20 min listen
Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle
Ipsilateral restriction of chromosome movement along a centrosome, and apical-basal axis during the cell cycle
ratings:
Length:
20 minutes
Released:
Mar 29, 2023
Format:
Podcast episode
Description
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2023.03.27.534352v1?rss=1
Authors: Cai, P., Casas, C. J., Hua, L. L., Mikawa, T.
Abstract:
Individual homologous chromosomes are spatially segregated into haploid chromosome sets along the centrosome axis in an antipairing configuration. Disruption of the antipairing pattern occurs in cancer cells. However, little is known about how this spatial organization of chromosomes is established or maintained. Here, we report that there is a zone of diminished interchromosomal linkage and centromere components between haploid sets in primary and established human epithelial cell lines. Using 4-Dimensional live cell imaging analysis of centromere and centrosome tracking, we show ipsilateral restriction of chromosome oscillations along the diminished zone, coincident with the centrosome and apical-basal axis from mitosis onset to G1 interphase. We propose a biophysical model of axis-dependent ipsilateral restriction of chromosome oscillations for haploid set organization.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
http://biorxiv.org/cgi/content/short/2023.03.27.534352v1?rss=1
Authors: Cai, P., Casas, C. J., Hua, L. L., Mikawa, T.
Abstract:
Individual homologous chromosomes are spatially segregated into haploid chromosome sets along the centrosome axis in an antipairing configuration. Disruption of the antipairing pattern occurs in cancer cells. However, little is known about how this spatial organization of chromosomes is established or maintained. Here, we report that there is a zone of diminished interchromosomal linkage and centromere components between haploid sets in primary and established human epithelial cell lines. Using 4-Dimensional live cell imaging analysis of centromere and centrosome tracking, we show ipsilateral restriction of chromosome oscillations along the diminished zone, coincident with the centrosome and apical-basal axis from mitosis onset to G1 interphase. We propose a biophysical model of axis-dependent ipsilateral restriction of chromosome oscillations for haploid set organization.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
Released:
Mar 29, 2023
Format:
Podcast episode
Titles in the series (100)
Olfactory chemosensation extends lifespan through TGF-β signaling and UPR activation by PaperPlayer biorxiv cell biology