During this episode of SurgOnc Today, Alexander Parikh, MD, MPH, Chair of the SSO HPB DSWG, is joined by Ana Luiza Gleisner, MD, PhD, from the University of Colorado Anschutz Medical Campus in Aurora, CO and Shimul A. Shah, MD, MHCM, from the University of Cincinnati College of Medicine in Cincinnati, OH. They review the role of liver transplantation for malignancies of and to the liver. In this first installment of the two-part series, they discuss the role of liver transplantation in the treatment of primary hepatobiliary malignancies including hepatocellular cancer and cholangiocarcinoma.