In this episode, Timothy J. Wilkin, MD, MPH, provides a case-based overview of switching antiretroviral therapy in a patient with viral suppression on their current regimen who has a history of virologic failure with drug-resistance mutations. Key findings from 2 relevant studies—the SWITCHMRK trial and Study 380-4030—are reviewed. The case discussion also highlights several other challenges that can be encountered in the switch setting, including incomplete immune recovery, comorbidities, and gastrointestinal intolerability of some antiretroviral drugs.Presenter:Timothy J. Wilkin, MD, MPH​Professor Medicine​Division of Infectious Diseases​Weill Medical College of Cornell University​New York, New YorkContent based on an online CME/CE program supported by an independent educational grant from ViiV Healthcare. Link to full program: https://bit.ly/3VIsDTgFollow along with the slides at https://bit.ly/3DdP3F6