From the initial development of the yellow fever vaccine to fractionated dosing in response to the 2016 Angola/DRC outbreak, a key part of the yellow fever story has long been the dedication, commitment and intellect that has gone into advancing the science that combats the disease. But with climate change posing new risks in new parts of the world, what innovation is happening now to help control and minimise vector-borne diseases like yellow fever? We hear from Dr Raman Velayudhan, unit head for vector control, veterinary public health and environment at WHO.