Bryan King & Matthew State Part 1: Developing Autism Spectrum Disorder Therapeutics: Treatment Targets and Tools from 30,000 Feet

Prescott Woodruff & Joseph Arron Part 1: Molecular Phenotyping of Asthma: Asthma is a heterogeneous disease with varying degrees of airway inflammation and variable response to treatment with inhaled corticosteroids. Woodruff and Arron describe experiments to develop a biomarker to detect asthma subtypes and determine which ... by iBiology Videos

33 min listen

Prescott Woodruff & Joseph Arron Part 2: Asthma heterogeneity: biomarkers and drug development: Asthma is a heterogeneous disease with varying degrees of airway inflammation and variable response to treatment with inhaled corticosteroids. Woodruff and Arron describe experiments to develop a biomarker to detect asthma subtypes and determine which ... by iBiology Videos

43 min listen

Esteban Burchard Part 1: Racial Bias in Science and Medicine: Who’s Included?: There is ample evidence that race can be a major factor in health outcomes. But racial and ethnic minorities are underrepresented in clinical and biomedical research. In this series, Dr. Esteban Burchard talks about the consequences of this underrepres... by iBiology Videos

4 min listen

Tom Gadek Part 3: Discovery and development of Lifitegrast: Clinical Study: In his third lecture, Gadek outlines Lifitegrast clinical trials, from Phase 1 to Phase 3, and presents evidence of Lifitegrast’s safety profile in normal individuals as well as the efficacy of the drug in treating dry eye syndrome. by iBiology Videos

39 min listen

Deepak Srivastava Part 1: A Change of Heart: Embryonic Heart Development: During embryogenesis, the heart needs to form a specific three-dimensional shape or a child will be born with a defective heart. Srivastava and his colleagues hope that by better understanding the molecular pathways involved in normal heart development... by iBiology Videos

31 min listen

Carolyn Calfee & Michael Matthay Part 1: Acute Respiratory Distress Syndrome: An Overview: Acute respiratory distress syndrome is a life threatening condition with few effective treatment options. Preliminary studies using mesenchymal stem cells, or stromal cells, to treat ARDS have shown promise with decreased levels of bacteria in the lung... by iBiology Videos

11 min listen

Esteban Burchard Part 2: The Impact of Race and Genetic Ancestry on Medicine: Which Box Do I Check?: There is ample evidence that race can be a major factor in health outcomes. But racial and ethnic minorities are underrepresented in clinical and biomedical research. In this series, Dr. Esteban Burchard talks about the consequences of this underrepres... by iBiology Videos

4 min listen

Ted Yednock Part 2: Response to the Emergence of Progressive Multifocal Leukoencephalopathy: Just a few months after Tysabri was approved for MS treatment, two patients developed progressive multifocal leukoencephalopathy (PML), a fatal or seriously debilitating disease. In his second talk, Yednock describes the response of medical and regula... by iBiology Videos

29 min listen

Rebecca Calisi Rodríguez: Charting an Original Path: Rebecca Calisi Rodríguez’s research on pigeons, like her life, is one of charting an original path. Her experiences as a Mexican-Italian-American woman, professor, artist and mother have provided her with fascinating and unusual perspectives to study t... by iBiology Videos

10 min listen

Deepak Srivastava Part 2: A Change of Heart: In vivo Cellular Reprogramming: About half of the cells in an adult heart are cardiac myocytes, or muscle cells, and about half are cardiac fibroblasts or support cells. Following a heart attack, muscle is lost and fibroblasts form scar tissue. In his second talk, by iBiology Videos

19 min listen

Christine Stadelmann & Mikael Simons Part 1: Myelination, Remyelination and Multiple Sclerosis: Multiple sclerosis (MS) is a debilitating autoimmune disease in which immune cells infiltrate the central nervous system and attack the myelin sheath surrounding axons. Dr. Simons explains that myelin is necessary for signal conduction by nerve cells ... by iBiology Videos

18 min listen

Louis Ptáček & Ying-Hui Fu Part 1: Connections between Clock and other Phenotypes: By studying families with sleep/wake disorders, Fu and Ptáček have shown that mutations that cause changes in the phosphorylation or acylation of the PER2 protein are responsible for regulating circadian rhythms. by iBiology Videos

34 min listen

Manu Prakash: Scientific Curiosity: Finding Sublime in the Mundane: Manu Prakash always yearned to know the why and the how of things. As a boy in India, he spent endless hours playing outside with animals and making flammable artifacts in an abandoned lab in the basement of his home. by iBiology Videos

9 min listen

Esteban Burchard Part 3: Inclusion of Minorities in Science and Medicine: An Inclusive Future: There is ample evidence that race can be a major factor in health outcomes. But racial and ethnic minorities are underrepresented in clinical and biomedical research. In this series, Dr. Esteban Burchard talks about the consequences of this underrepres... by iBiology Videos

7 min listen

Ted Yednock Part 1: Immune Cell Migration to the CNS: Yednock relates the discovery and development, over 15 years, of the drug Tysabri, an alpha4 integrin antibody, as a treatment for multiple sclerosis. In the first of his two talks, Ted Yednock begins with an overview of multiple sclerosis. by iBiology Videos

35 min listen

Tom Gadek Part 1: The SARcode Story: How to build a biotech company: Using the company he co-founded, SARcode, as an example, Dr. Tom Gadek tells us how one converts a novel idea into a successful company. He walks us through the discovery of Lifitegrast to treat dry eye syndrome, the founding of SARcode in 2006, by iBiology Videos

50 min listen

Ricardo Dolmetsch: Neurodevelopmental disease: Drug Discovery in Neuroscience: Drug discovery for diseases of the nervous system is difficult. Although mouse models are helpful to study many human diseases, they have serious limitations for understanding neurological and psychiatric disease. by iBiology Videos

45 min listen

Carolyn Calfee & Michael Matthay Part 2: Mesenchymal Stem Cell Therapy for ARDS: In Part 2, Dr. Matthay provides the rationale behind treating ARDS patients with MSC. Initial studies in a mouse model of ARDS, showed that treatment with MSCs increased levels of anti-inflammatory cytokines and antimicrobial peptides in the lung, by iBiology Videos

35 min listen

Nico Stuurman: Introduction to Image Acquisition for Quantitative Analysis: How do we visualize biological samples? In this talk, Dr. Nico Stuurman provides an overview of the different tools, equipment, and software available to acquire an image of a biological sample using a light microscope, by iBiology Videos

30 min listen

Wallace Marshall & Jacque Duncan Part 1: Ciliopathies and Retinal Degeneration: Cilia and flagella are complex, but highly conserved, structures found on most cells of the human body. Mutations in proteins localized to cilia can cause a collection of human diseases including renal failure and retinal degeneration. Dr. by iBiology Videos

23 min listen

Kevin Eliceiri: ImageJ: Since 1987, different versions of ImageJ have been used by scientists to analyze biological images. In this talk, Dr. Kevin Eliceiri provides an overview of ImageJ, explains how ImageJ has evolved through time, by iBiology Videos

9 min listen

Louis Ptáček & Ying-Hui Fu Part 2: Understanding our Sleep Behaviors: By studying families with sleep/wake disorders, Fu and Ptáček have shown that mutations that cause changes in the phosphorylation or acylation of the PER2 protein are responsible for regulating circadian rhythms. In Part 2 of the talk, Dr. by iBiology Videos

24 min listen

The Tools: Active Learning Methods: How can instructors get started with active learning? What simple and effective active learning methods can easily be implemented in a course? Hear from instructors about their experience and see classroom demonstrations using think-pair-share and clic... by iBiology Videos

7 min listen

Christine Stadelmann & Mikael Simons Part 2: Neuropathology of Multiple Sclerosis: MS begins as a disease of intermittent episodes with recovery in between. With time, however, MS changes to a progressive disease with increasing disability. In her talk, Dr. Stadelmann explains that studies of MS brain lesions have identified specifi... by iBiology Videos

25 min listen

Jason Swedlow: Metadata in BioImaging: Management, Organization, and Sharing BioImaging Data: In order to understand an image of a biological sample and what it represents, one needs to understand its metadata. Metadata is the information behind the image that shows the experimental procedure, image acquisition settings, by iBiology Videos

23 min listen

Jennifer Doudna: Genome Engineering with CRISPR-Cas9: Birth of a Breakthrough Technology: Jennifer Doudna tells the story of how studying the way bacteria fight viral infection turned into a genomic engineering technology that has transformed molecular biology research. In 2013, Doudna and her colleagues developed the CRISPR-Cas9 gene expre... by iBiology Videos

17 min listen

Bryan King & Matthew State Part 1: Developing Autism Spectrum Disorder Therapeutics: Treatment Targets and Tools from 30,000 Feet: In the first lecture, Dr. Bryan King introduces the autism spectrum disorder (ASD) and defines the clinical criteria that characterizes ASD. Although there is no universal drug that is used to treat ASD, there are multiple medications used in the setti... by iBiology Videos

35 min listen

Tejal Desai & Robert Bhisitkul: Advancing the Treatment of Retinal Diseases: Robert Bhisitkul and Tejal Desai describe how treatment for retinal diseases leading to vision loss, such as age related macular degeneration, may be much improved by efforts to develop implantable devices for drug delivery. by iBiology Videos

35 min listen

Bryan King & Matthew State Part 2: From Genes to Pathology in Autism Spectrum Disorders: In the second lecture, Dr. Matthew State overviews the hunt for genes associated with autism and explains how studying de-novo rare mutations in the germline has advanced the understanding of the genetics of autism spectrum disorder (ASD). by iBiology Videos

35 min listen

Tom Gadek Part 2: Discovery and development of Lifitegrast to treat dry eye syndrome: Pharmacology: In his second lecture, Gadek reviews the molecular mechanism of dry eye syndrome, focusing on the role of inflammation and T-cells in this disorder. By analyzing clinical trial data from other drugs developed to treat dry eye, by iBiology Videos

33 min listen

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Bryan King & Matthew State Part 1: Developing Autism Spectrum Disorder Therapeutics: Treatment Targets and Tools from 30,000 Feet

Bryan King & Matthew State Part 1: Developing Autism Spectrum Disorder Therapeutics: Treatment Targets and Tools from 30,000 Feet

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