Malaria continues to be a major “killer’ in the developing world affecting the most vulnerable populations with more than 500,000 deaths per year. Emergence of resistance to antimalarial drugs is major public health issue. In this episode, we will discuss the latest information on this rapidly evolving field with one of the foremost experts in the field. • Review the main factors leading to malaria resistance • Discuss the main genetic mechanism of resistance to antimalarials. • Elaborate on future approaches for the prevention of resistance in Plasmodium spp. Guest: Professor Sir Nicholas White. Professor of Tropical Medicine at Oxford University and Mahidol University in Thailand. Visit https://asm.org/eic for links and https://journals.asm.org/journal/aac to read the AAC Journal