In this episode, Dr. Kuritzkes and Dr. Ramers provide a case-based discussion addressing several age-related comorbidities among people with HIV, including bone loss, renal impairment, cardiovascular disease, mental health disorders, and neurocognitive disorders. Their discussion includes analysis of key data from the following HIV studies: DRIVE-AHEAD: Neuropsychiatric Events With First-line DOR/3TC/TDF vs EFV/FTC/TDFTANGO: Renal and Bone Changes With Switch to DTG/3TCSWORD-1/2: Renal and Bone Changes With Switch to DTG + RPVStudy 1961: Quantitative Proteinuria by Baseline Regimen With Switch to BIC/FTC/TAF in WomenStudies 1216 and 1160: Bone Changes With Switch to RPV/FTC/TAFNA-ACCORD: Increased MI Risk Among PWHD:A:D: Increased CVD Risk With Boosted PIsDanish HIV Cohort Study: Impact of Smoking on MI RiskD:A:D: Impact of Smoking on MI RiskIn addition, Dr. Kuritzkes and Dr. Ramers discuss relevant data and practical strategies for smoking cessation among people with HIV as well as risk factors, pathogenesis, and challenges in the clinical management of HIV-associated neurocognitive disorders.Presenters:Daniel R. Kuritzkes, MDChief, Division of Infectious DiseasesBrigham and Women’s HospitalHarriet Ryan Albee Professor of MedicineHarvard Medical SchoolBoston, MassachusettsChristian B. Ramers, MD, MPHAssociate Clinical ProfessorDivision of Infectious DiseasesDepartment of MedicineUC San Diego School of MedicineLa Jolla, CaliforniaChief, Population HealthDirector, Graduate Medical EducationFamily Health Centers of San DiegoSan Diego, CaliforniaContent based on an online CME program supported by an independent educational grant from ViiV Healthcare.Link to downloadable slideset associated with this podcast:  https://bit.ly/2MuoEHFLink to full program: https://bit.ly/3cFzy8o