A variety of papers, including CRASH-2, suggest that TXA can decrease mortality if given early for patients at risk of significant hemorrhage but exclude patients with TBI. CRASH-3 was a large, multi-national placebo-controlled randomized trial comparing TXA, 1 gm over 10 minutes, followed by a subsequent 1 gm infusion over the next 8 hours. So… what do we think of the paper’s results, and do we believe TXA should be given in TBI patients? The EMS Lighthouse Project Podcast is the newest show on the FlightBridgeED clinical podcast network! Your feedback has been fantastic, and we appreciate the support! If you haven’t, please leave feedback and give is a rating on your favorite podcast app!