Roxadustat and the Interpretation of Non-Inferiority

A Conversation with Deidre Crews and Tanjala Purnell about COVID-19, Structural Racism and Kidney Disease: This episode, JASN's inaugural podcast, is a conversation with Drs. Tanjala Purnell and Deidre Crews, about the impact of the COVID-19 epidemic on kidney patients, particularly the disproportionate impact on people of color. by Journal of the American Society of Nephrology (JASN)

21 min listen

New Insights into the Mechanisms of Kidney Disease: Understanding Hypercholesterolemia in CKD; ADAM10 and Immune Injury to the Podocyte Slit Diaphragm: Two papers published this month in JASN provide new insights into these unsolved questions: Why is the risk of atherosclerotic cardiovascular disease so high in kidney patients? Why is the podocyte slit diaphragm so vulnerable to immunological injury? by Journal of the American Society of Nephrology (JASN)

6 min listen

JASN March 2021 Issue Highlights: Every issue of JASN includes Highlights, which are short summaries of 5-6 articles hand picked by the EIC for their interest and impact. by Journal of the American Society of Nephrology (JASN)

10 min listen

A Dialogue with Mahboob Rahman and Erin Barreto About Ambulatory Blood Pressure Monitoring in Patients with Chronic Kidney Disease by Journal of the American Society of Nephrology (JASN)

19 min listen

A Discussion with Andrew Malone and Madhav Menon: RNAseq and the Transplant Biopsy, What is New?: In this podcast, JASN Editorial Fellow Dr. Madhav Menon, discusses with Dr. Andrew Malone a novel application of RNAseq to the transplant biopsy. by Journal of the American Society of Nephrology (JASN)

23 min listen

JASN January 2021 Issue Highlights: Every issue of JASN includes Highlights, which are short summaries of 5-6 articles hand picked by the EIC for their interest and impact. by Journal of the American Society of Nephrology (JASN)

8 min listen

JASN May 2022 Issue Highlights: Every issue of JASN includes Highlights, which are short summaries of 5-6 articles hand-picked by the EIC for their interest and impact. by Journal of the American Society of Nephrology (JASN)

11 min listen

JASN August 2021 Issue Highlights: A few articles in each issue are chosen by the EIC for their interest. The issue highlights include: laminin-521 –a novel GBM autoantigen, iron biomarkers & mortality in nondialysis kidney disease, & disparities among hemodialysis patients with COVID-19. by Journal of the American Society of Nephrology (JASN)

7 min listen

A Conversation with Mark Knepper and Josie Briggs: Does SARS-CoV2 Infect the Kidney?: This episode of the JASN Podcast is a discussion between JASN EIC, Josie Briggs and Deputy Editor, Mark Knepper about the question: Does SARS CoV2 Infect the Kidney? by Journal of the American Society of Nephrology (JASN)

14 min listen

JASN February 2021 Issue Highlights: Every issue of JASN includes Highlights, which are short summaries of 5-6 articles hand picked by the EIC for their interest and impact. by Journal of the American Society of Nephrology (JASN)

9 min listen

Vaccine Acceptability and Hemodialysis Patients: A discussion between Dr. Magdalene Assimon, one of the JASN editorial fellows and study authors Dr. Pablo Garcia and Dr. Shuchi Anand on their recent JASN paper titled, "SARS-CoV-2 Vaccine Acceptability in Patients on Hemodialysis: A Nationwide Survey." by Journal of the American Society of Nephrology (JASN)

18 min listen

Lost Opportunities for Kidney Transplant: Transplant candidates with top 20% Estimated Post-Transplant Survival (EPTS) scores are prioritized to receive optimal deceased-donor kidneys. A study found fewer than half of eligible ESKD patients w/ top 20% EPTS scores were on transplant waiting list. by Journal of the American Society of Nephrology (JASN)

5 min listen

JASN April 2021 Issue Highlights: Every issue of JASN includes Highlights, which are short summaries of 5-6 articles hand-picked by the EIC for their interest and impact. by Journal of the American Society of Nephrology (JASN)

9 min listen

The Renal Framingham - CVD Prediction: Kidney patients are at high risk for cardiovascular disease. In this Podcast, Dr. Briggs talks and Dr. David Charytan discuss recent work to improve the prediction of CVD in kidney patients. New work from CRIC aims to update the Framingham equation. by Journal of the American Society of Nephrology (JASN)

23 min listen

COVID-19 Mortality and the Tough Discussions about Advance Care Planning: The June issue of JASN features new population level data from CMS on the real burden of the pandemic for dialysis and transplant patients in the US. These grim numbers remind us of the important role nephrologists play in Advance Care Planning. by Journal of the American Society of Nephrology (JASN)

8 min listen

The Immune Responses to COVID-19 in Transplant Patients: In this podcast JASN EIC, Josie Briggs talks with transplant expert and JASN Associate Editor, Matt Griffin about two studies that examine the immune responses to COVID-19 in transplant patients. by Journal of the American Society of Nephrology (JASN)

14 min listen

New Directions for Clinical Trials in Kidney Disease: A conversation with EIC, Josie Briggs and leading nephrology clinical trialist, Vlado Perkovic - on the next generation of clinical trials in nephrology. by Journal of the American Society of Nephrology (JASN)

32 min listen

Lowering GFR to Protect GFR!: In this episode, Dr. Josie Briggs and Dr. Brendon Neuen discuss the GFR paradox: SGLT inhibitors and other kidney-protective drugs initially cause a drop in GFR. by Journal of the American Society of Nephrology (JASN)

19 min listen

JASN November 2021 Issue Highlights: Each issue of JASN contains Highlights, short summaries of a few of the articles in the issue, chosen by the EIC as of special interest to our readers. by Journal of the American Society of Nephrology (JASN)

10 min listen

Roxadustat and the Interpretation of Non-Inferiority: In this Podcast, JASN EIC, Josie Briggs, discusses a clinical trial from the April issue on roxadustat in dialysis patients with Magdalene Assimon. Dr. Assimon explains the interpretation of the finding that roxadustat is non-inferior to epoetin alpha. by Journal of the American Society of Nephrology (JASN)

16 min listen

JASN May 2022 Highlights: Inflammation as a Driver of CKD Progression: In the May 2022 JASN highlights, Dr. Briggs summarizes two important studies on the role of inflammation as a driving factor in the progression of CKD. by Journal of the American Society of Nephrology (JASN)

9 min listen

The Extracellular Matrix in Development, Aging, and Disease: The extracellular matrix (ECM) biomechanically regulates nephrogenesis, and abnormal ECM is a histologic feature of kidney aging and disease. Two reports in this issue use state-of-the-art methods to characterize the ECM in development, aging and disease. by Journal of the American Society of Nephrology (JASN)

4 min listen

Gender Differences in Care of CKD Patients: In this podcast, JASN EIC, Josie Briggs talks with Juan-Jesus Carrero, Professor of Kidney Disease Epidemiology at Karolinska Institute. His study, published in the October issue of JASN, documents striking differences in care of men and women with CKD. by Journal of the American Society of Nephrology (JASN)

12 min listen

JASN October 2021 Issue Highlights: Each issue of JASN contains Highlights, short summaries of a few of the articles in the issue, chosen by the EIC as of special interest to our readers. by Journal of the American Society of Nephrology (JASN)

9 min listen

Comparing Costs of Hemodialysis and Peritoneal Dialysis: In this podcast, EIC Josie Briggs talks with Lekha Tummalapalli about a study addressing costs of hemodialysis and peritoneal dialysis. An editorial on this issue is published in the November (33.11) issue of JASN. by Journal of the American Society of Nephrology (JASN)

18 min listen

A New Approach to Advance Care Planning for Dialysis Decisions: Deciding not to Decide: In this podcast Dr. Briggs talks with Dr. Kate Butler about advance care planning for patients with chronic kidney disease. by Journal of the American Society of Nephrology (JASN)

22 min listen

Insights into Collapsing Glomerulopathy: Josie Briggs talks with Nicholas Steers about his work using inbred mice strains to understand the genetic factors that result in collapsing focal segmental glomerulosclerosis in HIV nephropathy, insights also relevant to a rare complication of COVID-19 by Journal of the American Society of Nephrology (JASN)

17 min listen

Discontinuing Immunosuppressant Use after Allograft Failure: Do We Have the Answers?: Dr. Briggs summarizes findings in a study published in the June issue of JASN. The study examines the impact of continued immunosuppression in patients with failed allografts; the effects are surprising and suggest current guidelines may not be optimum. by Journal of the American Society of Nephrology (JASN)

6 min listen

Highlights in Renal Transplantation: In this podcast, EIC Dr Briggs discusses two studies on kidney transplantation with Dr. John Gill. Topics discussed include novel molecular markers and the role of HLA-DQ mismatches, work suggesting new approaches to reduce chronic graft loss. by Journal of the American Society of Nephrology (JASN)

23 min listen

Addressing Racial and Ethnic Disparities in Kidney Disease: In this podcast, Dr. Briggs and JASN Deputy Editor, Dr. Donald Wesson discuss the special series highlighted in the July Issue. The series focuses on kidney health disparities with an emphasis on strategies for their elimination. by Journal of the American Society of Nephrology (JASN)

21 min listen

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Roxadustat and the Interpretation of Non-Inferiority

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