Are Pain Meds for Dogs Safe?   By Jennifer Coates, DVM   Knowing that a dog is in pain is upsetting. So it's an understandable reaction to want to do something — anything — to provide the dog pain relief as soon as possible.   However, as tempting as it may be to reach for an over-the-counter pain medications such as ibuprofen, aspirin, or acetaminophen and give it to the family dog, you must avoid them at all costs. Over-the-counter pain meds (OTC medications) and human medications can be very dangerous, even fatal, when used improperly in dogs. Dogs should not be given Advil, aspirin, Tylenol, or any other pain reliever made for human consumption.   NSAIDs and Asprin for Dogs – Are They Dangerous?   Some of the most common over-the-counter pain relievers fall into the category of nonsteroidal anti-inflammatories (NSAIDs). Common examples include aspirin, baby aspirin ibuprofen, and naproxen. They all work by inhibiting an enzyme called cyclooxygenase that is responsible for the production of prostaglandins that promote inflammation, fever, and pain.   But prostaglandins also play many other roles in the body, including maintaining adequate blood flow to the kidneys, the production of a layer of mucus that protects the inner lining of the gastrointestinal tract from stomach acid, and normal blood clotting. When these functions are reduced, dogs can develop vomiting and diarrhea (often bloody), intestinal problems, loss of appetite, bleeding disorders, kidney or liver dysfunction or failure. They may even die without appropriate treatment. It is not safe to give your dog any amount of aspirin, ibuprofen (Advil), naproxen, or other anti-inflammatory meant for humans.   Problems can arise with NSAID use in dogs for several reasons: Sometimes an owner will give (or a dog will get into) an inappropriately high dose of one or more of these drugs. Certain dogs are especially sensitive to human NSAID brands and can develop dangerous side effects even when a correct dose is given. The concurrent use of other medications (e.g., corticosteroids) and/or the presence of certain health conditions (e.g., gastrointestinal, liver, or kidney disease) can make the use of NSAIDs for dogs more risky than normal.   (NOTE: Cats are especially sensitive to the adverse effects of NSAIDs, but because more dogs are exposed to these medications, a greater number of NSAID toxicity cases are reported in dogs in comparison to cats.)   What About Tylenol for Dogs?   Acetaminophen (Tylenol) presents a slightly different story. Acetaminophen is not an NSAID. No one is exactly sure how it works to reduce pain and fever (it has no effect on inflammation), but when dogs ingest toxic amounts of acetaminophen, it destroys their liver cells, damages the kidneys, and converts hemoglobin, the oxygen-carrying molecule in blood, to methemoglobin resulting poor oxygen delivery throughout the body and tissue damage.   (NOTE: Cats are so sensitive to the adverse effects of acetaminophen that just one, regular strength tablet can result in death.)   What Can I Give My Dog For Pain Relief?   For all of the above reasons, you should not give NSAIDs, like aspirin and ibuprofen, or other pain relievers, such as Tylenol, to dogs or other pets without the supervision of a veterinarian. Drug companies have designed specific canine pain medication that are safer and more effective than those that are designed for people. Examples of these modern pain killers include carprofen, deracoxib, etodolac, and meloxicam.   With knowledge of the specifics of a dog’s health history, your vet can make a proper diagnosis to determine which medication and dose is most appropriate for your dog and design a plan for monitoring that will make treatment as safe as possible.   Other Pain Relief Measures   Appropriate medicine is not the only way to provide dog pain relief, however. Chronic inflammatory conditions such as general arthritis often respond well to dietary modification. For example, do