lived on special surface cells in his lungs to detect and protect and fix things but it also included other areas of George’s body like the respiratory tract, heart, eyes, and sinus passages.

Of course like all the other enzymes he was referred to as a protein that was born to help reactions without becoming altered, like the way fuel burns when it's used.

ACE-2 had a buddy TRANS-2 who also had a big long fancy name as TMPRSS2 for transmembrane protease serine 2. Like ACE-2 he was part of the cell family scattered throughout the body including the heart, bladder, pancreas, kidney, and nose. There were even some in the eyes and brain.

As cell receptors, both ACE-2 and TRANS-2 worked with thousands of others like them on the cell surfaces. These cells that were their homes were called endothelial cells scattered across the respiratory and digestive tracts. Both ACE-2 and TRANS-2 were able to express their duties in nasal, bronchial, and gastrointestinal areas but although they were localized in the lung surface of George, they always knew what was going on in the rest of the collective.

However, both TRANS-2 and ACE-2 had only come on the scene as the cell they lived on had been killed by a virus, and effectively they were reborn on a new cell they could live and function for up to 17 months.

Because they carried their own design attentive to the cell’s DNA, both got into their jobs right away.

Sometimes they would communicate in their own telepathic way. Of course they did not have eyes like humans, but they had many sensory skills to always be aware of the world around them.

But as these two had just been born a week hence, as they began to recall what had happened to their previous cell host, there was a very disturbing sense of a threat that came into their awareness.

Receptor-Effectors we are

It was in this renewal that TRANS-2 and ACE-2 began to discuss their world. They knew that they were part of the brains of the operation of cells. They, like millions of others worked as a collective on a membrane which controls the mechanisms by which the body translates environmental signals to behavior.

Through this process cells had intelligent behavior to recognize toxins, proteins, and employ escape maneuvers even when these were outside the body. It all worked through these integral member proteins that were part of the membranes’ internal surface to assist them in their jobs.

ACE-2 was like a doorway on the cell surface as one of two types of receptor proteins operating like nano antennas tuned to respond to environmental signals. They were inactive and active, shape shifting back and forth as the electrical signal charges altered. This responded to environmental impulses, charges as from physical stimuli like in a foreign influence.

He was a shape shifting receptor that provided the cell’s basic awareness. He was the point of activation of the effector cells on the inside of the cell membrane that could effect directives, depending on the way a molecule on the outside would bind to the cell walls and his or other receptors.

Once he allowed the signal inside, the effector protein engaged the appropriate response. So he was like one of many information pathways called signal transduction gateways that opened or closed like transistors depending on electrical charges. He was not alone, for every cell had thousands of these channels.

Of course ACE-2 knew exactly how to express his responsibility and transmit communications. He was like a lock and key system. He had the key to unlocking the lock on a special revolving channel which connected to the inside of the cell. Every time the channel revolved, it opened to allow 3 positive atoms (ATPase, sodium, potassium) to go out and admit two positive potassium atoms into the cytoplasm. This happened at hundreds of cycles per second. Inside the cell it gets a more negative charge while the outside gets positive. Negative charge below the membrane was called membrane potential. The lipid part does not let charges across its barrier, so the internal charge stays negative. This positive out and negative in was like a self charging battery whose energy was used to empower biological processes. Given the right potential, it then sends the appropriate signal to act. Of course ACE-2 new exactly how this worked.

On ACE-2’s cell membrane it had hundreds of thousands of switches like these and thus the behavior triggered by the effector response was through all these switches at one time responding to the right electrical potentials. They just knew how to act as one.

Like the rest of the multicellular communities of 50 trillion cells, ACE-2 cells had a division of labor in tissues and organs for specific functions and when a unified effector response was required it is up to the brain to coordinate the required execution of the programs residing in the repository of DNA.

Thus ACE-2 as a guardian and sensing device, did not have the final say on the response from the nucleus and DNA, although it was the repository of responses and DNA blueprints that encode the production of proteins. And even though a cell and nucleus could die, a replacement cell still carried the memory onto its replication. It was all contained with the collective so any new cell automatically contained the collective DNA and memory.

Thus all the environmental stimuli of ACE-2’s old cell had created cell intelligence individually but also for awareness in the receptors of all, remembering what action was taken through the effector.

Thus ACE-2 was programmable from outside the cell. Data was entered into the cell via the membrane receptors on the surface through the lock and key gateway that would bind to or receive information that triggered effector proteins on the inside. That then actioned cell appropriate effector proteins. These then convert environmental information into the behavioral language of biology.

When the signals that were accepted from the environmental stimuli became acceptable to the ACE-2 receptor, he could trigger the effectors to have the brain haul out the DNA program from the nucleus to reload and run so as to create the organ/tissue the way it was supposed to function according to the blueprint. Or if an immune response was required, it was handled by the brain.

So ACE-2 knew that once receptors allowed it, the effectors would send and receive chemical messages constantly to coordinate the actions of distant organs, tissues, and cells. The ability to send messages quickly and efficiently enabled cells to coordinate and fine-tune their functions.

With ACE-2 his geographic area was the lungs covered by a single base station in a cellular network. Growth and development in the lung required that his host cells communicate with each other and react to signals that came from other parts of the body. The binding of a hormone to its receptor initiated a series of molecular transformations, called signal transduction, that relayed the growth signal through the cell.

There were four categories of chemical signalling available: paracrine signalling, endocrine signalling, autocrine signalling, and direct signalling across gap junctions. Cell communication was the process by which a cell detected and responded to signals in its environment. It was up to the cells receptors to perceive changes in nutrient availability and adapt their metabolism as needed. And there were always exosomes moving around to them all as communication and cargo carrying molecule.

This was a large responsibility for ACE-2. But there were other important responsibilities as it related to a new player on the block COVID-2.

A serious job they had

Now although ACE-2 and TRANS-2 were separate, they were clones of millions of their kind functioning under a collective family of cells, receptors and mind. Yet as the collective, they were each unique and could function and learn on behalf of the collective.

It wasn’t that ACE-2 was new to the game. He was functional instantly upon the birth of his host cell but he was aware that his previous host cell had died after 6 months, not after the normal life span of 17 months. As their cell hosts died, they were of course replaced with new surface population of ACE-2’s on the cell membrane where he lived with millions of other ACE-2 clones. They all guarded the nucleus where he acted as the gateway to the inside. There, the cell nucleus held complete code of life in DNA. As such he upon being born automatically was part of the collective consciousness mind and retained all that he had retained before.

Of course he knew that as an enzyme and receptor he had a job to do. One of these was to help make or speed up specific chemical reactions. It made things happen converting a specific set of reactants into specific products. He knew that without enzymes like him, life would not exist, so it was pretty important.

As a gateway to protection, he was also important because if he felt or sensed a threat, it was his duty to send a signal to others and to warn that a potential solution from DNA was needed for the brain and the collective to act upon. He would affect this through his effector to be part of the solution to a problem. He could send a signal to get many things going; like the immune system.

But the very idea of this gave ACE-2 a chill. There was something he was not grasping about his previous cell life. And it had to do with a previous important function.

This very important function was in his physical area of operation and his responsibilities related to his family of special cells.

ACE-2 was part of the angiotensin converting enzyme family. In George’s body, it caused vasoconstriction and increase in blood pressure and also promoted sodium retention in the kidneys. His responsibility included him secreting a protein that created a separation into different types of angiotensin, called Ang I, and angiotensin II into the vasodilator angiotensin. A very important job was to balance this process in collaboration with ACE-1 who was his Buddy. The main job of ACE-2 was the balance of blood pressure and inflammation in George.

This was a pretty tricky business especially in George because there was always a delicate balance due to his poor health. The way they did that was to control Ang I receptors that regulated blood pressure and balancing it with opposing actions of Ang II. 

Thus, ACE-2 had to play a crucial role in the receptor effector pathway signal process because it opposed the actions of Ang II. Normally it was a beneficial role in many diseases such as hypertension, diabetes, and cardiovascular disease where its expression is decreased. But Ang II drives lung injury. If there is a decrease in ACE-2’s activity then it can’t break down the Ang II protein, which means there is more of it to cause inflammation and damage in the body.

So a virus that impacts other tissues could express ACE-2 actions in a negative way like in the heart, where damage and inflammation could occur. The kidneys, liver and digestive tract could also be injured and blood vessels could also be a site for damage if ACE-2 was not performing his duties properly.

This control axis through the membrane formed by ACE-2 represented an endogenous counter-regulatory pathway within it and its actions are opposite to those of the ACE axis. So managing this balance played key role of ACE and ACE-2 in the inflammatory and blood pressure processes in conditions such as cardiac hypertrophy, pulmonary hypertension, glomerulonephritis, lung injury, sepsis, and acute pancreatitis, most of which were George’s problems.

It made it very difficult for ACE-2 for when you block the actions of ACE-1 but not ACE-2, because ACE-2 drove the production of Ang II the effect was that ACE-1 and ACE-2 having a yin-yang relationship came into conflict. ACE-1 increases the amount of Ang-II, whereas ACE-2 reduces Ang-II levels and its ability to increase blood pressure and tissue injury.

To further complicate this, ACE inhibitors were commonly prescribed for patients with hypertension, heart failure and kidney disease which was the problem with George. Between blood pressure, inflammation and the ACE blockers it was becoming a difficult chore for ACE-1 and ACE-2 to maintain balance.

Another buddy to ACE-2 was TRANS-2 scattered throughout the body and on the same cell as ACE-2 lived on. His family was also in the heart, bladder, pancreas, kidney, and nose. There were even some of his family in the eye and brain. In technical terms, he was Transmembrane serine protease 2 (TMPRSS2), a cell surface protein primarily resident on endothelial cells across the respiratory and digestive tracts. As a serine protease, he was involved in the cleaving peptide bonds of proteins that have serine as the nucleophilic amino acid within the active site. Both the ACE2 and TRANS2 families were in the lung, nasal, bronchial, and gastrointestinal epithelium cells.

So these guys had some very important jobs as receptor effectors controllers through the signaling pathways that acted like homeostatic regulators of vascular function. They controlled systemic actions including the regulation of blood pressure, natriuresis, and blood volume control. They also played an important local role, regulating regional blood flow and controlling trophic responses to a range of stimuli.

But ACE-2 had many other duties as a resident on epithelial cells of the lung. As the interface between the environment and the organism he also served important functions including barrier protection, fluid balance, clearance of particulate, initiation of immune responses, mucus and surfactant production, and repair following injury.

The epithelial cell types of the lung were varied and numerous. Together they provided structural integrity, as a physical barrier against environmental insults, allowed gas exchange, enhanced ion and fluid transport, secreted growth factors, chemo attractants, antimicrobials, and expressed adhesion receptors, oxidant species, and lipid mediators for neighboring cell communication and matrix attachment. It was a big job.

So, he was in a world on the surface of George’s lungs in these epithelial lung cells. He knew his family was part of work to do in the heart, gut, lungs, and inside the nose. They were a key cog in a biochemical pathway that regulated blood pressure, wound healing, and inflammation.

ACE-2 had a pretty important job that was to act as a receptor like a guard of a gateway into the cell he was assigned to. He had a job to watch out for bad things like viruses and let them into the cell or not. So he felt pretty proud of that guard like responsibility.

There were many of his family as a protein on the surface of many cell types. As an enzyme he would generate small proteins – by cutting up the larger protein angiotensinogen – that then go on to regulate functions in the cell.

Although he was an individual, his family was present in many cell types and tissues including the lungs surface, heart, blood vessels, kidneys, liver and gastrointestinal tract and in the sinus passages of the nose, he was still part of a collective mind where everyone knew their place and function.

And he was on the epithelial cells which line certain tissues and create protective barriers for the exchange of oxygen and carbon dioxide between the lungs and blood vessels as it occurs in the lining in the lung. But he was still aware of things in other areas like the nose, mouth and lungs. In the lungs, ACE-2’s family was highly abundant on type 2 pneumocytes, an important cell type present in chambers within the lung called alveoli, where oxygen is absorbed and waste carbon dioxide is released.

So ACE-2 was an important guy in a biochemical pathway that is critical to regulating processes such as blood pressure, wound healing, oxygen transfer, and inflammation.

Of course, he worked with other families of enzymes in his work area of the mouth and nose. Some worked in the mouth to help break down large starch molecules into smaller sugar molecules. He knew there were approximately 1300 different enzymes found in the human cell.

But as the reborn ACE-2, he re-assimilated himself on this new cell and re-established himself, and he knew something was not right with him and ACE-1. When he began to look at the situation where he was, George was suffering from inflammation and lack of oxygen, his blood pressure was high, and it was working against the ACE-1 ACE-2 balancing act. It was all causing more serious problems for the two of them trying to deal with pressure, inflammation and in a family that was not providing oxygen transfer.

So, it seemed that their balancing was becoming a disaster. And he was beginning to pick up from the collective that his family of cells were losing connection to the collective. Were they all dying like he did with his previous host cell? What was going on?

His intuition was telling him something was very wrong.

George has a problem

George was getting very sick and was in the hospital having serious respiratory problems. ACE-2 had noticed that his job of dealing with inflammation and high blood pressure was getting tougher and tougher and the cell family seemed to be losing touch, not functioning in their responsibilities. His own cell host had died in 6 months and not lived the usual 17 months.

What they did not realize was that George had been invaded by a virus. He had picked up an infection. He had shaken hands with a friend and then touched his mouth and eyes to allow a virion in. In addition, he was close to his friend who had sneezed. He had inhaled what the medical community was saying was a new strain of virus they named SARS-Covid-19 that they said was indicated by a sample of genetic material found in George’s lung. It had bound to his family of surface cells in the nasal cavity and started replicating working its way down the respiratory tract to the lungs.

How did that happen? It seemed ACE-2 and his family should have been the main receptors to detect this invasion. Unbeknown to them was they had been fooled by a very smart cold-flu virus and could not do their job. He did not realize that this clever virus had been working its way from the nasal cavity down through George’s respiratory tract into the lungs. ACE-2’s own host cell down the line in the lungs had died as a result.

George’s ciliated cells were the primary host in the nose and were infected allowing the conducting airways to be infected with this new virus. Even though there was local infection of the virus there was a limited immune response except to produce the usual cold-flu symptoms.

Similarly, when George’s upper airway and conducting airway became infected, the immune response seemed to be compromised in response. Even when the virus had propagated down the respiratory tract along the conducting airways into the lungs a more robust innate immune response did not happen. The symptoms were there but the antiviral remedy wasn’t, and it was worsening.

It was a process of this smart virus named Covid-19 that was replicating unnoticed. By this time these Covid viruses were well entrenched. So given George’s age of 60, his immune response system was not in the best shape to handle this invasion. He was now having difficulty breathing.

Unfortunately, George had progressed to develop a serious problem where the gas exchange units of the lung had infected alveolar type II cells. The virus had moved into type II cells preferred over I cells. They could now propagate within type II cells where large numbers of viral particles could be released, and the cells would undergo apoptosis and die. That is what happened to ACE-2’s host.

George’s doctor was explaining the situation to his wife Ethyl.

Ethyl, he said, the viral infection process is now well underway as it was able to create a self-replicating pulmonary toxin to release viral particles infecting type II cells in adjacent units. The result is diffuse alveolar damage to George’s lungs.

At this point, he continued, this wound process has led to more severe scarring and fibrosis. Recovery would require a vigorous innate and acquired immune response and epithelial regeneration but it isn’t happening fast enough. George is now at a serious risk stage because of his diminished immune response and reduced ability to repair the damaged epithelium cells. George also has reduced mucociliary clearance, and this may allow the virus to spread faster,

What is that? asked Ethyl.

It is the gas exchange and filtering units of the lung more readily assisting the process.

Why could this not be seen earlier?

What George has done was to contact a virion. This particular virion was an airborne virus that had been airborne by another human and we can say now it is a COVID-19 virus. It is smart and we have not seen this type so there is no cure or antibody yet. It looks like a simple cold in the beginning and it seems to fool the immune system until it is established as it then takes the character of flu and influenza if not arrested. Once it is well established it can create bigger issues like George is having and pneumonia can develop. As you know, a common cold simply takes its course in a few weeks without complications and goes away.

But because George is diabetic and has blood pressure problems as well as breathing issues, he is more vulnerable.

As is anyone that gets a severe cold or the flu. His compromised immune system does not help. Our problem is we know little about this strain of cold like virus that seems to very, very adaptive and smart.

What do we do?

Watch and put him on life support if necessary, hoping his heart and organs don’t fail, said Dr Brown.

I have no clue what this virus is but the big experts are telling us this is a highly potent infection virus that belonged to the SARS COVID 19 virus because of its similarity. It is the one that is infecting the planet.

George had unknowingly contacted several virions through his nose and mouth and it had rapidly assimilated itself over a short period of two weeks.

And because George was 60, having led a rather volatile life of stress and conflict, his immune system was not performing. With added heart and circulatory issues and many respiratory problems, George was a key target for the virus to create chaos and complicate his health issues even further.

George had been infected by a new virus under the direction of the bad guy COVID-2 who had planned an attack of his family of virions only 2 weeks prior.

Meet COVID-2 the Zombie

COVID-2 and his gang of zombie virions had invaded a human friend of George. Again as a collective part of the Covid-19 virus, he was outlying a plan to find a new host and implement new strategies from what they had learned.

Under this plan they would become mobile and airborne from the current host, looking for a new victim to infect.

COVID-2 was a virion, deemed by the experts as part of the SARS COVID-19 virus family. He was a complete virus particle consisting of a DNA and RNA core with a protein coat to attach to cells. He was part of a family of viruses that numbered so many they could stretch across the galaxy. They were like nanotechnology, tiny on a molecular nanometer scale, equipped to invade the cells of other organisms and hijack them to reproduce themselves.

Like other viruses the COVID-2 family relied on the cells of other organisms to survive and reproduce, because they can’t capture or store energy themselves. So they have become very clever at finding hosts not able to function outside a host organism.

COVID-2 although part of the collective was an independent virion especially effective in shouting at the collective to undertake their purpose. He, much like ACE-2 was different in that he liked to take the lead and learn to adapt and adjust survival skills rapidly. Of course the collective benefited from his leadership.

He was briefing his family on what they had learned from George’s friend they had infected. He sent a signal shock into the collective.

Ok, you Guys, listen up, he said, when we are outside a cell, we wrap up into an independent particle as a virion. We can survive in the environment for a certain period of time, which means we remain structurally intact and capable of infecting a suitable organism if one comes into contact.

When you attach to a suitable host cell – this depends on the protein molecules on the surfaces of the spike protein and the cell – you need to be able to penetrate the cell. Once inside, you hijack the cell to produce more virions. Then you can deploy their machinery to create more virions to make their way out of the cell, usually taking control or destroying it in the process, and then head off to infect more cells.

At the core of a virus particle is the genome, the long molecule made of DNA or RNA that contains the genetic instructions for reproducing us. This is wrapped up in a coat made of protein molecules called a capsid, which protects our genetic material. When you hijack it you can use your own RNA DNA to provide the instructions to the cell.

So COVID-2 and his family were like predators with a specific prey they could recognize and attack. He could mutate and combine with another virus which means he can switch species.

I want you all to understand that we as a collective are in the air and on various surfaces only for so long and it is imperative that you find a home as quickly as possible. We rely on a short life span of a few hours to a few days depending on the surface before we can find a host. That home in the human is a receptor called ACE-2 and is the entry point in his nose and mouth where these surface cells are prevalent.

Remember we are very intelligent and can think and adapt. We do things that they do not expect. We adapt to the environment and can change by way of rapid mutation in order to survive.  But you must act fast as we depend on other living things to reproduce.

But how can we get through when these cells have receptors that can detect us and create antitoxins or kill us?

Ok here is the secret, when you get in to find these cells their body becomes a reservoir for virus particles which can be released in bodily fluids – such as by coughing and sneezing – or by shedding skin or in some cases even touching surfaces. Once you highjack the cell you can release virions into their blood and fluids.

We have to execute several steps effectively. First, we need to get in through the nose or mouth to find host cells. Then we need to fool them so we get inside. Then we work our way down through the respiratory tract to the lungs that is our preferred home. We fool them into allowing us inside and screwing up their normal functions so we are undetected until too late. The best that they can do is make us look like a common cold and there is no cure for that. Once we get into the center, we execute new strategies to infect other cells. Got it?

Ok, how do we get in?

Humans hold a key that allows them to unlock normal molecules called viral receptors on a human cell surface. We get the key and slip inside.

We all have a spike (S) glycoprotein that can bind to the cell membrane protein angiotensin-converting enzyme 2 (ACE2) to enter human cells.

These guys are pretty stupid and when you grab on to bind to ACE2 via the S protein on its surface we can have our S protein cleave into subunits, S1 and S2. S1 contains the receptor binding domain which allows us to directly bind to the peptidase domain (PD) of ACE2.

I don’t get it?

Of greatest relevance to our entry is Ang II that can increase inflammation and the death of cells in the alveoli of their lungs which are critical for bringing oxygen into the body. These harmful effects of Ang II are supposed to be reduced by ACE2.

So when we bind to ACE2, it prevents them from performing normal functions to regulate Ang II signaling. Thus, ACE2 action is inhibited, removing the brakes from Ang II signaling and making more Ang II available to injure tissues. This is like decreased breaking contributing to injury, especially to the lungs and heart.

That makes them confused working in our favor. And when the amount of their family is reduced because we are occupying the receptors, individuals may be more susceptible to severe illness but best of all their focus is confused while we move in and take over the cell.

So it is a good diversion? That is because enough ACE2 is available to facilitate our entry but the decrease in available ACE2 contributes to more Ang II-mediated injury. So reducing ACE2 will increase susceptibility to inflammation, cell death and organ failure, especially in the heart and the lungs?

Exactly. The lungs are the primary site of injury by infection, which gives us a chance to really get going. So we need to get there fast.

The key is inflamation. Ang II drives lung injury. If there is a decrease in ACE2 activity (because the virus is binding to it), then ACE2 can’t break down the ANG II protein, which means there is more of it to cause inflammation and damage in the body.

But we also can impact other tissues that express ACE2, including the heart, where damage and inflammation can occur. The kidneys, liver and digestive tract can also be injured. Blood vessels may also be a site for damage.

Angiotensin converting enzyme (ACE, aka ACE1) is another protein, also found in tissues such as the lung and heart, where ACE2 is present. Drugs that inhibit the actions of ACE1 are called ACE inhibitors. Examples of these drugs are ramipril, lisinopril, and enalapril. These drugs block the actions of ACE1 but not ACE2 and they could be present to help the confusion. ACE1 drives the production of Ang II. In effect, ACE1 and ACE2 have a yin-yang relationship; ACE1 increases the amount of Ang II, whereas ACE2 reduces Ang II.

By inhibiting ACE1, ACE inhibitors reduce the levels of Ang II and its ability to increase blood pressure and tissue injury. ACE inhibitors are commonly prescribed for patients with hypertension, heart failure and kidney disease. So these are good for helping our plan.

You want to get through the conducting airways to the lung cells to the gas exchange units into the lung as fast as possible.

There is another gateway called TMPRSS2 activates; or primes entry. Our spike protein which allows us to fuse to the respiratory cell surface through binding it primes the spike-domain (S) by cleaving as the S1/S2 sites. These guys are also pretty stupid.

But how do we avoid detection as a threat?

Look these guys have millions of bacteria and viruses wandering around that they coexist with, some are even beneficial, some are harmless, others have created antibodies too. We look like a harmless common cold, they don’t know we go beyond that. We are modified so we are not on their immune radar. We just need a two-fold process, first to confuse them then look harmless as we sneak in the back door.

We can latch onto the ACE2 receptors undetected like it was ok to do. This is partly to do with our animal origins and we look pretty and harmless because we are common among animals, and in humans cause illnesses similar to the common cold, which are usually not severe. But remember we are zoonotic, meaning we have the ability to jump between animals and humans. That gives us another edge in that these humans don’t think viruses like us can hurt humans so they don’t really have a list of our type of virus in their inventory.

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