In this episode of The Stem Cell Report, sponsored by Bio-Techne, we will explore the modeling of complex human neuropsychiatric diseases such as autism, bipolar disorder, and others using stem cell-based, three-dimensional culture models of the brain and its development. Martin Pera will be joined by Drs. Carol Marchetto and Rusty Gage, experts in the normal and pathological development of the brain. Carol Marchetto is an Assistant Professor in the Anthropology Department at the University of California, San Diego and an adjunct Assistant Professor at the Salk Institute. Rusty Gage is the Vi and John Adler Chair for Research on Age-Related Neurodegenerative Disease and the President of the Salk Institute for Biological Studies. He has received numerous awards and recognition for his research including his appointment as a Fellow of the National Academy of Medicine. He is a former president of the ISSCR and a current member of the Stem Cell Reports Editorial Board. HostMartin Pera, PhD – Editor-in-Chief, Stem Cell Reports and The Jackson LaboratoryTwitter: @martinperaJAXGuestsCarol Marchetto, PhD, University of California, San Diego, USA Rusty Gage, PhD, Salk Institute for Biological Studies, USA  Supporting ContentReaching into the toolbox: Stem cell models to study neuropsychiatric disordersEthical, Legal, and Regulatory Issues Associated with Neural Chimeras and OrganoidsAbout Stem Cell ReportsStem Cell Reports is the Open Access journal of the International Society for Stem Cell Research (ISSCR) for communicating basic discoveries in stem cell research, in addition to translational and clinical studies. Stem Cell Reports focuses on original research with conceptual or practical advances that are of broad interest to stem cell biologists and clinicians.Twitter: @StemCellReportsAbout ISSCRWith nearly 4,500 members from more than 70 countries, the International Society for Stem Cell Research is the preeminent global, cross-disciplinary, science-based organization dedicated to stem cell research and its translation to the clinic. The ISSCR mission is to promote excellence in stem cell science and applications to human health.Twitter: @ISSCRAcknowledgementsISSCR StaffKeith Alm, Chief Executive OfficerYvonne Fisher, Managing Editor, Stem Cell ReportsKym Kilbourne, Director of Media and Strategic CommunicationsJack Mosher, Scientific AdvisorVoice WorkBen SnitkoffMusic@Konovalov