Rami Doukky, MD, and editorialist Lisa K. Moores, MD, FCCP, meet in conversation with CHEST Podcast Editor, D. Kyle Hogarth, MD, FCCP to discuss Dr. Doukky et al's retrospective study showing that highly sensitive cardiac troponin I assay provides a good prognostic negative predictive value; consequently, it can play a role in identifying candidates for out-of-hospital treatment of acute PE.