TWiN 15: Microbiome and neurodevelopment with Helen Vuong

TWiN 50: Neurological sequelae after COVID-19: TWiN reviews experiments which show that SARS-CoV-2 triggers the up-regulation of synaptic components and perturbs local electrical field potential in cerebral organoids, organotypic culture of human brain explants and post-mortem brain samples from... by This Week in Neuroscience

64 min listen

TWiN 49: Mirror, mirror on the wall, who's the fairest mouse of all?: TWiN welcomes mice to the elite club of ‘self-aware’ animals, with a study demonstrating a mirror-induced self-directed behavior in mice resembling visual self-recognition. Hosts: , , and Vivianne Morrison Subscribe (free):... by This Week in Neuroscience

91 min listen

TWiN 48: Traumatic brain injury and retroviruses: TWiN describes a study that reveals activation of endogenous retroviruses in oligodenroglia from patients with traumatic brain injury. Hosts: , , and Subscribe (free): , , Links for this episode Activation of... by This Week in Neuroscience

51 min listen

TWiN 47: Walking after spinal cord injury: TWiN explains an amazing study of a man who was paralyzed after a spinal cord injury and regained the ability to walk after implantation of a brain-spinal cord interface. Hosts: , , and Subscribe (free): , , Links for... by This Week in Neuroscience

55 min listen

TWiN 46: Neuronal activity promotes glioma progression: TWiN explains research showing that interaction between glioma cells and neurons in the brain shares mechanistic features with synaptic plasticity that contributes to memory and learning in the healthy brain. Hosts: , , and ... by This Week in Neuroscience

51 min listen

TWiN 45: Acupuncture modulates the immune system: TWiN discusses research showing that sciatic nerve activation with electroacupuncture at the sciatic nerve controls systemic inflammation and rescues mice from polymicrobial peritonitis, by inducing vagal activation of aromatic L-amino acid... by This Week in Neuroscience

52 min listen

TWiN 44: ADHD and persistent pain: TWiN reviews a mouse model of ADHD to characterize hypersensitivity to pain, and that sensitization is further amplified in a pathological inflammatory state. Hosts: , , and Subscribe (free): , , Links for this episode ... by This Week in Neuroscience

61 min listen

TWiN 43: Pavlovian opioid tolerance: TWiN discusses a study of on the pathways that control opioid analgesic tolerance, a root cause of opioid overdose and misuse, which can develop through an associative learning. Hosts: , , and Subscribe (free): , , Links for... by This Week in Neuroscience

63 min listen

TWiN 42: Therapeutic effects of psychedelic drugs: TWiN explains how psychedelic drugs such as LSD, psilocybin, and MDMA, which are being explored for treating a wide range of neuropsychiatric diseases, reopen the social reward period for critical learning. Hosts: , , and Click arrow... by This Week in Neuroscience

57 min listen

TWiN 41: Alzheimer's and melanin-concentrating hormone: Vivianne explains how early in Alzheimer’s disease, the brain attempts to counteract the increased excitatory drive caused by amyloid deposition, and that melanin-concentrating hormone, produced during sleep, is involved in this protective response.... by This Week in Neuroscience

79 min listen

TWiN 40: Dopamine organizes behavior's syllables: Tim takes TWiN through two studies on the role of dopamine: that syllables are natural units of spontaneous behavior used by the brain to structure action, and that mesolimbic dopamine release conveys causal associations but not reward prediction... by This Week in Neuroscience

64 min listen

TWiN 39: Virus-like capsids trigger paraneoplastic disease: Junjie from Jason’s lab joins TWiN to discuss the observation that the cell gene PNMA2 encodes non-enveloped virus-like capsids that induce autoantibodies which underlie paraneoplastic syndrome. Hosts: , , , and Subscribe (free): , , ... by This Week in Neuroscience

53 min listen

TWiN 38: Bacterial immunity heals sensory neurons: TWiN explains the finding that immunity to commensal bacteria promotes sensory neuron regeneration via the cytokine interleukin-17A. Hosts: , , , and Vivianne Morrison Subscribe (free): , , Links for this episode Immunity to the... by This Week in Neuroscience

65 min listen

TWiN 37: Microglia at the crossroads: TWiN reviews the field of microgial research, which has advanced in recent decades but is constrained by nomenclature that is necessary but often implies specific functions. Hosts: , , , and Vivianne Morrison Subscribe... by This Week in Neuroscience

75 min listen

TWiN 36: Unbearable neurologists: TWiN answers listener questions about Alzheimer’s disease, glaucoma and the microbiota, Dravet’s Syndrome, schizophrenia, brain development, and chips implanted in the human brain. Hosts: , , , and Vivianne Morrison Subscribe... by This Week in Neuroscience

90 min listen

TWiN 35: Neuromodulation in treatment-resistant depression: Jason and Tim review the use of an implanted chronic deep brain sensing and stimulation device to carry out biomarker-driven closed-loop therapy that resulted in a rapid and sustained improvement in depression. Hosts: and Subscribe... by This Week in Neuroscience

69 min listen

TWiN 34: Microglia vital after spinal cord injury: TWiN explains how central nervous system resident macrophages known as microglia coordinate cellular interactions during spinal cord repair in mice. Hosts: , , , and Subscribe (free): , , , email Links for this episode Microglia... by This Week in Neuroscience

69 min listen

TWiN 33: Viruses leaving the brain: TWiN describes how neurotropic viruses leave the brain via meningeal lymphatic vessels located dorsally and basally beneath the skull. Hosts: , , , and Subscribe (free): , , , email Links for this episode Meningeal lymph vessels... by This Week in Neuroscience

58 min listen

TWiN 32: Relearning how to move after stroke: TWiN reviews how, in a mouse stroke model, recovery of movement is associated with the remaining cortex and the striatum coordinating their activity together. Hosts: Ori Lieberman, , and Vivianne Morrison Subscribe... by This Week in Neuroscience

60 min listen

TWiN 31: HIV-1 co-receptor shapes window for memory linking: TWiN explains the observation that in mice, the HIV-1 co-receptor CCR5 closes the temporal window for linking different memories. Hosts: , , , and Vivianne Morrison Subscribe (free): , , , email Links for this episode CCR5 and ... by This Week in Neuroscience

72 min listen

TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease: TWiN describes experiments demonstrating that gut injection of alpha-synuclein fibrils in mice converts endogenous alpha-synuclein to a pathologic form that spreads to the brain and leads to features of Parkinson’s disease. Hosts: , , , , and... by This Week in Neuroscience

70 min listen

TWiN 29: Astrocytes close the critical period: TWiN explains the finding that in the mouse visual cortex, astrocytes are key elements in the experience-dependent wiring of brain circuits. Hosts: , , , and Vivianne Morrison Subscribe (free): , , , email Become... by This Week in Neuroscience

62 min listen

TWiN 28: Oligodendrocyte performance enhancing exosomes: TWiN reveals how oligodendrocytes enhance axonal energy metabolism by transcellular delivery of a protein, SIRT2, that deacetylates mitochondrial proteins. Hosts: , , and Vivianne Morrison Click arrow to play Download (77 MB .mp3, 64 min)... by This Week in Neuroscience

74 min listen

TWiN 27: Eyes wired to the auditory cortex: TWiN discusses the finding that rewiring retinal projections to the auditory thalamus in ferrets leads to visually responsive cells that are typical of cells in the visual cortex. Hosts: Ori Lieberman, , , and Vivianne Morrison Subscribe... by This Week in Neuroscience

64 min listen

TWiN 26: Immunological memory in the brain: TWiN reviews evidence in mice that brain neurons encode and retrieve specific immune responses. Become a of TWiN! Links for this episode Memory of (Cell) Timestamps by . Thanks! Music is by Send your neuroscience... by This Week in Neuroscience

54 min listen

TWiN 25: Thanks for listening: TWiN answers listener questions on sex in neuroscience studies, rotating memories in the brain, odorant receptors in the brain, and neutrophils that promote neuron survival. Hosts: , , and Subscribe (free): , , , email Become... by This Week in Neuroscience

63 min listen

TWiN 24: Social transmission of maternal behavior with Ioana Carcea and Robert Froemke: Ioana and Robert join TWiN to discuss their work demonstrating that rodents acquire maternal behavior by social transmission from an experienced mother to a virgin female how to care for a litter via endogenous oxytocin. Hosts: and Guests: and ... by This Week in Neuroscience

73 min listen

TWiN 23: Peripheral nervous system with Bruce Carter: Bruce Carter joins TWiN to discuss the peripheral nervous system: the development of nerves that convey sensory information like touch from the tips of your toes to the brain, and Schwann cells, which are necessary for ensuring that... by This Week in Neuroscience

71 min listen

TWiN 22: It's never lupus: TWiN explains how anti-DNA antibodies present in lupus patients bind to GluN2A-containing NMDA receptors, act as positive allosteric modulators, and impair spatial memory. Hosts: , , Jason Shepherd, , and Vivianne Morrison Subscribe... by This Week in Neuroscience

68 min listen

TWiN 21: How do we know if a mouse is hallucinating?: TWiN explores a study of hallucination-like perception in mice which supports the idea that hallucinations arise as faulty perceptual inferences due to elevated dopamine in the striatum. Hosts: , , and Subscribe... by This Week in Neuroscience

88 min listen

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TWiN 15: Microbiome and neurodevelopment with Helen Vuong

TWiN 15: Microbiome and neurodevelopment with Helen Vuong

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