COVID-19 Treatment Guideline co-authors Rajesh Gandhi, MD, FIDSA of Harvard University and Adarsh Bhimraj, MD, FIDSA of the Cleveland Clinic give an update on COVID-19 therapeutics and discuss two recently published papers in Clinical Infectious Diseases. Lessons learned from COVID-19 therapies: Critical perspectives from the IDSA COVID-19 treatment guideline panel: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab882/6398589 Therapeutic Emergency Use Authorizations (EUAs) During Pandemics: Double-Edged Swords: https://academic.oup.com/cid/advance-article/doi/10.1093/cid/ciab880/6398590