Umar Mahmood, MD, PhD, and Andrei Iagaru, MD—the inaugural recipient of the Sam Gambhir Trailblazer Award—discuss Dr. Gambhir's life and legacy, including personal and professional recollections. Dr. Iagaru also shares his thoughts on the future of nuclear medicine therapies, what keeps him motivated, and more.This new SNMMI award was created in memory of Sanjiv 'Sam' Gambhir, MD, PhD, who passed away in July 2020. He was Professor and Chair of Radiology at the Stanford School of Medicine and an internationally recognized pioneer in molecular imaging. The Sam Gambhir Trailblazer Award honors outstanding achievement in excellence in transformative research (either basic science, translational science or clinical science) and exceptional mentorship for mid-career professionals.