Marianne Boesky established her eponymous gallery in New York in 1996. Since its inception, the gallery has represented and supported the work of emerging and established contemporary artists of all media and genres. In its first decade, the gallery was instrumental in launching the careers of major artists including Barnaby Furnas, Takashi Murakami, Yoshitomo Nara, Sarah Sze, and Lisa Yuskavage. The gallery currently represents many significant international artists, including Ghada Amer, Jennifer Bartlett, Sanford Biggers, Pier Paolo Calzolari, Donald Moffett, and Frank Stella. Boesky relocated her flagship gallery from SoHo to Chelsea in 2001, and in 2016, the gallery expanded its flagship location to include its adjacent space on West 24th Street. In 2017, Boesky opened a location in Aspen, Colorado; she has organized temporary exhibition spaces in Europe and in cities across the United States.

She and Zuckerman discuss family legacy, audacity, learning from artists, bank loans, consiglieres, vision,  looking at everything, being a mom in the artworld, mentoring, and not rushing!