On this episode, we are joined by Dr. Spencer Carter, MD and Dr. Kyle Fischer, PharmD, to discuss preserved ejection fraction heart failure. Dr. Carter is a cardiologist finishing his fellowship that is focused on heart failure and cardiac transplant.  Dr. Fischer is currently a PGY1 general clinical pharmacy resident. We begin by discussing some background information including pathophysiology and the clinical differences of HFpEF compared to HFrEF. We then review the medications often utilized in HFpEF. We finish with a deep dive into the new data surrounding sacubitril/valsartan in chronic heart failure (PARAGON HF) and the SGLT-2 inhibitors (EMPEROR-Preserved, DELIVER).  Follow Dr. Carter on Twitter: @spencercarter55 Follow Dr. Fischer on Twitter and Instagram: @Kfischer_10 and @kgfischerx Thanks for listening! If you want to support the podcast, check out our Patreon account. Subscribers will have access to all previous and new pharmacotherapy lectures as well as downloadable Power Point slides for each lecture. You can find our account at the website below:  www.patreon.com/corconsultrx If you have any questions for Cole or me, reach out to us on any of the following: Text - 415-943-6116 Mike - mcorvino@corconsultrx.com Cole - cswanson@corconsultrx.com Instagram and other social media platforms - @corconsultrx This podcast reviews current evidence-based medicine and pharmacy treatment options. This podcast is intended to be used for educational purposes only and is intended for healthcare professionals and students. This podcast is not for patients and not intended as advice or treatment.