"It does seem to hold true that ICSI is beneficial when you fertilize eggs that have been previously cryopreserved because there are some changes that occur in the zona pellucida and the structure of the egg itself." - Denis Vaughan, M.D. Intracytoplasmic sperm injection or ICSI is a micromanipulation procedure in which a single sperm is injected directly into an egg to attempt fertilization, used with male infertility or couples with prior IVF failure. There is a new updated document from ASRM on ICSI for non-male factor and we talk about it today on the podcast. View the document: Intracytoplasmic sperm injection (ICSI) for non–male factor indications: a committee opinion All ASRM Practice Committee documents can be viewed at ASRM.org If you'd like to know more about the types of practice documents and the methodology of their creation, visit this page on ASRM.org The ASRM Today podcast is supported in part by the ASRM Corporate Member Council.