In this episode from the series “Key Decisions in HIV Care,” Daria Podlekareva, MD, PhD, and Mark S. Sulkowski, MD, discuss important considerations for ART use in patients with coinfections, including:DHHS testing and treatment recommendations for HBV in patients with HIVData suggesting that tenofovir alone may not suppress HBV in all PWHData from NA-ACCORD showing that incomplete HBV DNA suppression is associated with HCC in patients with HIV/HBVData for the use of entecavir as an add-on therapy if an HIV ART regimen is not HBV activeData showing that lamivudine alone is associated with resistance in patients with HIV/HBVDiscussion of HBV management in the setting of 2-drug regimens for HIV if the patient is coinfectedRecommendations from the DHHS, EACS, and WHO to start ART as soon as possible in patients with TB/HIV coinfectionData from the SAPiT, ACTG A5221 STRIDE, and CAMELIA studies to show the benefits of early ART in patients with TB/HIVRecommendations from the EACS guidelines on what ART regimens are recommended with TB/HIVDrug-drug interaction considerations between ART and TB treatmentDiscussion of the prevention and management of TB-associated IRISPresenters:Daria Podlekareva, MD, PhDCentre of Excellence for Health, Immunity and Infection (CHIP)Rigshospital, University of CopenhagenCopenhagen, Denmark  Mark S. Sulkowski, MDProfessor of MedicineMedical Director, Viral Hepatitis CenterChief, Infectious DiseaseJohns Hopkins Bayview Medical CenterJohns Hopkins University School of MedicineBaltimore, MarylandContent based on an online CME program supported by educational grants from Gilead Sciences, Inc.; Janssen Therapeutics, Division of Janssen Products, LP; and ViiV Healthcare.Follow along with slides:https://bit.ly/3zHySMOSee the entire program at:https://bit.ly/2TXTYWx