Migraines are PAINFUL! And neuroscience speaking - super cool and complicated.  It involves your blood vessels constricting and dilating and your brain going haywire and spreading a wave of neuron depression across your entire cortex. Sound interesting? Come and take a listen to learn a little bit more about what happens in your brain!Please rate, review, and subscribe and if you have any questions, comments, concerns, queries, or complaints, please email me at neuroscienceamateurhour@gmail.com or DM me at NeuroscienceAmateurHour on Instagram.Citations below:Headache disorders. www.who.int. https://www.who.int/news-room/fact-sheets/detail/headache-disorders#:~:text=Half%20to%20three%20quarters%20ofMigraine Headaches: Symptoms, Causes, Treatment & Prevention. Cleveland Clinic. Published March 3, 2021. https://my.clevelandclinic.org/health/diseases/5005-migraine-headachesRuthirago D, Julayanont P, Kim J. Translational Correlation. Conn’s Translational Neuroscience. Published online 2017:159-165. doi:10.1016/b978-0-12-802381-5.00013-0Mason BN, Russo AF. Vascular Contributions to Migraine: Time to Revisit? Frontiers in Cellular Neuroscience. 2018;12. doi:10.3389/fncel.2018.00233Wikipedia Contributors. Aristides Leão. Wikipedia. Published January 9, 2022. Accessed March 22, 2022. https://en.wikipedia.org/wiki/Aristides_Le%C3%A3oLauritzen M. Pathophysiology of the migraine aura. Brain. 1994;117(1):199-210. doi:10.1093/brain/117.1.199Schain AJ, Melo-Carrillo A, Stratton J, Strassman AM, Burstein R. CSD-Induced Arterial Dilatation and Plasma Protein Extravasation Are Unaffected by Fremanezumab: Implications for CGRP’s Role in Migraine with Aura. The Journal of Neuroscience. 2019;39(30):6001-6011. doi:10.1523/jneurosci.0232-19.2019Charles A, Brennan K. Cortical Spreading Depression—New Insights and Persistent Questions. Cephalalgia. 2009;29(10):1115-1124. doi:10.1111/j.1468-2982.2009.01983.xPietrobon D, Striessnig J. Neurobiology of migraine. Nature Reviews Neuroscience. 2003;4(5):386-398. doi:10.1038/nrn1102Eisenstein M. Closing the gender gap in migraine research. Nature. 2020;586(7829):S16-S17. doi:10.1038/d41586-020-02867-4Sutherland HG, Albury CL, Griffiths LR. Advances in genetics of migraine. The Journal of Headache and Pain. 2019;20(1). doi:10.1186/s10194-019-1017-9Support the show