Myelodysplastic neoplasms, or myelodysplastic syndromes, are diagnosed in approximately 4 of 100 000 people each year in the US and are associated with a 5-year survival rate of approximately 37%. In this JAMA podcast and author interview, JAMA Deputy Editor Mary M. McDermott, MD, discusses the diagnosis and treatment of myelodysplastic syndromes with Mikkael A. Sekeres, MD, MS, chief of hematology and professor of medicine of the Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine. Related Content: Diagnosis and Treatment of Myelodysplastic Syndromes