EP 77: The journey to novel gene therapies for hearing loss and balance disorders with Laurence Reid, CEO at Decibel Therapeutics

EP105: Warren Huff, CEO and Chairman of Reata Pharmaceuticals, shares perspectives on provocative biology and the development of treatments for rare diseases: In this episode, Patrick welcomes J. Warren Huff, CEO and Chairman of Reata Pharmaceuticals. Reata is known for innovating small-molecule therapies for severe and life-threatening diseases. Listen in as Warren walks us through their approach of partnering with Universities to find scientific discoveries that could become the next generation of therapies, and Reata’s recent success developing a groundbreaking new treatment for Friedreich’s Ataxia (FA), thanks to close collaboration with patient organizations and novel use of natural history data to accelerate their clinical development. by The Genetics Podcast

47 min listen

EP104: Assessing the clinical utility of Polygenic Risk Scores in cancer screening with Professor Clare Turnbull: Join Patrick Short and Professor Clare Turnbull, Professor in Translational Cancer Genetics at the Institute of Cancer Research, as they discuss polygenic risk scores and their application in healthcare. Delve into the complexities of predicting disease, the challenges of screening programs, and the potential impact of integrating genomics into healthcare systems. Discover the limitations and potential of polygenic risk scores and gain valuable insights into the future of personalized medicine. by The Genetics Podcast

44 min listen

EP103: Gene Writing with Tessera Therapeutics CEO, Dr. Mike Severino: In this episode, Patrick is joined by Dr. Mike Severino, CEO of Tessera Therapeutics and CEO-Partner of Flagship Pioneering. Join us as Mike walks us through Tessera’s approach to treating genetic diseases by rewriting bases, exons, or even whole genes with a novel approach called Gene Writing. by The Genetics Podcast

44 min listen

EP102: Dr. Marco Schmidt, founder and Chief Scientific Officer of BioTx.ai, on how to use artificial intelligence and machine learning in genomics research: In this episode, Patrick is joined by Dr. Marco Schmidt, founder and Chief Scientific Officer of Biotx.ai. His company uses artificial intelligence and machine learning to expedite the selection of drug candidates using genomic data. Tune in to learn how they utilize algorithms for ‘causal inference’ to establish cause and effect between genetic variants and phenotypes, s and what that means for the field of drug development and clinical trials. by The Genetics Podcast

38 min listen

EP101: Fostering international progress towards personalised medicine with Dr. Bettina Lundgren, CEO of the Danish National Genome Center: Join Patrick in welcoming Dr. Bettina Lundgren, CEO of the Danish National Genome Center. Bettina is spearheading the development of personalised medicine in Denmark with a focus on integrating genome sequencing directly into the healthcare system. by The Genetics Podcast

28 min listen

EP100: Evolving technologies and the frontiers of genomics research with Dr Matthew Hurles, Director of the Wellcome Sanger Institute: In this milestone episode, we welcome Dr Matthew Hurles, a geneticist and pioneer in the field of human genomics. by The Genetics Podcast

44 min listen

EP99: Exploring the frontiers of cancer research with Dr. Harold E Varmus by The Genetics Podcast

45 min listen

EP 98: Cancer, ageing, and somatic mutation variation across mammals with Alex Cagan (Wellcome Sanger Institute) by The Genetics Podcast

39 min listen

EP 97: Proteomics deep dive with Cindy Lawley (Olink): In this episode, Patrick is joined by Cindy Lawley, Senior Director of Population Health at Olink Proteomics and co-host of the Proteomics in Proximity podcast. Cindy has worked with major population genomics programs, including the UK Biobank, to bring together proteomics, genomics, and deep phenotyping using the Olink platform. by The Genetics Podcast

60 min listen

EP 96: CEO of Montai Health, Margo Georgiadis, talks the intersection of nature and AI: This week, we’re welcoming the CEO of Montai Health, Margo Georgiadis, to the podcast to discuss their AI platform that uses literature and wet lab experiments to analyse “the most privileged chemistry on Earth” to find new treatments for chronic diseases. by The Genetics Podcast

51 min listen

EP 95: Resharing Eric Topol on how Machine Learning & AI can Contribute to the Future of Healthcare: In 2019, we had the pleasure of speaking with Dr Eric Topol, author of ‘The Patient Will See You Now’ and ‘Deep Medicine.’ Now, we're re-sharing the interview when the conversation is more relevant than ever. by The Genetics Podcast

39 min listen

EP 94: Alnylam’s Dr Paul Nioi on how genetics is used in drug target discovery: In this jam-packed 45-minute episode, we’re joined by Dr Paul Nioi, Vice President of Discovery and Translational Research at Alnylam Pharmaceuticals and Chair of the Founders Board for Our Future Health. by The Genetics Podcast

45 min listen

EP 93: International Perspectives on Access to Genetic Testing in ALS: In this webinar, Paul Wicks leads the discussion with Professor Ammar Al-Chalabi, Dr Patrick Short and Kristina Salmon on international perspectives on genetic testing for ALS. by The Genetics Podcast

41 min listen

EP 92: Four Predictions for 2023: From changing drug pricing legislation to AI breakthroughs, in the first episode of The Genetics Podcast for 2023, Patrick makes four predictions for the biggest stories of 2023. by The Genetics Podcast

14 min listen

EP 91: 2022 Genetics Round-up with Dr Veera Rajagopal: In the final episode of The Genetics Podcast for 2022, we’re joined by Dr Veera Rajagopal, who is known as the ‘GWAS storyteller’ on Twitter for his prolific threads breaking down the latest findings in genetics. by The Genetics Podcast

90 min listen

EP 90: Patient-centric drug development in ALS with Ronald van der Geest, Chief Development Officer of Treeway: This week Patrick is joined by Treeway Chief Development Officer Ronald van der Geest. Join them as they discuss Treeway's roots, the four major disciplines required for successful development of novel treatments, and the landscape of ALS. by The Genetics Podcast

35 min listen

EP 89: Baroness Nicola Blackwood on the UK's leading role in delivering 'genomic healthcare for everyone': This week Patrick is joined by Baroness Nicola Blackwood of North Oxford. Nicola is chair of Genomics England, a diverse community of genomic clinicians and researchers providing a world-class service platform for genetic testing to patients. by The Genetics Podcast

33 min listen

EP 87: Representation Matters: Why equitable access and community engagement are critical in genetic research: In the age of precision medicine, ensuring equitable access and representation from participants of all communities is of vital importance when conducting genetic research. by The Genetics Podcast

50 min listen

EP 86: Curating and collaborating genomic datasets to guide the future of diagnostic and clinical research with Heidi Rehm PhD, Chief Genomics Officer at Massachusetts General Hospital: Patrick speaks to Heidi Rehm who is at the top of the field of genome interpretation and medical genetics. by The Genetics Podcast

37 min listen

EP 85: Distinguished Research Professor Dr Jessica Kissinger discusses her work in evolutionary biology specific to pathogenic parasites: Dr Jessica Kissinger has been heavily involved in parasite genomics since the late 1990s, running some of the largest collaborative databases in the world and helping to pioneer early searchable datasets in the field of parasite genomics. by The Genetics Podcast

34 min listen

EP 84: Mark Kotter, CEO, and Founder of bit.bio, on creating every cell type and kickstarting a cell therapy revolution: Doctors have been transplanting organs for decades, but can we transplant reprogrammed stem cells to rejuvenate the human body? by The Genetics Podcast

35 min listen

EP 83: Daphne Koller, Founder & CEO of Insitro - Integrating machine learning and biology at scale to reimagine drug discovery: This week’s guest, Daphne Koller, is the Founder and CEO of Insitro - a company shifting the paradigm of new drug discovery using predictive models. by The Genetics Podcast

45 min listen

EP 82: Lessons from the world's largest genomic datasets with Daniel MacArthur, Director of the Centre for Population Genomics.: This week’s guest, Daniel MacArthur, is the Director of the Centre for Population Genomics at the Garvan Institute of Medical Research and Murdoch Children's Research Institute. by The Genetics Podcast

46 min listen

EP 81: Cracking the druggable genome with Dietrich Stephan, Founder and CEO of NeuBase Therapeutics: This week Patrick is joined by Dietrich Stephan, Founder and CEO of NeuBase Therapeutics. by The Genetics Podcast

43 min listen

EP 80: Rare disease genomics and the 'near-coding' genome with Nicky Whiffin, Group Leader at the Wellcome Centre for Human Genetics: From decoding the genetics of rare disease using computational methods, to understanding the non-coding and 'near-coding' genome, this week Patrick is joined by Nicky Whiffin, Group Leader at the Wellcome Centre for Human Genetics and Sir Henry Dale Fellow at the University of Oxford. by The Genetics Podcast

25 min listen

EP 79: The Unknown Causes of Kidney Disease Project with Michael Spigler, Vice President of Patient Support and Education at American Kidney Fund: In this week’s episode Patrick is joined by Michael Spigler, Vice President of Patient Support and Education at American Kidney Fund. by The Genetics Podcast

30 min listen

EP 78: From datasets to front-line healthcare; polygenic risk scores and genomic prediction with Prof Sir Peter Donnelly, CEO of Genomics PLC: This week Patrick is joined by Sir Peter Donnelly, CEO of Genomics PLC and Professor of Statistical Science at the University of Oxford. by The Genetics Podcast

46 min listen

EP 76: The UK Biobank Whole Genome Sequencing Project: building the future of genomics research with Dr Mark Effingham, Dr Kári Stefánsson and Professor Marylyn Ritchie: This week Patrick is joined by three pioneering guests united by one ground-breaking project: the UK BioBank’s Whole Genome Sequencing Project. by The Genetics Podcast

41 min listen

EP 75: Participant engagement in genomics research, with Nathalie Kingston, Director of the NIHR BioResource: This week’s guest is Nathalie Kingston, Director of the NIHR BioResource. by The Genetics Podcast

41 min listen

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EP 77: The journey to novel gene therapies for hearing loss and balance disorders with Laurence Reid, CEO at Decibel Therapeutics

EP 77: The journey to novel gene therapies for hearing loss and balance disorders with Laurence Reid, CEO at Decibel Therapeutics

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