In an increasingly politicized world, it’s harder and harder for CEOs to keep business and politics separate. And in an increasingly politicized world, they shouldn’t. When an issue creates risks that are severe, broad in scope, and systemic in impact, business leaders have an obligation to speak up, especially if the issue clashes with the company’s ethics, culture, and vision for the future. Reid Hoffman and Blitzscaling co-author Chris Yeh outline a set of principles that can help decide when, how, and why CEOs should speak out.