In this episode, hosts Marla Dalton, PE, CAE, and William Schaffner, MD, talk with Rochelle P. Walensky, MD, MPH, former director of the Centers for Disease Control and Prevention (CDC), who was deeply involved in the responses to some of the biggest public health threats of the past 5 decades including HIV/AIDS and COVID-19. She shares some of the most significant changes she has seen throughout her career, how the HIV/AIDS epidemic shaped her work, the importance of rebuilding trust in CDC and other government agencies, and predictions for the upcoming cold and flu season.