Insulin feedback and PI3K inhibition in GBM

FromNeuro-Oncology: The Podcast

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Insulin feedback and PI3K inhibition in GBM

FromNeuro-Oncology: The Podcast

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Length:

25 minutes

Released:

Oct 6, 2023

Format:

Podcast episode

Description

Description: Dr. Maya Graham interviews Dr. Evan Noch about his and his team's recent manuscript entitled: "Insulin feedback is a targetable resistance mechanism of PI3K inhibition in glioblastoma", published online in Neuro-Oncology in July 2023. Read Paper

Released:

Oct 6, 2023

Format:

Podcast episode

Titles in the series (79)

Neuro-Oncology: The Podcast will keep you up to date about the latest advances in the field as we present conversations with the authors of selected papers from Neuro-Oncology and its sister journals, Neuro-Oncology Practice and Neuro-Oncology Advances.

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Announcing Neuro-Oncology: The Podcast: Announcing Neuro-Oncology: The Podcast by Neuro-Oncology: The Podcast
1 min listen
Vorinostat and bevacizumab for recurrent glioblastoma: Dr. Iyad Alnahhas interviews Drs. Vinay Puduvalli and Ying Yuan about their paper "A Bayesian adaptive randomized phase II multicenter trial of bevacizumab with or without vorinostat in adults with recurrent glioblastoma" published in Neuro-Oncology... by Neuro-Oncology: The Podcast
33 min listen
DNA methylation profiles within the CATNON trial: Dr. Iyad Alnahhas interviews Dr. Pim French about his and his team recent manuscript entitled: "Prognostic significance of genome-wide DNA methylation profiles within the randomised, phase 3, EORTC CATNON trial on non-1p19q deleted anaplastic glioma",... by Neuro-Oncology: The Podcast
18 min listen
A prospective phase II randomized trial of proton radiotherapy vs intensity modulated radiotherapy for patients with newly diagnosed GBM: Dr. Jasmin Jo interviews Dr. Caroline Chung about her paper: “A prospective phase II randomized trial of proton radiotherapy vs intensity modulated radiotherapy for patients with newly diagnosed GBM” published online in Neuro-Oncology in Feb 2021. by Neuro-Oncology: The Podcast
14 min listen
Testing methods for MGMT promoter methylation: Dr. Iyad Alnahhas interviews Dr. Kathreena Kurian about her and her team's recent manuscript entitled: "MGMT promoter methylation testing to predict overall survival in people with glioblastoma treated with temozolomide: a comprehensive meta-analysis... by Neuro-Oncology: The Podcast
13 min listen
The incidence of brain metastases among patients with metastatic breast cancer: Dr. Iyad Alnahhas interviews Dr. Katarzyna Jerzak about her recent paper “The incidence of brain metastases among patients with metastatic breast cancer: a systematic review and meta-analysis”, published online in Neuro-Oncology in December,... by Neuro-Oncology: The Podcast
24 min listen
Friends of SNO: In this premiere episode, we will bring you some brief conversations with the current leaders of: The Society for Neuro-Oncology, the European Association of Neuro-Oncology, The Asian Society for Neuro-Oncology and the World Federation of... by Neuro-Oncology: The Podcast
26 min listen
Cold-Inducible RNA-Binding Protein expression and recurrence of brain metastases: Dr. Alireza Mansouri interviews Dr. Matthew Dankner about his recent paper "Invasive growth associated with Cold-Inducible RNA-Binding Protein expression drives recurrence of surgically resected brain metastases" published online in Neuro-Oncology in... by Neuro-Oncology: The Podcast
11 min listen
Supratotal resection of lower-grade gliomas: Dr. Alireza Mansouri talks with Dr. Lorenzo Bello about his recently published article in Neuro-Oncology entitled: "Association of Supratotal Resection with Progression-Free Survival, Malignant Transformation, and Overall Survival in Lower-Grade... by Neuro-Oncology: The Podcast
19 min listen
A subset of pediatric thalamic gliomas: Dr. Iyad Alnahhas talks with Dr. Felix Sahm about his recently published article in Neuro-Oncology entitled: "A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR,"... by Neuro-Oncology: The Podcast
21 min listen
Brain radiotherapy and decline in fine motor skills: Dr. Iyad Alnahhas interviews Dr. Jona Hattangadi-Gluth and Ms. Mia Salans about their recently published manuscript entitled: "Longitudinal change in fine motor skills after brain radiotherapy and in vivo imaging biomarkers associated with... by Neuro-Oncology: The Podcast
18 min listen
Temozolomide-induced hypermutation in IDH-mutant low-grade gliomas: Dr. Maya Graham interviews Dr. Nancy Ann Oberheim Bush about her and her team's paper entitled " Temozolomide-induced hypermutation is associated with distant recurrence and reduced survival after high-grade transformation of low-grade IDH-mutant... by Neuro-Oncology: The Podcast
13 min listen
A serum based DNA methylation assay to detect gliomas: Dr. Iyad Alnahhas interviews Dr. Houton Noushmehr about his recent paper "A serum-based DNA methylation assay provides accurate detection of glioma", published online in Feb 2021 in Neuro-Oncology by Neuro-Oncology: The Podcast
33 min listen
Loss of H3K27me3 in the Tübingen meningioma cohort: Dr. Maya Graham interviews Drs. Ghazaleh Tabatabai and Felix Behling about their paper entitled “H3K27me3 loss indicates an increased risk of recurrence in the Tübingen meningioma cohort” published online in Neuro-Oncology in December 2020. by Neuro-Oncology: The Podcast
18 min listen
PTEN deficiency and proteosome addiction in glioblastoma: Dr. Evan Noch interviews Drs. Frank Furnari and Jorge Benitez about their recent paper: "PTEN deficiency leads to proteosome addiction, a novel vulnerability in glioblastoma" published online in Neuro-Oncology in January, 2021. by Neuro-Oncology: The Podcast
23 min listen
A large longitudinal study of patients with Neurofibromatosis Type 2.: Dr. Iyad Alnahhas interviews Dr. Gareth Evans about his recent paper in Neuro-Oncology entitled: "Disease course of Neurofibromatosis Type 2; a 30-year follow-up study of 353 patients seen at a single institution by Neuro-Oncology: The Podcast
21 min listen
Molecular signatures of glioma causation: Dr. Evan Noch interviews Dr. Elizabeth Claus about her recent manuscript entitled: "Environmental and sex-specific molecular signatures of glioma causation" published online in Neuro-Oncology in May 2021. by Neuro-Oncology: The Podcast
22 min listen
Checkpoint blockade in atypical meningiomas: Description: Dr. Nicholas Butowski interviews Dr. David Reardon about his recent manuscript "Activity of PD-1 blockade with nivolumab among patients with recurrent atypical/anaplastic meningioma: phase II trial results", published online in... by Neuro-Oncology: The Podcast
40 min listen
18F FET PET in childhood CNS tumors: Description: Dr. Maya Graham interviews Dr. Lisbeth Marner about her recent manuscript "" Diagnostic accuracy and clinical impact of 18F FET PET in childhood CNS tumors" " published online in April 2021 in Neuro-Oncology. by Neuro-Oncology: The Podcast
18 min listen
Immunotherapy for melanoma brain metastases: Dr. Ankush Bhatia interviews Dr. Hussein Tawbi about his and his team's recent manuscript entitled "Safety and efficacy of the combination of nivolumab plus ipilimumab in patients with melanoma and asymptomatic or symptomatic brain... by Neuro-Oncology: The Podcast
33 min listen
Epidemiology of Brainstem High-Grade Gliomas in Children and Adolescents in the United States, 2000-2017: Dr. Evan Noch interviews Dr. Jill Barnholtz-Sloan about her recent paper "Epidemiology of Brainstem High-Grade Gliomas in Children and Adolescents in the United States, 2000-2017" published online in Neuro-Oncology in December 2020. by Neuro-Oncology: The Podcast
17 min listen
Loss of H3K27me3 in meningiomas: Dr. Evan Noch interviews Drs. Farshad Nassiri and Justin Wang from the team of Dr. Gelareh Zadeh about their recently published paper entitled “Loss of H3K27me3 in meningiomas” published online in Neuro-Oncology in May 2021. by Neuro-Oncology: The Podcast
26 min listen
BOLD fMRI in IDH mutant gliomas: Dr. Ankush Bhatia interviews Dr. Jack Grinband about his recent manuscript entitled "BOLD Asynchrony Elucidates Tumor Burden in IDH-Mutated Gliomas", published online in Neuro-Oncology in July 2021 by Neuro-Oncology: The Podcast
29 min listen
Immunosuppression in IDH mutant gliomas: Dr. Maya Graham interviews Dr. Nduka Amankulor about the recent manuscript entitled: "Characterization of systemic immunosuppression by IDH mutant glioma small extracellular vesicles" published online in Neuro-Oncology in July 2021. by Neuro-Oncology: The Podcast
30 min listen
Resection for recurrent brain metastases: Dr. Iyad Alnahhas interviews Dr. Alexander Hulsbergen about his and his team's recent manuscript entitled: "Neurosurgical resection for locally recurrent brain metastases", published online in Neuro-Oncology in July 2021. by Neuro-Oncology: The Podcast
16 min listen
Posterior fossa syndrome: Dr. Iyad Alnahhas interviews Dr. Raja Khan about their recent manuscript entitled "Clinical features, neurologic recovery, and risk factors of post-operative posterior fossa syndrome and delayed recovery: a prospective study", published online in... by Neuro-Oncology: The Podcast
22 min listen
Cell-free DNA from CSF in pediatric, adolescent and young adult patients: Dr. Iyad Alnahhas interviews Dr. Matthias Karajannis about his and his team's recent manuscript entitled: "Next-generation sequencing of cerebrospinal fluid for clinical molecular diagnostics in pediatric, adolescent and young adult (AYA) brain tumor... by Neuro-Oncology: The Podcast
11 min listen
Moleculary integrated grading for meningioma: Dr. Nicholas Butowski interviews Drs. Sandro Santagata and Wenya Linda Bi about their recent manuscript entitled: "A molecularly integrated grade for meningioma", published online in Neuro-Oncology in September 2021. by Neuro-Oncology: The Podcast
29 min listen
Selumetinib in children with NF1 and plexiform neurofibroma: Dr.Iyad Alnahhas interviews Drs. Andrea Gross and Brigitte Widemann about their manuscript entitled "Selumetinib in Children with Neurofibromatosis Type 1 and Asymptomatic Inoperable Plexiform Neurofibroma at Risk for Developing Tumor-Related... by Neuro-Oncology: The Podcast
24 min listen
The clinical utility of next generation sequencing for IDHwt glioblastoma: Dr. Evan Noch interviews Dr. Mary Jane Lim-Fat about her and her team's recent manuscript entitled: "Clinical utility of targeted next generation sequencing assay in IDH-wildtype glioblastoma for therapy decision-making", published online in... by Neuro-Oncology: The Podcast
22 min listen

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Long-term outcomes of pediatric patients with optic pathway glioma: Dr. Iyad Alnahhas interviews Drs. Alice Morin, Samuel Abbou and Brice Fresneau about their recent manuscript entitled "Very long-term outcomes of pediatric patients treated for optic pathway gliomas: a longitudinal cohort study" published online in... by Neuro-Oncology: The Podcast
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Postoperative cerebellar mutism: Dr. Rachna Malani interviews Dr. Hrishikesh Suresh about his and his team's recent manuscript entitled "Postoperative cerebellar mutism syndrome is an acquired Autism-like network disturbance", published online in Neuro-Oncology in December 2023. by Neuro-Oncology: The Podcast
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Cell cycle checkpoints and alkylating agents: Dr. Evan Noch interviews Dr. Chunzhang Yang about his and his team's recent manuscript entitled "Abrogation of the G2/M checkpoint as a chemo sensitization approach for alkylating agents" published online in Neuro-Oncology in December 2023 by Neuro-Oncology: The Podcast
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Liquid biopsy in CNS lymphoma: Dr. Iyad Alnahhas interviews Dr. Ricardo Soffietti about the recent RANO review entitled "Liquid biopsy for improving diagnosis and monitoring of CNS lymphomas: a RANO review" published online in Neuro-Oncology in March 2024. by Neuro-Oncology: The Podcast
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Immunotherapy for glioblastoma, lessons learned: Dr. John Fortunato interviews Dr. Antonio Chiocca about his and his team's recent manuscript entitled "Lessons learned from phase 3 trials of immunotherapy for glioblastoma: time for longitudinal sampling?" published online in Neuro-Oncology in... by Neuro-Oncology: The Podcast
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TERTp mutation clonality in glioma: Dr. Maya Graham interviews Dr. Joseph Costello about his and his team's recent manuscript entitled "Whole tumor analysis reveals early origin of the TERT promoter mutation and intracellular heterogeneity in TERT expression", published online in... by Neuro-Oncology: The Podcast
33 min listen
Liquid biopsy in H3K27M glioma: Description: Dr. Maya Graham interviews Dr. Carl Koschmann about his and his team's recent manuscript entitled: "Liquid biopsy in H3K27M diffuse midline glioma", published online in Neuro-Oncology in December 2023. by Neuro-Oncology: The Podcast
27 min listen
Glioma genetic profiles and electrophysiologic hyperexcitability: Dr. Iyad Alnahhas interviews Dr. Steven Tobochnik about his and his team's recent manuscript entitled "Glioma genetic profiles associated with electrophysiologic hyperexcitability", published online in Neuro-Oncology in Sep 2023. by Neuro-Oncology: The Podcast
22 min listen
Epidemiology of glioma in Belgium: Dr. Jasmin Jo interviews Dr. Harry Pinson about his and his team's recent manuscript entitled: "Epidemiology and survival of adult-type diffuse glioma in Belgium during the molecular era" by Neuro-Oncology: The Podcast
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The Biology of H3K27M Mutant Gliomas: Dr. Iyad Alnahhas interviews Dr. Amanda Saratsis about her recent manuscript entitled: "H3K27M Mutant Glioma: Disease Definition and Biological Underpinnings", published online in Neuro-Oncology in October 2023. by Neuro-Oncology: The Podcast
15 min listen
3D tumor volume assessment in PCNSL: Dr. Rachna Malani interviews Dr. Florian Scherer about his and his team's recent manuscript entitled: "Improved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas", published online in Neuro-Oncology in Sep... by Neuro-Oncology: The Podcast
28 min listen
Brain-tumor related epilepsy; a SNO consensus review: Dr. John Fortunato interviews Drs. Edward Avila and Steven Tobochnik about their recent manuscript entitled: "Brain tumor-related epilepsy management: A society for neuro-oncology consensus review on current management", published online in... by Neuro-Oncology: The Podcast
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Vorasidenib and grading of IDH mutant astrocytoma: Description: Dr. Ankush Bhatia interviews Dr. Matthias Preusser about the recent letter in Neuro-Oncology, entitled: "What is an isocitrate dehydrogenase-mutated central nervous system World Health Organization grade 2 glioma, or who should receive... by Neuro-Oncology: The Podcast
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SOX10 indel mutations in schwannomas: Dr. Evan Noch interviews Dr. David Solomon about his and his team's recent manuscript entitled: "Novel SOX10 indel mutations drive schwannomas through impaired transactivation of myelination gene programs", published online in Neuro-Oncology in July... by Neuro-Oncology: The Podcast
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Dendritic cell vaccines in gliomas: Dr. Iyad Alnahhas interviews Drs. Kelly Hotchkiss and Mustafa Khasraw about their recently published review entitled: "Dendritic cell vaccine trials in gliomas: untangling the lines", published online in Neuro-Oncology in June 2023. by Neuro-Oncology: The Podcast
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Intrathecal trastuzumab for leptomeningeal metastases: Dr. Iyad Alnahhas interviews Drs. Priya Kumthekar and Jeffrey Raizer about their recent manuscript entitled: A phase I/II study of intrathecal trastuzumab in human epidermal growth factor receptor 2-positive (HER2- positive) cancer with leptomeningeal... by Neuro-Oncology: The Podcast
21 min listen
Short term topiramate for radiation induced cytotoxic edema: Dr. Iyad Alnahhas interviews Drs. Maria Jose Contreras-Zarate and Diana Cittelly about their recent manuscript entitled: "Short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain... by Neuro-Oncology: The Podcast
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Venous thromboembolism in gliomas: Description: Dr. Maya Graham interviews Drs. Jasmin Jo, Craig Horbinski and David Schiff about their recent manuscript entitled: "Epidemiology, biology and management of venous thromboembolism in gliomas: an interdisciplinary review", published... by Neuro-Oncology: The Podcast
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RANO resect: Dr. Iyad Alnahhas interviews Dr. Philipp Karschnia about his and his team's recent manuscript entitled "Prognostic validation of a new classification system for extent of resection in glioblastoma: A report of the RANO resect group", published... by Neuro-Oncology: The Podcast
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Methylation profiling of adult ependymoma: Dr. Evan Noch interviews Dr. David Kaul about his and his team's recent manuscript entitled: "Adult intracranial ependymoma—relevance of DNA methylation profiling for diagnosis, prognosis, and treatment", published online in Neuro-Oncology in... by Neuro-Oncology: The Podcast
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Pseudoprogression in IDH-mutant high-grade gliomas: Dr. Ankush Bhatia interviews Dr.François Ducray about his and his team's recent manuscript entitled:"Incidence and characteristics of pseudoprogression in IDH-mutant high-grade gliomas: A POLA network study", published online in Neuro-Oncology... by Neuro-Oncology: The Podcast
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Changes in survival outcomes in melanoma patients with brain metastases: Dr. Iyad Alnahhas interviews Drs. Sherise Ferguson and Michael Davies about their recent manuscript entitled: "Changes in Outcomes and Factors Associated with Survival in Melanoma Patients with Brain Metastases", published online in... by Neuro-Oncology: The Podcast
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Radiation therapy and structural brain changes: Dr. Evan Noch interviews Drs. Nikhil Rammohan and Kathleen Bandt about their recent manuscript entitled "Whole-brain radiotherapy associated with structural changes resembling aging as determined by anatomic surface-based deep learning", published... by Neuro-Oncology: The Podcast
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Objective response rate targets for recurrent glioblastoma clinical trials: Dr. Maya Graham interviews Drs. Benjamin Ellingston and Timothy Cloughesy about their recently published manuscript entitled: "Objective response rate (ORR) targets for recurrent glioblastoma clinical trials based on the historic association between... by Neuro-Oncology: The Podcast
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Mitotic count prognostic significance in IDH-mutant astrocytoma in the molecular era: Dr. Iyad Alnahhas interviews Dr. Max Kros about his and his team's recent manuscript entitled: "Mitotic count is prognostic in IDH-mutant astrocytoma without homozygous deletion of CDKN2A/B. Results of consensus panel review of EORTC trials 26053 and... by Neuro-Oncology: The Podcast
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Palliative care in neuro-oncology: Dr. Iyad Alnahhas interviews Drs. Tobias Walbert and Johan Koekkoek about their recent manuscript entitled "Palliative care and end-of-life care in adults with malignant brain tumors", published online in Neuro-Oncology in October 2022 by Neuro-Oncology: The Podcast
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Glioblastoma subtypes and response to Dasatinib: Dr. Evan Noch interviews Drs. Emma Phillips and Violaine Goidts about their recent manuscript entitled "A Novel Patient Stratification Strategy to Enhance the Therapeutic Efficacy of Dasatinib in Glioblastoma", published online in... by Neuro-Oncology: The Podcast
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Discontinuing Immunosuppressant Use after Allograft Failure: Do We Have the Answers?: Dr. Briggs summarizes findings in a study published in the June issue of JASN. The study examines the impact of continued immunosuppression in patients with failed allografts; the effects are surprising and suggest current guidelines may not be optimum. by Journal of the American Society of Nephrology (JASN)
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Insulin feedback and PI3K inhibition in GBM

Insulin feedback and PI3K inhibition in GBM

Description

Titles in the series (79)

More Episodes from Neuro-Oncology: The Podcast

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