In this episode, we cover one of the most influential books in the history of surgery, the 'De Humane Corporis Fabrica', and its author, Andreas Vesalius. In doing so, we'll also explore the outsized influence of the ancient Roman physician Galen on anatomical knowledge, and the challenges Vesalius faced in shaking the yoke of tradition through empirical evidence. One of the giants of Renaissance medicine, Vesalius laid the groundwork for the modern field of anatomy, and in so doing, modern surgery as well.