This first episode in our three-parter on non-nutritive sweeteners is about the artificial stuff, the most-accidental discoveries that led to saccharin, aspartame, sucralose, all the big ones, all the hits! How do these synthetic sweeteners work? How do they differ from one another?
Next week we'll cover 'natural' non-nutritive sweeteners and the week after that we'll cover whether there are any risks to their frequent use!
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References:

https://www.acs.org/content/acs/en/molecule-of-the-week/archive/s/saccharin.html
https://www.saveur.com/artificial-sweeteners/
https://www.mentalfloss.com/article/83730/sweet-and-not-so-sweet-history-saccharin
https://www.nature.com/articles/243347a0
https://pubmed.ncbi.nlm.nih.gov/15537898/
https://www.sciencedirect.com/science/article/pii/S0304394018302908
https://www.sciencedirect.com/science/article/pii/S2451945617302787
https://www.sciencedirect.com/science/article/pii/S0271531719300491
https://www.taylorfrancis.com/chapters/edit/10.1201/9781003065289-2/discovery-aspartame-robert-mazur
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856475/