Natural resource managers worldwide face a growing challenge: Global change increasingly propels ecosystems on strong trajectories toward irreversible ecological transformations. As once-familiar historical ecological conditions fade, managers need new approaches to guide decision-making. In a special section in BioScience, three dozen authors, led by National Park Service (NPS) ecologist Gregor Schuurman and US Geological Survey social scientist Amanda Cravens, describe the Resist–Accept–Direct (RAD) framework, designed for and by managers. The collection of articles is focused on understanding and responding to the challenges of stewarding ecological systems in a time of intensifying global change.            According to the section authors, the RAD framework gives managers three general pathways for responding to change: They can take actions to resist the change, they can accept it, or they can try to direct the change to produce desirable outcomes. The NPS has honed the RAD framework with an expanding circle of parks and adaptation partners over the past half-dozen years, with federal natural resource management agencies collaborating to develop guidance for stewarding transforming ecosystems. The special section can be found in the January issue of BioScience. For this episode of BioScience Talks, we are joined by Dr. Schuurman to discuss the RAD framework and the special section that describes it. More about the RAD framework can be found on web pages maintained by the NPS and USGS.