The Oncology Journal Club - Delivering Oncology News DifferentlyThe Oncology Podcast, part of The Oncology Network, is proud to present Episode 3 in the second series of The Oncology Journal Club Podcast.Dr Kate Clarke explores a clinical conundrum with the latest insights on neo-adjuvant immunotherapy for DMMR, MSI-high GI cancers, discussed with the clarity and depth you've come to expect from our team. For Professor Craig Underhill's main paper segment, Dr. Ashray Gunjur drops by to discuss the microbiome's predictive power in immunotherapy responses, Professor Christopher Jackson delves into the OPRA study's latest findings on chemo-radiotherapy sequencing for rectal cancer, bringing to light the pivotal role of patient-centred discussions.In Quick Bites, the discussion hits home with the three S's—sitting, shitting, and sex—and their profound impact on post-cancer quality of life. Highlighting the importance of comprehensive support systems in these often-overlooked areas, we also dissect the worrying trend of early-onset colorectal cancer and its broader implications. With a review of a study about the duration of immunotherapy in non-small cell lung cancer, this episode promises to fuel ongoing debates on treatment duration and patient outcomes, highlighting our commitment to keeping you at the forefront of oncology discourse.The conversation takes a crucial turn as we tackle the uncomfortable yet necessary topic of presenting unfunded treatment options in oncology, exposing the delicate balance healthcare professionals must maintain in an era marked by scarce resources and rising demands.For papers, bios and other links visit the Show Notes on our website.For the latest oncology news visit www.oncologynews.com.au.We invite healthcare professionals to join The Oncology Network for free - you'll also receive our free weekly publication The Oncology Newsletter.The Oncology Podcast - An Australian Oncology Perspective