Lives in Chemistry – Lebenswerke in der Chemie Series
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About this series
LARRY E. OVERMAN, born in 1943 in Chicago, had joined the newly founded Faculty of Chemistry, University of California, Irvine in 1971. It became his homebase for more than 50 years until his retirement as Distinguished Professor of Chemistry, Emeritus.
How come that he and his wife had chosen Irvine? That over 300 graduate students and postdocs have chosen his lab? That he served also as Chair of the Chemistry Section of the US National Academy of Science, as a founder and consultant in the pharmaceutical industry? Who were his mentors, his professional friends? Why did he early on chase “new chemical reactivity” after his first unexpected discovery? Which of his natural product total syntheses are textbook knowledge today? Who of his students became leaders, even a Nobel Laureate? Larry provides answers.
He managed challenges with impressive rigor and elegance. His students praise him and his unique “Let’s see what happens” and “research is a group endeavor” approach!
l-i-c.org
Titles in the series (3)
- Leben mit Licht und Farbe: Ein biochemisches Gespräch
4
Dieter Oesterhelt (*1940) und Mathias Grote (*1978) trennt eine Generation, die Biochemie hat sie ins Gespräch gebracht. 1970 stieß der Nachwuchsforscher Dieter Oesterhelt auf einen Farbumschlag von Purpur nach Gelb, und den wollte er verstehen! Wie schon als Kind machte er sich auf seinen eigenen Weg gemäß dem Prinzip: Nichts lesen oder lernen, sondern etwas selbst erfahren was noch niemand sonst wusste. In der Folge entdeckte er die molekulare Pumpe Bakteriorhodopsin und damit eine neue Art Photosynthese. Offenheit für innovative Methoden, interdisziplinäres Arbeiten und weltweite Kooperationen machten seine Gruppe am Martinsrieder Max-Planck-Institut für Biochemie zu einem Hotspot der molekularen Lebenswissenschaften. Die Gespräche der beiden im Münchner Wohnhaus von Dieter Oesterhelt geben tiefe Einblicke in das Wesen moderner Forschung. l-i-c.org
- NMR – Mein Kompass in der Organischen und Medizinischen Chemie
8
Immer wenn er meinte, sein Forschungsgebiet verstanden zu haben, suchte er nach einer neuen Arbeitsrichtung. Er machte sich so, entgegen manchem Rat, einen großen Namen in der NMR-Spektroskopie sowie in der Bioorganischen und Medizinischen Chemie. Horst Kessler (*1940), einst sehr guter Sportschwimmer, zog seine „Bahn in der Chemie“ von Suhl über Leipzig nach Tübingen, Frankfurt und schließlich 1989 zur TU München (TUM). Dort leitete er das von ihm gegründete Bayerische NMR-Zentrum, ein Leuchtturm der medizinischen Proteinforschung. Die räumliche Anordnung von Atomen und Atomgruppen und ihre Beweglichkeit aufzuspüren ist sein Metier: erst in kleinen organischen Modellverbindungen, dann in immer größeren, biologisch interessanten Molekülen und Arzneiwirkstoffen. Horst Kesslers große Schule ist international und so vielseitig wie seine Forschung – mit der Anwendung immer im Blick. l-i-c.org
- Designing Synthetic Methods and Natural Products Synthesis
9
LARRY E. OVERMAN, born in 1943 in Chicago, had joined the newly founded Faculty of Chemistry, University of California, Irvine in 1971. It became his homebase for more than 50 years until his retirement as Distinguished Professor of Chemistry, Emeritus. How come that he and his wife had chosen Irvine? That over 300 graduate students and postdocs have chosen his lab? That he served also as Chair of the Chemistry Section of the US National Academy of Science, as a founder and consultant in the pharmaceutical industry? Who were his mentors, his professional friends? Why did he early on chase “new chemical reactivity” after his first unexpected discovery? Which of his natural product total syntheses are textbook knowledge today? Who of his students became leaders, even a Nobel Laureate? Larry provides answers. He managed challenges with impressive rigor and elegance. His students praise him and his unique “Let’s see what happens” and “research is a group endeavor” approach! l-i-c.org
Dieter Oesterhelt
1976–1979 ordentlicher Professor an der Universität Würzburg, seit 1980–2008 Direktor am Max-Planck-Institut für Biochemie, Martinsried.
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