Presented by John Rush, DVM, ACVIM Cardiology, ACVECC, Tufts University at the 34th Annual Winn Feline Foundation Symposium on Feline Health. There can be little doubt that genetic mutations contribute to many, if not all, forms of hypertrophic cardiomyopathy in the cat. However these mutations cannot explain all of the manifestations of the disease. Following a review of the commonly affected cats and the typical clinical signs, newer information and research is presented relative to diagnostic testing, dietary implications, and new drugs for treatment of feline cardiomyopathy. This presentation was originally delivered on June 28, 2012 at the 34th Annual Winn Feline Foundation Symposium on Feline Health.