Editor's note: Serena Orr, MD, is a clinician-scientist and assistant professor of pediatrics and clinical neurosciences at the University of Calgary, and an attending pediatric neurologist at the Alberta Children's Hospital (ACH), where she directs the pediatric headache program in the section of neurology. Dr. Orr's research focuses on improving the acute treatment of migraine in children and adolescents and also aims to identify biopsychosocial predictors of outcomes in children and adolescents with migraine, and how these may be used to apply stratified care models to migraine prevention.  In this MSC podcast she speaks with MSC freelance writer Kayt Sukel to discuss her path to pediatric migraine research, some of her recent work on the role of anxiety and depression in kids with migraine, how adverse childhood experiences affect pediatric migraine, as well as the need for more funding of headache research.