Welcome back! In this episode, we delve into the compelling nexus of artificial intelligence (AI), cryptocurrency, and the future of decentralized applications. Our first guest, Humayun Sheikh, CEO of Fetch.ai, brings a wealth of experience from his early days at DeepMind. We discuss the progression of AI and how it's integrating with blockchain technology, focusing on agent-based systems that improve user interaction and commercial prospects.Later in the show, Chandra Duggirala and George Burke join us. As Bitcoin pioneers and the brains behind Portal DeFi, they discuss how Portal—an Operating System for smart contracts on Bitcoin—bridges to other chains.We also touched on the idea of "crypto as the currency of AI," a concept Humayun illustrates with the ways digital currencies and distributed ledger technologies enable microtransactions and value exchanges between autonomous agents. This model promises more efficient and secure interactions, sidestepping traditional centralized platforms.Moreover, we discuss AI's broader implications across various sectors, such as healthcare, where decentralized agents could manage personal data more securely and efficiently. Humayun emphasizes the critical importance of privacy and user control in the evolving AI landscape.Our conversation also covers the launch of the Artificial Superintelligence Alliance, a collaboration among Fetch.ai, Singularity Network, and Ocean Protocol, aimed at creating a comprehensive technology stack for consumers and developers, providing a decentralized alternative to conventional big tech solutions.Portal is positioning itself as a leader in the crypto space by implementing groundbreaking technologies like multi-party HTLC (Hash Time Lock Contract) and channel factories to revolutionize how transactions are processed on their platform.Show Highlights:00:00:03 - Introduction to Commercial Paradigm Shifts00:00:24 - Welcome to The Charlie Shrem Show00:00:53 - Guest Introduction: Humayun Sheikh00:01:44 - Humayun's Journey in AI and DeepMind00:03:10 - The Evolution of AI Commercialization00:05:45 - The Role of Agents in AI and Software Applications00:07:26 - Crypto as the Currency of AI00:09:51 - Practical Applications of AI Agents00:12:55 - Challenges in Current AI Implementations in Healthcare00:13:20 - Ensuring Data Privacy and Security in AI00:15:11 - Launch of the Artificial Superintelligence Alliance00:22:21 - Discussion on Voting Rights and Residency in Puerto Rico00:23:06 - Introduction to Portal and Bitcoin DeFi00:25:02 - Experiences and Developments in Puerto Rico00:26:08 - Highlights from Token 2049 in Dubai00:27:30 - Backgrounds of Portal Founders00:34:07 - The Future of Bitcoin and Crypto Integration00:37:41 - Technical Explanation of Atomic Swaps00:43:45 - Enhancements in Lightning Network and Portal's Role00:46:28 - Final Thoughts and Future of PortalThanks for tuning in, and don't forget to subscribe for more deep dives into the most exciting developments at the intersection of AI and blockchain.-Charlie Shrem