On this week's episode we discuss mutations, specifically in the context of SARS-CoV-2. We set the stage by describing what a mutation is and how this random process occurs in all organisms. We discuss the emergence of SARS-CoV-2 and a primer on zoonotic diseases before focusing on mutation rates of SARS-CoV-2, and comparison to another RNA virus, influenza virus. We talk about the key mutations of the variants of concern B.1.1.7, B.1.351, and P.1 and the spike antigen of the virus, and why these mutations have become more prevalent. We wrap up with a discussion on the implications of vaccine efficacy in light of these new variants, and underscore the need for rapid vaccination globally.


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