Discover this podcast and so much more

Podcasts are free to enjoy without a subscription. We also offer ebooks, audiobooks, and so much more for just $11.99/month.

Episode: 46 - Leveraging Albumin and IgG FcRn-Mediated Regulation in Therapeutic Development

Episode: 46 - Leveraging Albumin and IgG FcRn-Mediated Regulation in Therapeutic Development

FromThe Chain: Protein Engineering Podcast


Episode: 46 - Leveraging Albumin and IgG FcRn-Mediated Regulation in Therapeutic Development

FromThe Chain: Protein Engineering Podcast

ratings:
Length:
36 minutes
Released:
Mar 14, 2023
Format:
Podcast episode

Description

Jan Terje Andersen, professor of biomedical innovation in the Department of Pharmacology at the University of Oslo and research group leader in the Department of Immunology at the Oslo University Hospital, has spent nearly two decades studying neonatal Fc receptors (FcRns) and their interactions with prominent blood proteins albumin and IgG. He sits down with moderator Nimish Gera, vice president of biologics at Mythic Therapeutics, to discuss the unique properties of FcRn and how it can be leveraged for novel therapeutic development. Additionally, Andersen details the mechanics of FcRn binding, why it prolongs albumin and IgG half-lives, and notable FcRn technological advancements and research findings in animal and human models. He also talks about engineering blood proteins for optimal function and launching his new venture, Authera, the preclinical stage biotech company using an FcRn-centered platform to study the receptor’s versatility across multiple cell types. Links from this episode:  University of Oslo Mythic Therapeutics Authera 
Released:
Mar 14, 2023
Format:
Podcast episode

Titles in the series (63)

The Chain explores the lives, careers, research, and discoveries of protein engineers and scientists, the impact their work is having on the field, and where the industry is headed. Tune in to stay up-to-date on the newest advancements and to hear the stories that are impacting the world of biologics.