NPR

Mouse Hunt: Lab Races To Grow Mice For COVID-19 Research

Coronavirus researchers need the right genetically engineered mice to test potential vaccines. But most of these mice have been on ice. One lab is breeding a new generation of mice to meet the demand.
Cat Lutz (far left) in her lab at the Jackson Laboratory Mouse Repository.

Laboratories across the world are gearing up to develop vaccines that can stop the spread of the deadly coronavirus. They've got the funding; they've got the talent. But they don't have the mice. In order to test and ensure that vaccines are safe and effective, researchers typically conduct experiments on animals, usually mice. Though some labs are experimenting with ferrets and monkeys for this virus, mice But researchers can't use ordinary mice. That's because the coronavirus doesn't make mice sick. Humans have to genetically engineer them to be susceptible to the virus. But it seems there are no such mice to be found. The problem is that the genetically altered mice that researchers need have been on ice for the past few years, says Cat Lutz, senior director of the Jackson Laboratory Mouse Repository in Bar Harbor, Maine.

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