20 min listen
Pioneer transcription factors coordinate active and repressive gene expression states to regulate cell fate
Pioneer transcription factors coordinate active and repressive gene expression states to regulate cell fate
ratings:
Length:
20 minutes
Released:
Dec 30, 2022
Format:
Podcast episode
Description
Link to bioRxiv paper:
http://biorxiv.org/cgi/content/short/2022.12.29.522251v1?rss=1
Authors: Matsui, S., Granitto, M., Buckley, M., Shiley, J., Zacharias, W., Mayhew, C., Lim, H.-W., Iwafuchi, M.
Abstract:
Pioneer transcription factors (TFs) regulate cell fate by establishing transcriptionally primed and active states. However, cell fate control requires the coordination of both lineage-specific gene activation and repression of alternative lineage programs, a process that is poorly understood. Here, we demonstrate that the pioneer TF Forkhead box A (FOXA), required for endoderm lineage commitment, coordinates with the PR domain zinc finger 1 (PRDM1) TF to recruit Polycomb repressive complexes, which establish bivalent enhancers and repress alternative lineage programs. Similarly, the pioneer TF OCT4 coordinates with PRDM14 to repress cell differentiation programs in pluripotent stem cells, suggesting this is a common feature of pioneer TFs. We propose that pioneer and PRDM TFs coordinate recruitment of Polycomb complexes to safeguard cell fate.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
http://biorxiv.org/cgi/content/short/2022.12.29.522251v1?rss=1
Authors: Matsui, S., Granitto, M., Buckley, M., Shiley, J., Zacharias, W., Mayhew, C., Lim, H.-W., Iwafuchi, M.
Abstract:
Pioneer transcription factors (TFs) regulate cell fate by establishing transcriptionally primed and active states. However, cell fate control requires the coordination of both lineage-specific gene activation and repression of alternative lineage programs, a process that is poorly understood. Here, we demonstrate that the pioneer TF Forkhead box A (FOXA), required for endoderm lineage commitment, coordinates with the PR domain zinc finger 1 (PRDM1) TF to recruit Polycomb repressive complexes, which establish bivalent enhancers and repress alternative lineage programs. Similarly, the pioneer TF OCT4 coordinates with PRDM14 to repress cell differentiation programs in pluripotent stem cells, suggesting this is a common feature of pioneer TFs. We propose that pioneer and PRDM TFs coordinate recruitment of Polycomb complexes to safeguard cell fate.
Copy rights belong to original authors. Visit the link for more info
Podcast created by Paper Player, LLC
Released:
Dec 30, 2022
Format:
Podcast episode
Titles in the series (100)
Alterations in platelet proteome signature and impaired platelet integrin αIIbβ3 activation in patients with COVID-19 by PaperPlayer biorxiv cell biology