This is an ask me anything episode. The questions and timestamps are as follows:
01:13 Arjun Khemani “Why are problems inevitable?"
06:41 Jiten Terricola “There are differences between men and women. They have different propensities for doing things. What explains this when we’re all universal explainers each capable of doing what any other person can do?”
20:48 - David Hurn “With the right knowledge,can we change the laws of physics/reality? Or can we only get round them? #Optimism"
30:00 - Jeffcoast Bourbon “He’s written a bit on education; does he have any updated thoughts?”
44:58 DingbattusSapiens “Please ask him/her what fallibilism means :) Also, are we a self-domesticated species and why does Adam Sandler have a career.”
57:00  Kees Manshanden “How would you guard against knowledge production that's potentially catastrophic to humanity? For example, the knowledge to create 'easy nukes'; a weapon of mass destruction that can be made by anyone with a high school diploma.”
01:11:27 dean_of_no What is scientific thinking?
01:19:38 Alan Curtis “Why is there only one Monopolies Commission?”
01:32:00 Resty T “I know Deutsch describes his ideas as footnotes to Popper, but didn't he make improvements like "good explanations are hard-to-vary" or was that something Popper expressed too?”